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Stop focusing on the damn Norwood scale and hairloss pattern already.. Chimps go bald as well. Everything starts in the powerhouse of the cells.
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i use mitoq+skq1 for 3 years already +deuterium depleted water ---->without any good hair regrowth and wrinkles stay where they were....
i'm a doctor, i take mitoq 10mg(2caps morning) for like 3 years already, EOD or when i remember, 80% of time after i take 2 pills 2-3hours later a receive headache and drowsiness...so 20mg will be not good for me....MitoQ is great, you need to take at least 20mg a day for results.
That study is pretty impressive:
Novel antioxidant makes old blood vessels seem young again
Older adults who take a novel antioxidant that specifically targets cellular powerhouses, or mitochondria, see age-related vascular changes reverse by the equivalent of 15 to 20 years within six weeks, according to new University of Colorado Boulder research.
https://www.sciencedaily.com/releases/2018/04/180419141523.htm
i'm a doctor, i take mitoq 10mg(2caps morning) for like 3 years already, EOD or when i remember, 80% of time after i take 2 pills 2-3hours later a receive headache and drowsiness...so 20mg will be not good for me....
and i saw all this studies.... in my case wrinkles(33-36y.o+ also after several month on minoxidil) not goes away even on mitoq+tam818+skq1....and my grandmother died of chronic heart insufficiency/copd after 2 years on mitoq+tam818+skq1. also in case of grandmother mitoq not stop septic cystitis!!! but there are articles where it miracly cured sepsis....
i also like to point! no hair regrowth and no better vision, regress of vision goes slowly on.
deuterium depleted water -4-5 years on it, great for exercises and calm but no hair regrowth/no better vision/no regress in wrinkles.....
in my case and my grandmother case i clearly saw effect after NAD+ in life extension or similar Basis... but only on physical/energy aspects, not on hair....
We all want a simple binary answer to aging, the magic pill but it is more complicated than this...
I personally takes mitoQ 20mg + Pyrroloquinoline quinone 40mg everyday.
As males we should all take the linus Pauling protocol .. High dose of Vitamin C + L-lysine L-proline to prevents the LP(a) to stick to the arteries..
Also high dose of Vitamin K2.. Mk7 or MK4 is a must to prevents calcification and stiffness of arteries.
Cool study on K2..
Press Release 12/19/2013: MenaQ7® Vitamin K2 Supplementation May Benefit Dialysis Patients by Inhibiting Vascular Calcification
NattoPharma has announced the publication of a new study performed in collaboration with OLV Hospital, Belgium, St. Jan Hospital, Belgium and VitaK, University of Maastricht, the Netherlands, published by Nephrology Dialysis Transplantation. doi: 10.1093/ndt/gft464 .
Haemodialysis patients suffer from early and accelerated vascular calcification which is predictive for cardiovascular disease and all-cause mortality in this population. The vitamin K-dependent matrix GLA protein (MGP) is one of the most potent inhibitors of vascular calcification, and Dialysis patients have high levels of the inactive form, or undercarboxylated MGP. Thus, this patient population may benefit from Vitamin K2 as menaquinone-7 supplementation to activate MGP and prevent vascular calcification.
“Vascular calcification is a significant problem for dialysis patients. In fact, without transplant, it could be considered a terminal condition for this population. Our hope is that Vitamin K2 supplementation may slow this process and improve not only the quality, but quantity of life for these patents, ” says investigator An S. De Vriese of the Division of Nephrology and Infectious Diseases, AZ St.-Jan Hospital.
Previously vascular calcification was considered to be an entirely passive process. However it is now widely recognized that it is an actively regulated process implying death and damage of vascular smooth muscle cells (VSMCs) and transformation of these cells into osteoblast-like cells (bone producing cells). Deficiencies in calcification inhibitors – where carboxylated (active) MGP is one of the strongest, and where Vitamin K2 activates MGP – are major explanations for calcification in the vessel wall.
To determine the optimal dose of Vitamin K2 as menaquinone-7 (MK-7) for MGP activation, 200 chronic haemodialysis patients were recruited to randomly receive 360, 720 or 1080 μg of MK-7 (MenaQ7 ® ) three times weekly for 8 weeks. Vitamin K1 (phylliquone) and K2 from food sources was estimated based on a detailed questionnaire. Vitamin K1 was not associated with MGP activity. MK-7 levels in the patient groups were correlated with the reduction in the concentrations of inactive (undercarboxylated) MGP after 8 weeks. The reductions were 17, 33 and 46% in the respective K2 groups.
“This study demonstrates the benefits of vitamin K2 in the activation of MGP, a potent inhibitor of vascular calcification, ” says Hogne Vik, CEO of NattoPharma. “While dialysis patients are significantly prone to calcification, we know from population- and in vivo studies, that improving vitamin K2 status results in less arterial calcification and improved cardiovascular outcomes. A three-year interventional study with MenaQ7® actually showed an improvement in arterial elasticity in healthy postmenopausal women.”
The authors concluded that vitamin K2 supplementation may be a novel approach to prevent vascular calcifications in chronic haemodialysis patients.
It seems than nitric oxide plays a major factor in aging... Nitric Oxide controls Mitochondria biogenesis and Nitric Oxide is the cellular signal that tells stem cells to mobilize to repair damage. You can find many studies if you google Nitric Oxide and aging..
Getting enough CoQ10 in your diet not only preserves nitric oxide but can also help improve athletic performance, prevent migraines and promote heart health (18Trusted Source, 19Trusted Source, 20Trusted Source).
Vitamin K 2-MK-7 Improves Nitric Oxide-Dependent Endothelial Function in ApoE/LDLR -/- Mice
https://pubmed.ncbi.nlm.nih.gov/31421222/
Also
Study shows blood cells need nitric oxide to deliver oxygen..
https://www.medicalnewstoday.com/articles/292292
There is a cool product that just came out called Pneuma that delivers nitric oxide transdermally.
https://www.pneumanitricoxide.com/
Fun fact.. Topical Nitric Oxide is a first class local Anti androgen:
http://www.novan.com/files/8613/7398/9326/Topical_nitric_oxide_local_androgen_therapy.pdf
Should we take this stuff topically, lol? Ah, just checked. This stuff is ultra expensive, haha
great information.While I think mito dysfunction is a complicating process in Androgenetic Alopecia, I wouldn't really call it the driver.
Reason:
in the human male to SCID mice study, just transplanting Androgenetic Alopecia follicles on that mouse wouldn't really solve any underlying mitochondrial problems by itself.
The transplant tho could have supplied a much better blood flow than what was present in the human scalp and THEN helped mito function.
So...I'm believing microcirculation problems are causing the subsequent problems we see in Androgenetic Alopecia.
We all want a simple binary answer to aging, the magic pill but it is more complicated than this...
so do You ready to post your results with photos?
i also use vitd3+k2(mk7)+solgar skin+hair complex(vitC+Lproline,lysine+msm)+magnesium=====>no visible result on hair, and i didn't loose weight....
about NO, good point, i see good results of energized dick and hair after L-arginine 1000-2000-3000. but after 21-30 days it's seems like habitability of the body and effects goes a bit down...