SCUBE3 identified as possible therapeutic treatment for androgenetic alopecia

[RagnarLothbrok]

Uhm, been checking a bit more about Plikus, he's definetely a chad researcher, he's been experimenting with finding hair mollecules for over 10 years now and has so many interesting research about wounding, stem cells, sonic hedgedog signaling and more

His publication research is pretty extense: https://plikuslab.bio.uci.edu/publications/

So if his company (Amplifica) is interested in the compound it must be because they truly believe it could work for hairloss. Now im curious about the compound too

 

[pegasus2]

Uhm, been checking a bit more about Plikus, he's definetely a chad researcher, he's been experimenting with finding hair mollecules for over 10 years now and has so many interesting research about wounding, stem cells, sonic hedgedog signaling and more

His publication research is pretty extense: https://plikuslab.bio.uci.edu/publications/

So if his company (Amplifica) is interested in the compound it must be because they truly believe it could work for hairloss. Now im curious about the compound too

Yeah, he's one of the smartest in the field. The research is fairly preliminary, but it shows a lot of promise. They are probably well underway with the next step in the research, but it will be a while before we get another paper on this.

 

[Joxy]

Another happy mice?

 

[RagnarLothbrok]

Another happy mice?

Just to clarify: it grew real human transplanted hair (on mice)

 

[RagnarLothbrok]

kinda surprised me to see Kevin Mann so hyped about it when he is usually very skeptic about everything (including HMI-115)

 

[Fgsfds]

Doesn't sound safe

Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression - PubMed

<span><b><i>Background:</i></b> Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3) has been found to be associated with the development of several cancers. However, the biological role of SCUBE3 in breast cancer progression has not been reported. <b><i>Materials and...

pubmed.ncbi.nlm.nih.gov

Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis? - PubMed

Angiogenesis is an important process being involved in the pathogenesis of psoriasis and promises new potential parameter for diagnosis and screening of treatment. This study investigated the levels of signal peptide-CUB-EGF (epidermal growth factor-like protein) family domain-containing protein...

pubmed.ncbi.nlm.nih.gov

SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer - PubMed

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of...

pubmed.ncbi.nlm.nih.gov

Granted it is a downstream of SHH, so makes sense it would have a hand in the cancer-causing effects of over-expressed SHH

And not even just that: https://pubmed.ncbi.nlm.nih.gov/17442284/

 

[pegasus2]

Doesn't sound safe

Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression - PubMed

<span><b><i>Background:</i></b> Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3) has been found to be associated with the development of several cancers. However, the biological role of SCUBE3 in breast cancer progression has not been reported. <b><i>Materials and...

pubmed.ncbi.nlm.nih.gov

Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis? - PubMed

Angiogenesis is an important process being involved in the pathogenesis of psoriasis and promises new potential parameter for diagnosis and screening of treatment. This study investigated the levels of signal peptide-CUB-EGF (epidermal growth factor-like protein) family domain-containing protein...

pubmed.ncbi.nlm.nih.gov

SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer - PubMed

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of...

pubmed.ncbi.nlm.nih.gov

Granted it is a downstream of SHH, so makes sense it would have a hand in the cancer-causing effects of over-expressed SHH

And not even just that: https://pubmed.ncbi.nlm.nih.gov/17442284/

We don't go for safety, we go for results.

Edit: this is going to have tissue specific effects more so than most drugs. It will be a topical, not something like finasteride. I don't think it will be dangerous.

 

[RagnarLothbrok]

Doesn't sound safe

Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression - PubMed

<span><b><i>Background:</i></b> Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3) has been found to be associated with the development of several cancers. However, the biological role of SCUBE3 in breast cancer progression has not been reported. <b><i>Materials and...

pubmed.ncbi.nlm.nih.gov

Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis? - PubMed

Angiogenesis is an important process being involved in the pathogenesis of psoriasis and promises new potential parameter for diagnosis and screening of treatment. This study investigated the levels of signal peptide-CUB-EGF (epidermal growth factor-like protein) family domain-containing protein...

pubmed.ncbi.nlm.nih.gov

SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer - PubMed

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of...

pubmed.ncbi.nlm.nih.gov

Granted it is a downstream of SHH, so makes sense it would have a hand in the cancer-causing effects of over-expressed SHH

And not even just that: https://pubmed.ncbi.nlm.nih.gov/17442284/

Uhm, if im not mistaken they found the SCUBE protein implications to hair growth through analysis of hairy moles. Moles are known to have increased cell activity and more prone to melanoma (skin cancer) than normal skin. I wonder if any of this has any connection.

 

[Kagaho]

We don't go for safety, we go for results.

Edit: this is going to have tissue specific effects more so than most drugs. It will be a topical, not something like finasteride. I don't think it will be dangerous.

Way too early to tell... Hope youre right, we really need this one.

 

[RagnarLothbrok]

The literal premise of finding SCUBE supposedly comes from the fact that interacting with Shh is highly dangerous. We have to assume that researchers had this in mind the whole time otherwise it seems focusing on this downstream (instead of Shh directly) would be completely pointless. So yeah, im optimistic it will be possible to deliver safely imo

Its so funny, choose AIDS from Cyclosporine or Cancer from SCUBE, thats our new options lool

 

[JohnDoe5]

Doesn't sound safe

Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression - PubMed

<span><b><i>Background:</i></b> Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3) has been found to be associated with the development of several cancers. However, the biological role of SCUBE3 in breast cancer progression has not been reported. <b><i>Materials and...

pubmed.ncbi.nlm.nih.gov

Can signal peptide-CUB-EGF domain-containing protein (SCUBE) levels be a marker of angiogenesis in patients with psoriasis? - PubMed

Angiogenesis is an important process being involved in the pathogenesis of psoriasis and promises new potential parameter for diagnosis and screening of treatment. This study investigated the levels of signal peptide-CUB-EGF (epidermal growth factor-like protein) family domain-containing protein...

pubmed.ncbi.nlm.nih.gov

SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer - PubMed

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of...

pubmed.ncbi.nlm.nih.gov

Granted it is a downstream of SHH, so makes sense it would have a hand in the cancer-causing effects of over-expressed SHH

And not even just that: https://pubmed.ncbi.nlm.nih.gov/17442284/

But we all already have SCUBE3 in our bodies so if we topically increase SCUBE3 a dab in the scalp it's not like we would be adding something new and totally unpredictable to our bodies. Also, there are newer topical vehicles that can dramatically reduce how much active drug seeps deeper into the body when applied topically.

 

[zaman]

Triphenyl phosphate potentially increases SCUBE3

 

[Armando Jose]

We don't go for safety, we go for results.

^^^^??

 

[FilthyFrancis]

Uhm, if im not mistaken they found the SCUBE protein implications to hair growth through analysis of hairy moles.

 

[Roeysdomi]

As always when its cure level its either cancer or HRT

 

[RagnarLothbrok]

the biggest cope would be if it works but its not safe. Because its one of the only ever drugs that could cause real hair follicle neogenesis (grow hair where it doesn't exist)

hairy moles grow terminal hair where it never existed too

 

[Mr. Slap Head]

the biggest cope would be if it works but its not safe. Because its one of the only ever drugs that could cause real hair follicle neogenesis (grow hair where it doesn't exist)

hairy moles grow terminal hair where it never existed too
View attachment 182298

Mmm nice donor

 

[pegasus2]

I wonder if it's possible to get SCUBE3 early or do we need to wait for it to go through all of the studies?

I don't think we are getting a small molecule for it, I think we're going to have to inject the protein. It is possible to get it, but getting proteins shipped to you without an actual research institution is more difficult than small molecules. It's also going to need to be encapsulated in liposomes to prevent it from being catabolized, and then injected. It has potential to work really well, but I'm not going that far for it based on preliminary research. It's probably less effective than r-spondin injections.

 

[SlappingHead]

the biggest cope would be if it works but its not safe. Because its one of the only ever drugs that could cause real hair follicle neogenesis (grow hair where it doesn't exist)

hairy moles grow terminal hair where it never existed too
View attachment 182298

Nice one ! I want it the exact same one on my eyebrows

 

[LoWS]

Amplifica: Novel Therapeutics for Hair Regrowth.

A biopharmaceutical company focused on developing novel treatments to address androgenic alopecia (hair loss), estimated to affect over 50 million men and over 30 million women in the US.

amplificabio.com

There isn't much information on the website ( Atleast for now) but any info about Scube3 clinical trial will be here.