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All right yall! I NEED yalls full undivided attention! GATHER 'ROUND! So earlier today I was doing my usual hairloss research and recently seen a post on reddit in regards to "growing new body parts" and it linked a article which would be this link here.
Now listen I know what yall are thinking "Strictly why are you mentioning this? The goal is to cure androgenetic alopecia and get our hair back not regrowing body parts!"
First and foremost I fully understand the questions and skepticism! This whole thing of baldness and hairloss has been a mystery for such a long time and has been existing before any of us were born. And there's often people who infiltrate the community and basically look at us like dollar signs and fineness some of us. So I get it!
But basically in the article they discovered that 15-PGDH (15-Hydroxyprostaglandin Dehydrogenase) was the main pathway in osteoarthritis/rheumatoid arthritis because this pathway is literally responsible is for not only the degradation of brown fat tissue / adipose / subcanteous fat of out body but it also stops the PROSTAGLANDIN E2 PATHWAY! In the article they used a A.I. based program and found out about the 15-PGDH pathway and how it accelerates aging and its degrading affects of muscles and inducing arthritis etc in young mice [yes i know] that had no active 15-PGDH pathway activity. Well they came up with a drug that blocks the 15-PGDH pathway and when that happened they found that they regenerated muscles and the fat / cushioning that bones needed to basically stay healthy and youthful! And as we age it's been discovered that this protein 15-PGDH builds up!
(Sidenote: As of late I've been noticing a strange connection between osteoporosis/arthritis and androgenetic alopecia and this article seems to connect these two pathways together in a way, think about it - it's well known that the fat tissue [ brown fat / subcutaneous fat ] of the scalp is non existent in bald follicles & recessed / thin areas when that degrades things go from bad to worst and I highly suspect that 15-Hydroxyprostaglandin Dehydrogenase is the key player in this! I also wonder if benoxaprofen A infamous and banned nsaid drug that was made to stop arthritis which it successfully did but it also triggered hypertrichosis and reversed androgenetic alopecia and sped up the growth rate of hair but this drug also k!lled people. But i cant help but to wonder now if this drug somehow inhibited the 15-PGDH pathway i do know it was a mild cox inhibitor but inhibiting cox pathways full blown is definitely not something we want to do because if we inhibt both cox pathways we would inhibit PG-E2 which is oh so important for the scalps environment!)
Now - The prostaglandin E2 pathway has been brought up time and time again within the hairloss community the most famous case being Swisstemples (we love you bro! Thanks for putting together a protocol and finding a major peice to the puzzle) his protocol focused on stimulating this pathway and he literally started growing his corners and temples back but he unfortunately stopped the routine due to several reasons! It wasn't health related sides but more so that making the pg-e2 solution was a everyday thing due to how unstable it was the minute hit hit light or got any air it would degrade! Secondly it was way too expensive! Thirdly it's very hard to source! So with all that being laid on the table he stopped the routine and maintains with dutasteride! But prostaglandin E2 this pathway plays a significant role in hair health!
Pg-e2 repairs damage tissue and stimulates stem cells of the scalp! So this is a VERY VERY VERY important pathway for our hair! Here's a article talking about the 15-Hydroxyprostaglandin Dehydrogenase pathway it's affect on endothelial health and talks about the prostaglandin E2 pathway! https://www.mdpi.com/1420-3049/31/1/123
Guys definitely read the articles I listed! Give me thoughts and opinions! I don't wanna make this too long winded at the moment may add some more things to this post later but what I have now should give yall a general idea of how this could be a major help for us!
Now listen I know what yall are thinking "Strictly why are you mentioning this? The goal is to cure androgenetic alopecia and get our hair back not regrowing body parts!"
First and foremost I fully understand the questions and skepticism! This whole thing of baldness and hairloss has been a mystery for such a long time and has been existing before any of us were born. And there's often people who infiltrate the community and basically look at us like dollar signs and fineness some of us. So I get it!
But basically in the article they discovered that 15-PGDH (15-Hydroxyprostaglandin Dehydrogenase) was the main pathway in osteoarthritis/rheumatoid arthritis because this pathway is literally responsible is for not only the degradation of brown fat tissue / adipose / subcanteous fat of out body but it also stops the PROSTAGLANDIN E2 PATHWAY! In the article they used a A.I. based program and found out about the 15-PGDH pathway and how it accelerates aging and its degrading affects of muscles and inducing arthritis etc in young mice [yes i know] that had no active 15-PGDH pathway activity. Well they came up with a drug that blocks the 15-PGDH pathway and when that happened they found that they regenerated muscles and the fat / cushioning that bones needed to basically stay healthy and youthful! And as we age it's been discovered that this protein 15-PGDH builds up!
(Sidenote: As of late I've been noticing a strange connection between osteoporosis/arthritis and androgenetic alopecia and this article seems to connect these two pathways together in a way, think about it - it's well known that the fat tissue [ brown fat / subcutaneous fat ] of the scalp is non existent in bald follicles & recessed / thin areas when that degrades things go from bad to worst and I highly suspect that 15-Hydroxyprostaglandin Dehydrogenase is the key player in this! I also wonder if benoxaprofen A infamous and banned nsaid drug that was made to stop arthritis which it successfully did but it also triggered hypertrichosis and reversed androgenetic alopecia and sped up the growth rate of hair but this drug also k!lled people. But i cant help but to wonder now if this drug somehow inhibited the 15-PGDH pathway i do know it was a mild cox inhibitor but inhibiting cox pathways full blown is definitely not something we want to do because if we inhibt both cox pathways we would inhibit PG-E2 which is oh so important for the scalps environment!)
Now - The prostaglandin E2 pathway has been brought up time and time again within the hairloss community the most famous case being Swisstemples (we love you bro! Thanks for putting together a protocol and finding a major peice to the puzzle) his protocol focused on stimulating this pathway and he literally started growing his corners and temples back but he unfortunately stopped the routine due to several reasons! It wasn't health related sides but more so that making the pg-e2 solution was a everyday thing due to how unstable it was the minute hit hit light or got any air it would degrade! Secondly it was way too expensive! Thirdly it's very hard to source! So with all that being laid on the table he stopped the routine and maintains with dutasteride! But prostaglandin E2 this pathway plays a significant role in hair health!
Pg-e2 repairs damage tissue and stimulates stem cells of the scalp! So this is a VERY VERY VERY important pathway for our hair! Here's a article talking about the 15-Hydroxyprostaglandin Dehydrogenase pathway it's affect on endothelial health and talks about the prostaglandin E2 pathway! https://www.mdpi.com/1420-3049/31/1/123
Guys definitely read the articles I listed! Give me thoughts and opinions! I don't wanna make this too long winded at the moment may add some more things to this post later but what I have now should give yall a general idea of how this could be a major help for us!