- Reaction score
- 15
Besides trying raloxifene & letrozole, anybody have experience applying a progesterone cream to their breast area? I read it competes with estrogen receptors there, but of course, have to be careful with dosage, as it can also make things worse if too much.
Considering it'd be easier overall. Guess I'll try, if nobody else has.
"Progesterone decreases expression of estrogen receptors in the breast tissues and also lowers the local level of active estrogens by stimulating production of enzymes (17-betahydroxysteroid dehydrogenase and estrone sulfotransferase) which oxidize estradiol into less active estrone and then by binding the latter transform it into inactive estrone sulfate. Thus, progesterone limits the proliferative action of estrogens on the breast tissues."
Considering it'd be easier overall. Guess I'll try, if nobody else has.
"Progesterone decreases expression of estrogen receptors in the breast tissues and also lowers the local level of active estrogens by stimulating production of enzymes (17-betahydroxysteroid dehydrogenase and estrone sulfotransferase) which oxidize estradiol into less active estrone and then by binding the latter transform it into inactive estrone sulfate. Thus, progesterone limits the proliferative action of estrogens on the breast tissues."
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