Rest in peace RT1640/Rivertown Therapeutics

[Ralph Wiggum]

I read this week that Rivertown Therapeutics is officially out of business which means there's one less potential remedy to look forward to. The results from RT1640 looked so impressive in the photos and it was said that it could even help reverse graying hair. Anybody have any idea on why they failed?

 

[werefckd]

I read this week that Rivertown Therapeutics is officially out of business which means there's one less potential remedy to look forward to. The results from RT1640 looked so impressive in the photos and it was said that it could even help reverse graying hair. Anybody have any idea on why they failed?




View attachment 153076

Different lighting: check
Different angle: check
Only one patient: check

 

[-G-]

Different lighting: check
Different angle: check
Only one patient: check

Agreed with all those points, but there is still legit more hair with an older patient.

 

[LouisSarkozy]

wasn't this basically minoxidil + some immunosupressant? wouldn't have chose to try this route anyway

 

[pegasus2]

Yes, it was just minoxidil and cyclosporin A. They are both very potent hair inducers, but they both have low response rates, so you might use both and still get no hairs, or you might end up lucky like that guy in the pic.

 

[KNemo]

I read this week that Rivertown Therapeutics is officially out of business which means there's one less potential remedy to look forward to. The results from RT1640 looked so impressive in the photos and it was said that it could even help reverse graying hair. Anybody have any idea on why they failed?

Not finding enough money? For some reason there's no money in alopecia.

Yes, it was just minoxidil and cyclosporin A. They are both very potent hair inducers, but they both have low response rates, so you might use both and still get no hairs, or you might end up lucky like that guy in the pic.

Minoxidil, cyclosporin A, and a FKBP52 activator. If there's something in it it's in the combination.

 

[pegasus2]

Their own compound likely added nothing to the mix.

 

[KNemo]

Their own compound likely added nothing to the mix.

While possible there's not enough information to say. Minoxidil plus cyclosporine can likely be reduced to minoxidil only, topical cyclosporine isn't proven efficient for hair growth.
I guess we'll never know now.

 

[Will Be an Egg in 5 years]

Different lighting: check
Different angle: check
Only one patient: check

Exactly.

 

[KNemo]

Exactly.

There were several patients however the pictures available are lacking in consistency and patient data isn't available. Were they already on minoxidil? Had they tried minoxidil in the past? Did they use finasteride? Were there more patients with no results?
A good reason to be skeptical is that lack of documentation while doing a limited test seemingly suited to getting a patent hopefully pushing the value of a specific drug. Still think a proper trial with a larger group of people would've been interesting.

 

[werefckd]

Not finding enough money? For some reason there's no money in alopecia.


Minoxidil, cyclosporin A, and a FKBP52 activator. If there's something in it it's in the combination.

Dude, wake up. There is no lack of money in alopecia. The "no money" follows from the lack of effectiveness. That was and always is the real problem when it comes to the "promising" future hair loss treatments on the pipeline.

Those shitty results masked by manipulated unprofessional before/after pics may be enough to fool desperate baldies on the forums on the Internet. But real investors will of course laugh when they see those things. Thus, "no money".