Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product

waynakyo

Experienced Member
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Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, prospective, vehicle-controlled double-blind study in men

Background: Considerable parts of the global population are affected by androgenetic alopecia (Androgenetic Alopecia).
Aims: The efficacy of a foam containing nicotinic acid hexyl ester, polyphenols, zinc, glycine, and caffeine in comparison with a vehicle control foam was assessed in a double-blind vehicle-controlled study in men with Androgenetic Alopecia over 6 months.
Patients/methods: Sixty-two men with Androgenetic Alopecia were assigned either to the active ingredients (verum) or the vehicle group. They applied the products twice daily on affected scalp areas over 6 months. Automated phototrichograms were obtained at baseline, after 3 and 6 months. In addition, a clinical rating by a dermatologist and by the subjects themselves was documented using standardized questionnaires.
Results: The reduction of the telogen rate from T0 to T6 was significantly stronger in the verum group compared to the vehicle group. The reduction was significant from T0 to T3 and T6 in the verum group, but in the vehicle group only from T0 to T3, not to T6. Significantly increased hair density was noticed in both groups at all time points, but the change from T0 to T6 did not differ significantly between the groups. Cosmetic acceptance of the foam and its application regimen was generally good in both groups. Slight reddening and burning after application of verum in six cases was probably due to the presence of hexyl nicotinate.
Conclusion: The study demonstrated a reduction of the telogen rate by a cosmetic foam in men affected by Androgenetic Alopecia, indicating a benefit for cosmetic intervention against male pattern hair loss.
Keywords: androgenetic alopecia; claim substantiation; hair growth; hair treatment; telogen rate.
© 2021 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
 

inmyhead

Senior Member
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The improvement in hair density within the observation time of 6 months is illustrated in exemplary TrichoScan images from 2 subjects from the verum group at T0 and T6 (Figure 3). In the verum group, a significant increase in hair density was observed from T0 (171.3/cm2) to T3 (217.0/cm2) (p < 0.001) and from T0 (171.3/cm2) to T6 (200.6/cm2) (p = 0.001). The vehicle group also experienced a significant increase in hair density from T0 (179.7/cm2) to T3 (217.4/cm2) (p < 0.001) and from T0 (179.7/cm2) to T6 (202.1/cm2) (p = 0.04) (Figure 4). No statistically significant difference existed between verum and vehicle with regard to the change in hair density from T0 to T6.

I don't understand something. Here they claim that hair density is the same in vechile and verum group? So what's the deal then? Vechile is responsible for increased density? Or shitty calculations and thing itself is ueless? I remember fluridil had same amount of hair increase in vechile/fluridil group.
 

waynakyo

Experienced Member
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464
They claim that the product reduces telogen significantly more than the "placebo" (which isn't a placebo)
And they claim that the product improves density but much more significantly than placebo

Either the vehicle foam does something on its own,
or both don't do much,
or there is noise related to what pegasus said
 
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