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One recent study published in Neuroendocrinology found that after 20 days of finasteride exposure, male rats showed altered levels of a whole host of neurosteroids and receptors in their brains. Thirty days after going off the drug, the changes were more pronounced than when they were on the drug.
Studies in humans have only just begun, at Baylor, Boston University, and elsewhere, so it's way too early to draw firm conclusions. But the theory surrounding what some patients call "the crash" goes something like this: Cells in the brain and genitals are starved of important hormones while on the drug, so they grow more receptors to sop up all that they can get. Once the drug is discontinued, the hormones come flooding back with more than the cells can handle, which hurts or kills them. "Essentially, the cells get too much DHT, it puts them in overdrive and it burns them out," says Jacobs. So even if the body starts making all those missing compounds again, the tissue has trouble using them.
Jacobs stresses that, in his experience working with hundreds of patients, the vast majority do get better. "No one person goes through it the same," he says. "But unfortunately, in some men, the damage is hardwired.""
https://tonic.vice.com/en_us/articl...y-behind-americas-best-selling-hair-loss-drug
Thus i think it might be better to slowly go done with the dosis instead of quitting from today to tommorow
One recent study published in Neuroendocrinology found that after 20 days of finasteride exposure, male rats showed altered levels of a whole host of neurosteroids and receptors in their brains. Thirty days after going off the drug, the changes were more pronounced than when they were on the drug.
Studies in humans have only just begun, at Baylor, Boston University, and elsewhere, so it's way too early to draw firm conclusions. But the theory surrounding what some patients call "the crash" goes something like this: Cells in the brain and genitals are starved of important hormones while on the drug, so they grow more receptors to sop up all that they can get. Once the drug is discontinued, the hormones come flooding back with more than the cells can handle, which hurts or kills them. "Essentially, the cells get too much DHT, it puts them in overdrive and it burns them out," says Jacobs. So even if the body starts making all those missing compounds again, the tissue has trouble using them.
Jacobs stresses that, in his experience working with hundreds of patients, the vast majority do get better. "No one person goes through it the same," he says. "But unfortunately, in some men, the damage is hardwired.""
https://tonic.vice.com/en_us/articl...y-behind-americas-best-selling-hair-loss-drug
Thus i think it might be better to slowly go done with the dosis instead of quitting from today to tommorow
