squeegee
Banned
- Reaction score
- 132
Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.[SUP][1][/SUP][SUP][2][/SUP]
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH[SUB]2[/SUB]) to prostaglandin D2 (PGD[SUB]2[/SUB]). PGD[SUB]2[/SUB] functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD[SUB]2[/SUB] is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.[SUP][2][/SUP] Furthermore, PTGDS and its product PGD[SUB]2[/SUB] are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).[SUP][3][/SUP]
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH[SUB]2[/SUB]) to prostaglandin D2 (PGD[SUB]2[/SUB]). PGD[SUB]2[/SUB] functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD[SUB]2[/SUB] is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.[SUP][2][/SUP] Furthermore, PTGDS and its product PGD[SUB]2[/SUB] are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).[SUP][3][/SUP]
