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One of the ingredients in Revita is Methylisothiazolinone.
Methylisothiazolinone or MIT is a powerful biocide and preservative
Some studies have shown MIT to be allergenic and cytotoxic, and this has led to some concern over its use. In early December, 2004, a news broadcast from WNYT in Albany, NY reported that methylisothiazolinone had been linked to nerve cell death in scientific studies. In 2002, there was an in vitro study of the neurotoxicity of MIT in the department of Neurobiology at the University of Pittsburgh.
The physiological effects of MIT (specifically in shampoos and cosmetics) reside in the reduced communication between two neurons. Synaptic transmission is impeded by MIT; the basic result is a mal-development of the nerve’s axons and dendrites: the axon sends an electrical impulse through a tube (myelin sheath) to the axonal terminals where the impulse is received by the next nerve’s dendrites. The chemical that empowers this impulse (synaptic transmission) is an enzyme called focal adhesion kinase; FAK is both responsible for the growth of axons and dendrites and the signaling of impulses. But FAK has to be pushed to perform its function, so phosphates cling to FAK’s amino acid chain (a process called tyrosine phosphorylation). But with any amino acid chain, if a sequence is changed or some part is impeded or damaged, the desired function changes or fails to operate. MIT’s feature of mortifying the parts of other chemicals leads in to this; MIT’s dissolving capabilities restrict and eat away the FAK enzyme, and as this enzyme is being partially destroyed, new axons and dendrites cannot be made, thus preventing full electrical impulse and the ability to receive impulse.
The first set of studies published in 2002 in The Journal of Neuroscience involved acute exposure to mature rat neurons. The studies reported that 10-minute exposure at a high concentration - roughly 100 times the dose used in their current study - was lethal to these cells.
Methylisothiazolinone or MIT is a powerful biocide and preservative
Some studies have shown MIT to be allergenic and cytotoxic, and this has led to some concern over its use. In early December, 2004, a news broadcast from WNYT in Albany, NY reported that methylisothiazolinone had been linked to nerve cell death in scientific studies. In 2002, there was an in vitro study of the neurotoxicity of MIT in the department of Neurobiology at the University of Pittsburgh.
The physiological effects of MIT (specifically in shampoos and cosmetics) reside in the reduced communication between two neurons. Synaptic transmission is impeded by MIT; the basic result is a mal-development of the nerve’s axons and dendrites: the axon sends an electrical impulse through a tube (myelin sheath) to the axonal terminals where the impulse is received by the next nerve’s dendrites. The chemical that empowers this impulse (synaptic transmission) is an enzyme called focal adhesion kinase; FAK is both responsible for the growth of axons and dendrites and the signaling of impulses. But FAK has to be pushed to perform its function, so phosphates cling to FAK’s amino acid chain (a process called tyrosine phosphorylation). But with any amino acid chain, if a sequence is changed or some part is impeded or damaged, the desired function changes or fails to operate. MIT’s feature of mortifying the parts of other chemicals leads in to this; MIT’s dissolving capabilities restrict and eat away the FAK enzyme, and as this enzyme is being partially destroyed, new axons and dendrites cannot be made, thus preventing full electrical impulse and the ability to receive impulse.
The first set of studies published in 2002 in The Journal of Neuroscience involved acute exposure to mature rat neurons. The studies reported that 10-minute exposure at a high concentration - roughly 100 times the dose used in their current study - was lethal to these cells.
