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Randomized Trial Of Electrodynamic Microneedle Combined With 5% Minoxidil Topical Solution

Discussion in 'Hair Loss and Alopecia Published Studies' started by alscarmuzza, Dec 13, 2017.

  1. alscarmuzza

    alscarmuzza Established Member

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    Randomized trial of electrodynamic microneedle combined with 5% minoxidil topical solution for the treatment of Chinese male Androgenetic alopecia.

    Authors:
    Bao L; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Gong L; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Guo M; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Liu T; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Shi A; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Zong H; b Department of Neonatology , Shenzhen Maternity and Child Care Hospital , Shenzhen , China.
    Xu X; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Chen H; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Gao X; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Li Y; a Department of Dermatology , The First Affiliated Hospital of China Medical University , Shenyang , China.
    Source:
    Journal Of Cosmetic And Laser Therapy: Official Publication Of The European Society For Laser Dermatology [J Cosmet Laser Ther] 2017 Oct 13. Date of Electronic Publication: 2017 Oct 13.
    Publication Type:
    Journal Article
    Language:
    English
    Journal Info:
    Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4180 (Electronic) Linking ISSN: 14764172 NLM ISO Abbreviation: J Cosmet Laser Ther
    Imprint Name(s):
    Publication: London : Informa Healthcare
    Original Publication: London : Martin Dunitz, c2001-
    Abstract:
    Background: In treating androgenetic alopecia, 5% minoxidil is a commonly used topical drug. By using electrodynamic microneedle at the same time may increase absorption of minoxidil and further stimulate hair growth.
    Objective: A 24-week, randomized, evaluator blinded, comparative study was performed to evaluate the efficacy of treating Chinese male androgenetic alopecia using microneedle combined with 5% minoxidil topical solution.
    Methods: Randomized subjects received topical 5% minoxidil (group 1, n = 20), local electrodynamic microneedle treatments (group 2, n = 20), or local electrodynamic microneedle treatments plus topical 5% minoxidil (group 3, n = 20). A total of 12 microneedle treatments were performed every 2 weeks with 2ml 5% minoxidil delivery in group 3 during each microneedle treatment. Patient receiving topical 5% minoxidil applied 1 ml of the solution twice daily over the course of the study. A total of 60 Chinese male subjects with Norwood-Hamilton type III-VI androgenetic alopecia were treated.
    Results: The mean improvement in total hair density from baseline to 24 weeks was 18.8/cm2 in group 1, 23.4/cm2 in group 2, and 38.3/cm2 in group 3. The hair growth in the 3 groups was significantly different (P = 0.002), but there were no significant differences in toxicity found between the 3 groups.
    Conclusions: Treatment with microneedle plus topical 5% minoxidil was associated with the best hair growth.
    Contributed Indexing:
    Keywords: Androgenetic alopecia; Chinese; microneedle; minoxidil
    Entry Date(s):
    Date Created: 20171013 Latest Revision: 20171013
    Update Code:
    20171016
    DOI:
    10.1080/14764172.2017.1376094
    PMID:
    29028377
     
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