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Retinoic Acid And Wound-induced Hair Follicle Regeneration

Discussion in 'New Research, Studies, and Technologies' started by HairOnFire, Jul 12, 2019.

  1. HairOnFire

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    It appears that retinoids may have a critical role in wound-induced hair follicle neogenesis. I wonder if tretinoin will be in Follica's drug cocktail?

    Full text (gives much more detail than the abstract in terms of hair follicle regeneration):

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594970/

    Nat Commun. 2019 Jun 26;10(1):2811. doi: 10.1038/s41467-019-10811-y.

    Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.

    Abstract

    How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.
     
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  2. Jk1

    Jk1 Established Member My Regimen

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    This is great so we should all use minoxidil with tretinoin when microneedling?

    Their is in Ebay minoxidil with retin-a in their
     
  3. Seuxin

    Seuxin Established Member

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    Don't over hype retinoic acid and tretinoin.
    Lot of people tried it along with minoxidil, dutasteride, needling...no results. I use it too as powder in my minoxidil since 2 years...it saddly didn't help me....
     
  4. baldlygoing

    baldlygoing Established Member My Regimen

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    Were you needling at the same time? I think that is the key difference here. Products that didn't "work" in the past could've been because it wasn't effectively reaching the area it needed to reach.

    When you say a lot of people tried along with needling I have to disagree because there weren't "a lot" of people needling until recently. And "a lot" of people use things for 2 weeks and say it didn't work and give up. Tretinoin/retinoic acid could take a year or 2 because of the mechanism in which it works.
     
  5. Seuxin

    Seuxin Established Member

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    Try it....You will se the non-result...like VPA and others shit.
     
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  6. PeggyPeterson

    PeggyPeterson Established Member My Regimen

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    I made an almost identical thread to this a month ago -.- you people suck..

    Anyway, this fella at Johns Hopkins also thinks retinoids acid and wounding is worth investigating:

    https://clinicaltrials.gov/ct2/show/NCT03491267

    He co-patented some of Follicas stuff, which is why I have a niggling suspicion that the “existing drugs” Follica keeps mentioning includes Retinoic Acid.
     
  7. PeggyPeterson

    PeggyPeterson Established Member My Regimen

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    That’s science for you, you gotta try to disprove..
     
  8. sktboiboi

    sktboiboi Established Member My Regimen

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    Like come on man, tretinoin doesn't work n worse still, it will make u lose your hair . U can lose an entire temple within 2 weeks if u apply it there.

    The end result = smooth barren skin. The researcher said it himself, laser rejuvenation induces tretinoin production. That's what aesthetic laser treatments does: to smoothen n whiten the face, including hair bearing regions like the chin n forehead.

    Otherwise, I should have tegroen my hairline, in addition to having a whole forehead n face full of hair. I literally applied it everywhere from my neck up back then(except my orifices). While my face texture has changed permanently, my lost hair hasn't regrown.

    Come on man seriously, I have been on it for more than half a year know it full well myself.


    I repeat: Stop posting this bullshit about tretinoin.









    PS u can fucking easily get topical tretinoin cheaply from alldaychemist or even your GP(claim it's for your acne). Its jusy that simple
     
    #8 sktboiboi, Jul 14, 2019
    Last edited: Jul 14, 2019
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  9. tomJ

    tomJ Experienced Member My Regimen

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    I disagree. VPA was proven in multiple studies. I think we are doing something wrong.
     
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  10. Capone

    Capone Experienced Member

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    Also Isotretinon is known to cause hairloss
     
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