Role Of Non Androgenic Factors In Hair Loss And Hair Regrowth | HairLossTalk Forums

Role Of Non Androgenic Factors In Hair Loss And Hair Regrowth

Discussion in 'Hair Loss and Alopecia Published Studies' started by deraj, Nov 2, 2017.

  1. deraj

    deraj Member

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    IdealForehead likes this.
  2. IdealForehead

    IdealForehead Senior Member My Regimen

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    Thanks. I have been thinking about topical antihistamines a lot lately, and I think this paragraph summarizes where I think they exert their mechanism of action pretty well:

    Skin keratinocytes respond to antigens or trigger inflammation in response to repeated, exposure to pollution, UV damage, reactive oxygen species [26], nitric oxide [27], prostaglandins and histamine [28] leading to progressive inflammation. As mentioned earlier, Kalkan, Seçkin et al. [11], proposed that the ROS forms covalent bond with endogenous proteins in the cells, changing their immune signature and making them behave as new antigens, becoming targets of immunity, inflammation and autoimmune reactions. All these processes, lead to accumulation and release of intracellular cytokines. IL-1alpha, IL-1beta, which are shown to inhibit hair elongation in hair follicle cultures in vitro [29,30]. The same effect is also supported by cytokines and chemokine, monocyte chemo attractant protein-1 (MCP-1), [31], which has been identified to be active in hair follicles and sebaceous glands in androgenetic alopecia. Surrounding fibroblasts too can respond to these pro inflammatory stimuli [32].
    Antihistamines like cetirizine should block a lot of those pathways.
     
  3. deraj

    deraj Member

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    No worries, it's an interesting read, something I feel all of us concerned with hair loss should be mindful of. I really feel that hairloss is multi faceted and this article could suggest a lot of daily changes that could really boost peoples progress with their regimens.

    I've recently begun topical cetirizine myself, only just over a week in but I'm pretty hopeful of good things!
     
  4. countjulian

    countjulian Experienced Member My Regimen

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    Think they might work orally?
     
  5. IdealForehead

    IdealForehead Senior Member My Regimen

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    No. Not sufficient quantity. You'd probably have to eat enough pills to put you in a coma. Likely needs topical application to saturate the scalp.
     

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