reactionary increase in 5ar receptors, why so little info?

[Diddy]

I can never seem to find any literature examining the effects these drugs have on 5ar receptors? I mean studies have hinted that the body may produce more 5ar receptors to combat the decrease in DHT. Furthermore although rare, hyperadrogencity (also very understudied, can't seem to find any studies really on this either) is also reported as a responce to DHT inhibition, in which the body creates more 5ar receptors.

The reason i bring this up, is because i was overhearing a conversation while waiting at my Doctor's office, in which this guy Did like a ton of Extasy or something and was now permanantly tripping out all the time, moody and sh*t. The Doctor basically said that Extasy temporary lowers the usually permanent seratonin supply or something vital to the brain. In responce for protection the body may increase the amount of receptors, and then when levels go back to normal, you are hypersensitive to the stuff. I felt bad for the guy... the Doctor was saying some people have to take meds for life because of this...

Now mind you i could barely hear what he was talking about, but this is the gist of it. Now i ask because the body ain't dumb, and i wonder if over time, some of this "weening" effect of propecia effectiveness is due to an increase in the # of 5ar receptors.

Anyone have any ideas? Something i've always wondered. The body is pretty damn adaptable....It always counterbalances excess anything...

 

[Robuk]

I can never seem to find any literature examining the effects these drugs have on 5ar receptors? I mean studies have hinted that the body may produce more 5ar receptors to combat the decrease in DHT. Furthermore although rare, hyperadrogencity (also very understudied, can't seem to find any studies really on this either) is also reported as a responce to DHT inhibition, in which the body creates more 5ar receptors.



This may have a bearing on a lot of disorders.As you say the body compensates when things go out of balance, though cannot as readily re-adapt when things return to normal.This could be why it has up to now not been possible to reverse male pattern baldness long term once it has started.It could explain why many conditions affecting hormonal or immune system changes seem to trigger male pattern baldness as the body has adapted to the initial change but cannot reverse the process once things return to normal.I cannot seem to find much info on what actually affects levels of 5-ar or indeed it's receptors
Rob

 

[Jack_the_Lad]

Thats a good point, I wouldn't mind an answer to this. I think this could explain why alot of guys get side effects from 5AR inhibition at first, but then they disappear with continued use.

 

[HairlossTalk]

Diddy -

Can you expound a bit more on why you feel the way you feel on this topic? Give more examples, references, etc? Im interested in it and think it might make for an interesting article in our next newsletter, but would want to have more material to give the scientist I ask to write about it. How does it relate to hair loss? Jack kind of tied it in there at the end, but im also interested in your thoughts.

HairLossTalk.com

 

[Bryan]

Re: reactionary increase in 5ar receptors, why so little inf

I can never seem to find any literature examining the effects these drugs have on 5ar receptors? I mean studies have hinted that the body may produce more 5ar receptors to combat the decrease in DHT. Furthermore although rare, hyperadrogencity (also very understudied, can't seem to find any studies really on this either) is also reported as a responce to DHT inhibition, in which the body creates more 5ar receptors.

There's no such thing as a "5ar receptor". What you're talking about is an ANDROGEN receptor.

Bryan