Propecia (Finasteride) + Tamoxifen STUDY (Bryan!)

[amsch]

Staiman VR, Lowe FC.

Department of Urology, St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.

OBJECTIVES: Current therapies for advanced prostate carcinoma lead to a marked decrease in serum testosterone levels, which renders patients impotent. In preliminary studies, combination therapy with flutamide and finasteride has been used as an alternative therapy for the treatment of prostate carcinoma because potency can be preserved. Both of these agents can cause gynecomastia and breast/nipple tenderness. METHODS: Six men being treated for advanced prostate carcinoma with flutamide/finasteride combination therapy developed painful gynecomastia, which was treated with tamoxifen 10 to 30 mg/day for 1 month. Clinical follow-up included breast measurements and determination of prostate-specific antigen (PSA), testosterone, and estradiol levels. RESULTS: While on this combination therapy for prostate carcinoma, 4 of 6 patients experienced a decrease in PSA level to less than 0.5 ng/mL. All patients remained potent. Serum testosterone increased in each patient who had a baseline level drawn. Estradiol levels were noted to be elevated in 4 of 6 patients at the time of evaluation for gynecomastia. After treatment with tamoxifen, circulating estradiol levels increased in 3 patients from 1.3 to 2.2 times the baseline level. Five patients experienced complete resolution of breast and nipple pain on tamoxifen 10 mg/day within the first month. The other patient had to be treated with 30 mg/day for 1 additional month, which subsequently resulted in pain resolution. CONCLUSIONS: These preliminary results suggest that low-dose tamoxifen is useful in treating painful gynecomastia for those patients on flutamide/finasteride combination therapy for advanced prostate carcinoma.

PMID: 9426725 [PubMed - indexed for MEDLINE]




Any comments on this, bryan? I'd like to know what this means for the long run. I'd also like to know why Arimidex is considered safer than tamoxifen.

check out this too:
http://www.medhelp.org/posts/Erectile-D ... how/270261

 

[amsch]

bump for Bryan

 

[amsch]

bump for bryan.

 

[somone uk]

the problem is it was a hard push to get doctors to push the idea of finesteride for hairloss
and as far as i see all this proves is that tamoxifen inhibited estridol and made people have smaller boobs, which we already know because that's what tamoxifen is supposed to do

 

[amsch]

bump for bryan!

 

[amsch]

Bryan, I'm pretty sure you saw this topic already. could you please reply?

 

[amsch]

come on Mr. Shelton!

 

[amsch]

Bump for Bryan.

 

[somone uk]

hahaha, you really want him to reply

from the looks of the study it seems aimed towards people treating BPH rather than male pattern baldness, also because they are both perspiration meds it would mean you would technically need a prescription for both
pills have been fused before but their success is limited, paracetamol has been fused with Methionine in what is known as "paradote" the idea is simple, it helps minimise liver damage if an overdose is taken, this idea has been around for a while but you would find a hard job finding paradote, if a fusion on what is the most commonly taken drug is a failure this wouldn't really get a market.
it's a good idea mixing finasteride and tamoxifen together, but the amount of trials and the issues of FDA this and medical trial that would stop this from really getting anywhere
unfortunately this would be another event of red tape tightening a noose around the neck of a good idea
propecia hasn't given merk a massive success and only a fraction of the market would go for a "gyno free finasteride"