pseudohermaphrodites, sebum production and male pattern baldness

[norwood4]

Hi, friends!
I´m new to the forum. It´s great to see that we have so much information to share and discuss; I also participate in a big forum in my country, Spain. I´m sure you will forgive me for any mistake I should make when writing my posts ; ))
I just wanted to start asking you a question which is intriguing me: why the guys who suffer from a congenital defficiency of 5AR-II don´t develop acne??? It´s understandable that they don´t develop male pattern baldness, as this isoenzyme is currently thought of as guilty being located in the dermal papilla, but don´t you think these guys should suffer from excesive sebum production if they still are plenty of 5AR-I???
Thanx for any info.

 

[HARM1]

Hi, friends!
I´m new to the forum. It´s great to see that we have so much information to share and discuss; I also participate in a big forum in my country, Spain. I´m sure you will forgive me for any mistake I should make when writing my posts ; ))
I just wanted to start asking you a question which is intriguing me: why the guys who suffer from a congenital defficiency of 5AR-II don´t develop acne??? It´s understandable that they don´t develop male pattern baldness, as this isoenzyme is currently thought of as guilty being located in the dermal papilla, but don´t you think these guys should suffer from excesive sebum production if they still are plenty of 5AR-I???
Thanx for any info.

I think 5AR2 is also the cause of ance. A drug that was a specific 5ARD-1 inhibitor was found to not help acne. the test was made by merc. REASONs FOR THAT MAY BE many. can be THAT 5AR - 1 is nof found in the cells in the face, or do not increase sebum.

 

[norwood4]

Hi, HARM1. Do you think that sebum production in the scalp is different from that in the face?
I think current theory is that DHT is both responsible, but it does lead to a contradiction when we face the study with the MK386 inhibitor (the one you were referring to). But maybe testosterone as well can make itslef and increment in sebum production, not needing to turn into DHT previously.
In both cases, we don´t have a satisfactory explanation of the fact that the guys I was talking about don´t suffer from acne.
Yours could be an explanation, but it doesn´t fit with the fact that 5AR2 is predominant in dermal papilla.
Do you have some evidence for your idea?
Maybe these guys are also androgen-insensitive to a certain degree???

 

[Bryan]

In both cases, we don´t have a satisfactory explanation of the fact that the guys I was talking about don´t suffer from acne.

The answer to your question is very simple: they DO get acne.

Bryan

 

[norwood4]

Thanx, Bryan!
In fact, the answer was really simple. But I had read many times that these guys didn´t suffer from acne! I suppose this was an erroneous information.
And how do we explain that they NEVER suffer from male pattern baldness? Maybe some DHT from the bloodstream could reach the follicles and start attacking them after all? In this case, we would need some kind of androgen insensitivity to avoid baldness.
Or this is just impossible and only "5AR2"-DHT in the dermal papilla can start male pattern baldness?

 

[Bryan]

Thanx, Bryan!
In fact, the answer was really simple. But I had read many times that these guys didn´t suffer from acne! I suppose this was an erroneous information.

Yes. Imperato-McGinley incorrectly reported in her first 1974 article in the journal Nature that they don't get acne, but later there were some cases of acne found among the "pseudohermaphrodites". I suspect that the Dominicans in general are somewhat less prone to acne than most other people due to various genetic and/or dietary and/or environmental factors, and the researchers simply incorrectly jumped to the conclusion that the pseudo's aren't susceptible to it AT ALL, just because they didn't notice any cases at the very beginning.

And how do we explain that they NEVER suffer from male pattern baldness? Maybe some DHT from the bloodstream could reach the follicles and start attacking them after all?
Or this is just impossible and only "5AR2"-DHT in the dermal papilla can start male pattern baldness?

I think that last thing you said is correct. In my opinion, DHT in the blood plays only a minor role in male pattern baldness. DHT made in the dermal papilla is the more important factor.

Bryan

 

[HARM1]

WELL :
Who's to say that sebum prodaction only happens because of DHT. DHT only increase sebum prodaction, but isn't the soul cause for it. for example also women have acne, and they almost have no DHT.

 

[Apoc]

Well acne isn't caused just by DHT so I don't think you can jump to a conclusion that people without DHT wouldn't get any.

 

[HARM1]

Well acne isn't caused just by DHT so I don't think you can jump to a conclusion that people without DHT wouldn't get any.

1) That's what I just said
2) THOSE guys still have DHT