Question About Effective DHT Inhibition

[RobbZer0]

Does this sound familiar to anybody? I've read that DHT, or enzyme 5aR, not sure which, has to be treated from two different "angles" in order to maximize the desirable inhibition of DHT and formation of 5aR. I'm not talking about enzyme 5aR converting from testosterone and forming into DHT as the two angles. But more about how to attack all the things that make up the source of DHT. I wish I could be more precise. I hope someone knows what I'm talking about.

 

[stampede]

Type one and type two.

Apparently, it's type two that causes hair loss, and type one screws up your skin.

finasteride blocks only type two, dutasteride blocks them both.

 

[Pondle]

Does this sound familiar to anybody? I've read that DHT, or enzyme 5aR, not sure which, has to be treated from two different "angles" in order to maximize the desirable inhibition of DHT and formation of 5aR. I'm not talking about enzyme 5aR converting from testosterone and forming into DHT as the two angles. But more about how to attack all the things that make up the source of DHT. I wish I could be more precise. I hope someone knows what I'm talking about.

In humans, Type I 5AR is predominant in the sebaceous glands of the skin and the liver. Type I 5?-reductase is responsible for approximately one-third of circulating DHT. Type II 5?-reductase is primarily found in the prostate, testes, hair follicles and the liver, and is responsible for two-thirds of circulating DHT.

Type I 5AR doesn't seem particularly significant in male pattern baldness. Pseudohermaphrodites with 5AR2 deficiency still have 5AR1, yet they don't lose their hair. The experimental 5AR1 inhibitor MK386 had no effect on hair growth in macaques.

 

[ripple-effect]

Robb Zero, you can attack DHT from two different angles by attacking internally and externally [e.g. Nizoral(external) Propecia(internal)]. Nizoral gets rid of scalp DHT and propecia gets rid of follicle DHT, although, I wouldn't recommend this combo b/c it didn't really work for me.

What is working for me is Revivogen Scalp Therapy(internal in the sense that leaving it in gets deep down into the follicle and blocks DHT which protect the follicle) and Revivogen biocleansing shampoo/conditioner + Nizoral(External - gets rid of about 5% of DHT, scalp therapy gets rid of about 95% both type I and II forms). It isn't working for regrowth but it is working by stopping my hair loss and thickening my existing hairs.

 

[purecontrol]

Does this sound familiar to anybody? I've read that DHT, or enzyme 5aR, not sure which, has to be treated from two different "angles" in order to maximize the desirable inhibition of DHT and formation of 5aR. I'm not talking about enzyme 5aR converting from testosterone and forming into DHT as the two angles. But more about how to attack all the things that make up the source of DHT. I wish I could be more precise. I hope someone knows what I'm talking about.

In humans, Type I 5AR is predominant in the sebaceous glands of the skin and the liver. Type I 5?-reductase is responsible for approximately one-third of circulating DHT. Type II 5?-reductase is primarily found in the prostate, testes, hair follicles and the liver, and is responsible for two-thirds of circulating DHT.

Type I 5AR doesn't seem particularly significant in male pattern baldness. Pseudohermaphrodites with 5AR2 deficiency still have 5AR1, yet they don't lose their hair. The experimental 5AR1 inhibitor MK386 had no effect on hair growth in macaques.

Very good information thank you, we are seeing less and less need for dutasteride

 

[RadioRaheem]

Robb Zero, you can attack DHT from two different angles by attacking internally and externally [e.g. Nizoral(external) Propecia(internal)]. Nizoral gets rid of scalp DHT and propecia gets rid of follicle DHT, although, I wouldn't recommend this combo b/c it didn't really work for me.

What is working for me is Revivogen Scalp Therapy(internal in the sense that leaving it in gets deep down into the follicle and blocks DHT which protect the follicle) and Revivogen biocleansing shampoo/conditioner + Nizoral(External - gets rid of about 5% of DHT, scalp therapy gets rid of about 95% both type I and II forms). It isn't working for regrowth but it is working by stopping my hair loss and thickening my existing hairs.

Interesting information you provided, in regards to Revivogen. I just added Revivogen back in June, so it's good to hear that it's working for you.

 

[Pondle]

Very good information thank you, we are seeing less and less need for dutasteride

Purecontrol, it's worth remembering that dutasteride inhibits 98.5 per cent of the DHT produced by 5AR2, compared to 90 per cent with 5mg finasteride. So the added value of dutasteride is not just its ability to inhibit 5AR1. The results we have so far suggest that dutasteride is better (in the case of 2.5mg/day, cosmetically much better) at regrowing hair over 6 months than finasteride. However, we don't have any long term data.

 

[purecontrol]

Very good information thank you, we are seeing less and less need for dutasteride

Purecontrol, it's worth remembering that dutasteride inhibits 98.5 per cent of the DHT produced by 5AR2, compared to 90 per cent with 5mg finasteride. So the added value of dutasteride is not just its ability to inhibit 5AR1. The results we have so far suggest that dutasteride is better (in the case of 2.5mg/day, cosmetically much better) at regrowing hair over 6 months than finasteride. However, we don't have any long term data.

I just wish I did not keep reading about people on dutasteride losing all their hair in the front. As for 2.5mg good luck to any that can affored that, just really not sure if 8.5% is satistically relevant to me.

Also the studies that CC posted showed that if anything dutasteride is not quite as good as finasteride.

The ony thing that throws a wrench into all this is the people have have had success with dutasteride LOL

 

[Pondle]

Also the studies that CC posted showed that if anything dutasteride is not quite as good as finasteride.

The ony thing that throws a wrench into all this is the people have have had success with dutasteride LOL

Haven't you seen my graphs? Over 6 months, 0.5mg/day dutasteride is more than 20 per cent better than 5mg/day finasteride. And 2.5mg/day dutasteride is about 36 per cent better.

 

[stampede]

Still too much that's unclear with all of this.

Pondle, putting your stats/graphs hat back on for a minute, do you reckon you could work out what hair counts would be if someone took:

1.25mg finasteride/day Sunday - Thursday
1.0mg dutasteride/day Friday and Saturday

I know that's a big ask, lol, but do you have any idea?

 

[Pondle]

Still too much that's unclear with all of this.

Pondle, putting your stats/graphs hat back on for a minute, do you reckon you could work out what hair counts would be if someone took:

1.25mg finasteride/day Sunday - Thursday
1.0mg dutasteride/day Friday and Saturday

I know that's a big ask, lol, but do you have any idea?

Jeez I wouldn't have the foggiest Stampede. :$ PM Bryan!

 

[stampede]

Still too much that's unclear with all of this.

Pondle, putting your stats/graphs hat back on for a minute, do you reckon you could work out what hair counts would be if someone took:

1.25mg finasteride/day Sunday - Thursday
1.0mg dutasteride/day Friday and Saturday

I know that's a big ask, lol, but do you have any idea?

Jeez I wouldn't have the foggiest Stampede. :$ PM Bryan!

LOL fair enough mate :mrgreen: sorry!