Randomized Trial Of Electrodynamic Microneedle Combined With 5% Minoxidil Topical Solution

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Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia.

Authors:
Bao L; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Gong L; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Guo M; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Liu T; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Shi A; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Zong H; b Department of Neonatology , Shenzhen Maternity and Child Care Hospital , Shenzhen , China.
Xu X; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Chen H; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Gao X; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Li Y; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
Source:
Journal Of Cosmetic And Laser Therapy: Official Publication Of The European Society For Laser Dermatology [J Cosmet Laser Ther] 2017 Oct 13. Date of Electronic Publication: 2017 Oct 13.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4180 (Electronic) Linking ISSN: 14764172 NLM ISO Abbreviation: J Cosmet Laser Ther
Imprint Name(s):
Publication: London : Informa Healthcare
Original Publication: London : Martin Dunitz, c2001-
Abstract:
Background: In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth.
Objective: A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution.
Methods: Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20). A total of 12 microneedle treatments were performed every 2 weeks with 2ml 5% minoxidil delivery in group 3 during each microneedle treatment. Patient receiving topical 5% minoxidil applied 1 ml of the solution twice daily over the course of the study. A total of 60 Chinese male subjects with Norwood-Hamilton type III-VI androgenetic alopecia were treated.
Results: The mean improvement in total hair density from baseline to 24 weeks was 18.8/cm2 in group 1, 23.4/cm2 in group 2, and 38.3/cm2 in group 3. The hair growth in the 3 groups was significantly different (P = 0.002), but there were no significant differences in toxicity found between the 3 groups.
Conclusions: Treatment with microneedle plus topical 5% minoxidil was associated with the best hair growth.
Contributed Indexing:
Keywords: Androgenetic alopecia; Chinese; microneedle; minoxidil
Entry Date(s):
Date Created: 20171013 Latest Revision: 20171013
Update Code:
20171016
DOI:
10.1080/14764172.2017.1376094
PMID:
29028377