S5 cream ,Minoxidil, hairstyle Routine

[Norwood One]

From our own Captian Hook

" Researchers concluded that plasma canrenone (the major metabolite of spironolactone) levels were undetectable even after applying spironolactone cream to 55% of the patients body area. This means that spironolactone undergoes extensive metabolism before reaching the bloodstream"

I don't think topical spironolactone can give you sides unless you directly introduce it into your bloodstream. Aka don't put spironolactone after dermarolling. Is it possible? I suppose, everyone's body reacts differently.

 

[abovedagame]

For sure.
I usually order 25g of pure spironolactone powder at a time.
To make a 5% solution I do the following:
PHASE A:
3g Spironolactone dissolved in small amount of ethanol + DMI
- If the spironolactone doesn't dissolve right away, I usually fill up a saucepan with water and place the pyrex beaker (containing the mixture) in the centre, and stir until it is dissolved entirely.
PHASE B:
Take the aqueous solution and mix with 2 fluid ounces of base cream (http://www.amazon.com/Premium-Cream...F8&qid=1453668291&sr=8-4&keywords=base+cream; or my favourite--> http://www.skinactives.com/Sea-Kelp-Ultramarine.html)

This is just for a simple spironolactone cream.

Keep in mind you could add anything to the phase 1 solution, (I.e., Minoxidil, etc)

Im thinking about adding some 17a-estradiol to my next batch as it acts as a local 5AR inhibitor.
In theory, a topical AA (spironolactone) will occupy the AR; while the 17-ae inhibits 5ar. This would mean absolutely no DHT would be able to attack the hair follicle.

Where do you source spironolactone powder from?

 

[wilson2]

From our own Captian Hook

" Researchers concluded that plasma canrenone (the major metabolite of spironolactone) levels were undetectable even after applying spironolactone cream to 55% of the patients body area. This means that spironolactone undergoes extensive metabolism before reaching the bloodstream"

I don't think topical spironolactone can give you sides unless you directly introduce it into your bloodstream. Aka don't put spironolactone after dermarolling. Is it possible? I suppose, everyone's body reacts differently.

Thanks for the input. Yeah I've heard about that study a few times. I don't know though, it's from like 1988. Spironolactone IS a male to female drug, I would just like some more research as to it's endocrine safety profile aside from a study done 38 years ago. I've also wondered since they applied the drug to the back...

"In general the rate of absorption of chemicals through skin follows the following scheme from fastest to slowest: Scrotal > Forehead > Armpit≥ Scalp > Back = Abdomen > Palm = under surface of the foot" -Absorption (skin) Wikipedia

Where as you can see the scalp is quicker at absorbing a substance compared to the Back (albeit not not as good as something like the forehead). Also admittedly I'm not sure on the correlation between rate of absorption and systematic potential (though I'd assume it's positive). I understand me asking if it could give side effects is a bit like asking how long a string is. It's just that I understand the pharmacokinetics of this drug at a pretty basic level and would love if someone with a little more background could offer their opinion.

 

[Norwood One]

wilson, if you have more info please do share. I've been using it pretty much everyday and would like to hear what you find regarding the pharmacokinetics of it.

 

[wilson2]

Yeah I doubt ill find too much more info on the pharmacokinetics of it due to my lack of bio-chemistry knowledge lol. However I did do more research and found a post that I believe was first posted by Doctor Lee (someone who profited off selling topical spironolactone ; however he cited more studies). The studies that demonstrate spironolactone's lack of systematic side effects are

"12. Yamamoto A, Ito M. Topical spironolactone reduces sebum secretion rates in young adults. J Dermatol, 1996 Apr,23:4,243-6

18. Corval P, Michaued A, Menard J, et al: Antiandrogenic effect of spironolactones: Mechanism of action.

Endocrinology 1975;97:52-8

19. Messina M, Manieri C, Musso MC, Pastorino R.: Oral and topical spironolactone therapies in skin androgenization. anminerva Med, 1990 Apr-Jun,32:2,49-55

20. Wendt A, Hasan SH, Heinz I, Tauber U: Systemic effects of local antiandrogen therapy. Arch Dermatol Res 273:171,1982 "
I can't actually track down any of these studies online, however I'm assuming their not fraudulent lol. Once I can actually read these studies I would feel pretty confident taking topical spironolactone. Obviously self diagnosed side effects isn't an empirical science, and all we can really go by is clinical studies. So maybe previous reports of sides online are either having nocebo affects or absorbing way too much or maybe just super unlucky.