Research Thread: Assessing Health Risks Of Stem Cell Treatments

[Ted Buckland]

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[Jonnyyy]

Safety concerns have been raised over the potential for mutations involved in stem cell treatments. the public release of a new treatment in japan, involves the public being monitored for 5 - 7 years after treatment as if they were part of the safety trial.

How safe is it?
Is there a significant cancer risk?
Whats the precedent here?

Any information positive or negative should be posted here. please contributed scholarly sources, or at least a decent standard of reporting from any cited sources.

here's an article to get us started, on the cancer risk of iPSC:
http://www.the-scientist.com/?articles.view/articleNo/45422/title/iPSCs-and-Cancer-Risk/

There's an article which found no mutation that could turn into cancer in their study here, 2016 by the way. All the other articles I find are of 2010 or before stating that there might be a chance they mutate into cancer. https://www.google.com/amp/www.the-scientist.com/?articles.amp/articleNo/45422/title/iPSCs-and-Cancer-Risk/

 

[kawnshawn]

Safety concerns have been raised over the potential for mutations involved in stem cell treatments. the public release of a new treatment in japan, involves the public being monitored for 5 - 7 years after treatment as if they were part of the safety trial.

How safe is it?
Is there a significant cancer risk?
Whats the precedent here?

Any information positive or negative should be posted here. please contributed scholarly sources, or at least a decent standard of reporting from any cited sources.

here's an article to get us started, on the cancer risk of iPSC:
http://www.the-scientist.com/?articles.view/articleNo/45422/title/iPSCs-and-Cancer-Risk/

I'm guessing that this is about Sheisido and replicel in regards to the the treatment in Japan and you heard it from Hellouser? I hope they still allow foreigners to be able to purchase the treatment, since it would be harder to monitor them since they live outside the country.

 

[Jonnyyy]

I'm guessing that this is about Sheisido and replicel in regards to the the treatment in Japan and you heard it from Hellouser? I hope they still allow foreigners to be able to purchase the treatment, since it would be harder to monitor them since they live outside the country.

I think Replicel uses a different cell this is in regards to Tsuji and Riken.

 

[BaldyBalderBald]

The main problem about iPSC was that they used to reprogram somatic/embryonic cells using exogenetic gene expression with retroviruses vectors, leading to potential tumorous adverse effects.
The new wave of iPSC is now using RNAs and proteins, way more safer and no significant adverse effects.

"As another way to avoid introducing genetic material, introducing reprogramming factors such as RNAs or proteins has attracted much attention. Indeed, the direct delivery of synthetic mRNAs has been shown to successfully reprogram somatic cells to a pluripotent state. In this study, in vitro transcribed RNAs were modified to avoid the endogenous antiviral cell defense. As a result, this method achieved a higher iPSC generation efficiency than the original retrovirus system. Successful reprogramming of somatic cells has also been achieved using microRNAs, whereby expression of the miR302/367 cluster containing five different miRNAs, miR302a/b/c/d and miR367, reprogrammed human fibroblasts more efficiently than previous retrovirus systems. Such RNA-based reprogramming avoids both breaks in existing genes and the reactivation of transgenes. Therefore, these methods hold much promise as novel iPSC generation methods that could be applicable for clinical use."

Methods of induced pluripotent stem cells for clinical application
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300922/

Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
http://onlinelibrary.wiley.com/doi/10.5966/sctm.2015-0017/full

 

[ThanksGramps]

Tsuji/Riken are using patient-derived induced pluripotent stem cells, also called autologous iPSCs, they don't even need to use embryonic cells anymore, the safety profile is even more promising.

Tsuji/Riken are NOT using iPSCs. They're using patient derived adult epithelial stem cells and mesenchymal stem cells, which are not iPSCs.

Riken conducts separate research into growing hair-bearing skin using iPSCs (like this, for example: https://www.theverge.com/2016/4/1/11346270/skin-stem-cells-lab-grown-hair-glands-riken-tissue) but it is unrelated to their hair primordiums work and is many years away.

 

[BaldyBalderBald]

Tsuji/Riken are NOT using iPSCs. They're using patient derived adult epithelial stem cells and mesenchymal stem cells, which are not iPSCs.

Riken conducts separate research into growing hair-bearing skin using iPSCs (like this, for example: https://www.theverge.com/2016/4/1/11346270/skin-stem-cells-lab-grown-hair-glands-riken-tissue) but it is unrelated to their hair primordiums work and is many years away.

My bad

http://www.cdb.riken.jp/en/news/2016/researches/0422_8737.html

Now, a research team headed by Takashi Tsuji, Team Leader of the Laboratory for Organ Regeneration, has reported the successful generation of skin tissue complete with appendage organs such as hair follicles and sebaceous glands from induced pluripotent stem cells (iPSCs).

 

[Jonnyyy]

My bad

http://www.cdb.riken.jp/en/news/2016/researches/0422_8737.html

Now, a research team headed by Takashi Tsuji, Team Leader of the Laboratory for Organ Regeneration, has reported the successful generation of skin tissue complete with appendage organs such as hair follicles and sebaceous glands from induced pluripotent stem cells (iPSCs).

Anyway, you got your answer Ted

What can this man not do? Damn tsuji

 

[NewUser]

So we're good again.right...? haha

...next question, would you move to japan if you had to?

We shouldn't have to if this procedure is commercialized, which is exactly what Replicel-Shiseido plan to do if RCH-01 works out. Riken-Kyocera would be crazy to want to keep it a Japanese procedure only. Makes no business sense whatsoever. If Tsuji's method works and can written up as a medical procedure and repeated in labs anywhere else in the world, then look for it happening everywhere else in the world is my guess. That includes all those Asian countries where the dollar goes a lot further than Japan. By some quirk of economics, we should be able to get the procedure relatively cheap compared to Japan with one of the highest costs of living, and of doing business, in the world.

...what about the Kim? (NOT SRS)

My guess is that this isn't about North Korea having one or two nuclear weapons. Not even close. Consider a seven-foot tall basketball player shrieking at the sight of a mouse. It's ridiculous. They want us to be afraid of a tiny country the size of Mississippi. I'm not afraid. Are you?

 

[NewUser]

It doesn't matter how big the country is. It matters how effective a nuclear strike would be on Japan... And yes if I was In japan and those nuclear sirens went off, and the missile whistled through the clouds making it's descent,.. I would be f*****g shitting my pants.

The missile tests were a counter to the 3 week-long joint-military drills in South Korea which involved 75,000 combat troops, along with hundreds of tanks, armored vehicles, landing craft, heavy artillery, a full naval flotilla and flyovers by squadrons of state of the art fighters and strategic B1B bombers. Do you think the North was a little rattled by all of that happening? It's simple, stop scaring the sh*t out of a tiny country the size of Mississippi, and the pop bottle rocket tests over Hokkaido Island will likely cease and desist.