Science behind PRP and adipose injections

[waynakyo]

There are a lot of claims out there, but i want to see whether there is any science that could back this up. Let s discuss this in this thread. some interesting papers:

http://www.ncbi.nlm.nih.gov/pubmed/24883322

http://www.ncbi.nlm.nih.gov/pubmed/23279091


http://www.ncbi.nlm.nih.gov/pubmed/22455565


http://www.ncbi.nlm.nih.gov/pubmed/21883644

http://www.ncbi.nlm.nih.gov/pubmed/22784094

 

[JZA70]

Let the link war begin.

 

[Mach]

Go get injections. I'm going in 2-3 months. Wonder if a clinic would reduce cost if 10 of us went the same day. Does Greco do these injections?

 

[Python]

Rat studies and a tracts are now useless to me

 

[benjt]

@waynakyo: From the studies themselves, you can only try to deduce what exactly happens as they did no basic research but only empirically observed downstream effects of the treatment instead of its mode of action.

One hypothesis: Dermal sheath cup cell reservoirs are replenished from plasma, whichever component in the plasma (adult stem cells?) it is that is needed to replenish the DSC cell reservoirs. This hypothesis would be supported by the theory behind RepliCel's approach.

 

[waynakyo]

@Python: you did not click the links, several are on humans

@Benjt: you are right, but I do not expect any clear answers on the mechanisms, and I am not sure I would trust any. We still do not have a clear explanation of why minoxidil works so well (relatively speaking). What puzzles me is the fact that it has been offered for several years now and I am yet to see someone who comes on these forums and claims it works (someone credible that is). Maybe because most have done it together with a hair transplant so it is hard to tell... The results of the studies above are not bad at all.

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clinical trial recruiting (maybe in Taiwan):
https://clinicaltrials.gov/ct2/show/study/NCT02087319?term=alopecia&rank=21

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Shapiro in Vancouver planning a trial too:

https://clinicaltrials.gov/ct2/show/study/NCT02074943?term=alopecia&rank=70