Q for Bryan re:hydrated scalp

[Red Rose]

According to Dr. proctor

"The general case is that hydrated skin absorbs drugs 2-20 times better than dry skin. It is also true of lipid-soluble drugs, tho perhaps not to the same extent. Also note the 10-fold range. Much depends on the particular agent."

I thought that applying revivogen to a hydrated scalp would impede the absorption of the fatty acids but now I'm not so sure.

Bryan?

 

[Red Rose]

Bump

 

[Bryan]

I'm not so sure, either. I acknowledge what Dr. Proctor said, especially the part about how hydration benefits the absorption of water-soluble substances more than fat-soluble ones. I think it may be a LOT more beneficial for the first than the second. I worried quite a bit specifically about what to do with Revivogen, and finally I just decided to follow their own instructions, and apply it to a dry scalp. But I'm not firmly convinced, one way or the other.

Bryan

 

[Dave001]

Very ironic timing. Just yesterday, I mentioned to Bryan the unexpectedly high level of penetration enhancement that hydration seemed to have on my solution of linoleic acid (LA), crudely quantified by the absence of the persistent, oily residue left behind from an application of LA to a dry scalp.

 

[Red Rose]

Very ironic timing. Just yesterday, I mentioned to Bryan the unexpectedly high level of penetration enhancement that hydration seemed to have on my solution of linoleic acid (LA), crudely quantified by the absence of the persistent, oily residue left behind from an application of LA to a dry scalp.

Interesting. Thats what I find with revivogen. The serum tends just to "sit" on the scalp when applied to a dry scalp.

Could it be that the reason revivogen results are so mixed is because people have been incorrectly advised by the makers to apply it to a dry scalp?

 

[Bryan]

It would be amazing if we're really onto something here, wouldn't it? :wink:

What I continue to find interesting is that of all the doctors who have written about hairloss and its treatment and posted about it on the Internet, Dr. Proctor appears to be the ONLY one who has emphasized the aspect of increasing the penetration of topicals through hydration. Why is that?? Dr. Khadavi (the designer of Revivogen) is certainly a dermatologist, so why does HE appear to be worried about hydrating the scalp prior to using Revivogen? I've seen Dr. Lee give rather grudging support to the concept of using hydration prior to topicals, but that's about it; I've never seen Drs. Sawaya or Price or anyone else mention it before, either, although they've authored studies on topical minoxidil and general review articles on hairloss treatment. Why is Dr. Proctor so exclusively associated with what _may_ be a significant treatment strategy?? :freaked:

Bryan

 

[Dave001]

It would be amazing if we're really onto something here, wouldn't it? :wink:

What I continue to find interesting is that of all the doctors who have written about hairloss and its treatment and posted about it on the Internet, Dr. Proctor appears to be the ONLY one who has emphasized the aspect of increasing the penetration of topicals through hydration. Why is that?? Dr. Khadavi (the designer of Revivogen) is certainly a dermatologist, so why does HE appear to be worried about hydrating the scalp prior to using Revivogen? I've seen Dr. Lee give rather grudging support to the concept of using hydration prior to topicals, but that's about it; I've never seen Drs. Sawaya or Price or anyone else mention it before, either, although they've authored studies on topical minoxidil and general review articles on hairloss treatment. Why is Dr. Proctor so exclusively associated with what _may_ be a significant treatment strategy?? :freaked:

I suspect the reason is that hydration introduces a variable of an "unknown value," and since Dr. Proctor is one of the very few (if not only) doctors using anything but the standard treatments, most doctors probably fear introducing any variables to what is described in the standard medical texts. It is also of importance to note that Dr. P is also a pharmacologist, whereas these other doctors probably have little knowledge of the kinetics involved in drug absorption and distribution. Finally, there is also the fact that enhancing the penetration of all topical drugs is not desirable, especially those for which a preexisting proclivity toward systemic absorption exists.

 

[Petchsky]

Maybe you are on to something... I started applying my minoxidil occasionally after showering and it just feels right. The minoxidil also dries at the same time as the hair, therefore cutting the drying time. Surly the more that gets into your system the better..up to a point of course.

 

[The Gardener]

I agree completely. After a year and a half of using topicals, I know for a fact that they absorb, and/or dry, a LOT faster on a recently-showered scalp versus a dry one.

It always seems that on nights I 'put off' my minoxidil application until later in the evening, the sh*t always just seems to sit there a lot longer. And, on those rare days when I skip my evening shower and just decide to go to bed, my pre-bedtime app on the scalp unshowered for 10 hrs or so really seems to go nowhere. It just doesn't FEEL like there is any absorbtion going on as compared to the normal days.

 

[Matgallis]

Take into account that apply topicals to damp or wet hair can cause the topical to combine with the water, become more dilluted and just evaporate...

Or maybe you're right.. Blah who knows

 

[goingoinbutnotgone]

True. The scalp must be "pat" dried with a towel so as to remove water.

But the issue with this is that the pores of the scalp are open when warmed and wetted. Pores will not open when cold water is applied. Only warm water. Being in a steamy room will also open pores.

 

[Red Rose]

I emailed revivogen and got this stock answer.

The application of Revivogen Scalp Therapy should be to a dry clean scalp. The application of the active ingredients will not be absorbed on a wet scalp since we utilize Liposomal Delivery System. The Liposomal Deliver System is made to be absorbed on a dry clean scalp since the ingredients are fatty acids.

Best Regards,

Revivogen Customer Service

 

[Dave001]

Take into account that apply topicals to damp or wet hair can cause the topical to combine with the water, become more dilluted and just evaporate...

Yes, that is correct; furthermore, there is no benefit to applying topicals to wet hair. If the water in itself were helpful, one might as well just reformulate the vehicle with more water. However, the enhanced penetration resulting from a hydrated scalp has nothing to do with water in the hair. The hair should not be wet.