http://endo.endojournals.org/cgi/conten ... 108/4/1597
Kinetic evidence is presented for a time-dependent decrease in human placental aromatase activity by enzyme-generated intermediates derived from two widely used steroids previously described as competitive inhibitors of estrogen biosynthesis. Thus, 4-androstene-3,6,17-trione binds to the enzyme with an apparent Ki of 0.43 microM and has a pseudo- first order overall rate constant for decrease in activity of 4.03x10(- 3)sec-1, while 1,4,6-androstatriene-3,17-dione has an apparent Ki of 0.18 microM and a pseudo-first order overall rate constant for decrease in activity of 1.10x10(-3)sec-1. These findings imply that the potent inhibition of estrogen biosynthesis caused by these steroids results primarily from a decrease in enzyme activity caused by enzyme-generated intermediates from the parent steroids.
1,4,6-androstatriene-3,17-dione is the active ingredient in AIFM
This means that even if you apply it to your breats, it first must be converted to something else before it inhibits aromatase. Not sure where that conversion takes place, but it may mean that you can't just locally inhibit aromatase. AIFM may lower estrogen everywhere in your body equally.
But for $3, it is very cheap:
http://www.bulknutrition.com/p2189_1_4_ ... st400.html
Kinetic evidence is presented for a time-dependent decrease in human placental aromatase activity by enzyme-generated intermediates derived from two widely used steroids previously described as competitive inhibitors of estrogen biosynthesis. Thus, 4-androstene-3,6,17-trione binds to the enzyme with an apparent Ki of 0.43 microM and has a pseudo- first order overall rate constant for decrease in activity of 4.03x10(- 3)sec-1, while 1,4,6-androstatriene-3,17-dione has an apparent Ki of 0.18 microM and a pseudo-first order overall rate constant for decrease in activity of 1.10x10(-3)sec-1. These findings imply that the potent inhibition of estrogen biosynthesis caused by these steroids results primarily from a decrease in enzyme activity caused by enzyme-generated intermediates from the parent steroids.
1,4,6-androstatriene-3,17-dione is the active ingredient in AIFM
This means that even if you apply it to your breats, it first must be converted to something else before it inhibits aromatase. Not sure where that conversion takes place, but it may mean that you can't just locally inhibit aromatase. AIFM may lower estrogen everywhere in your body equally.
But for $3, it is very cheap:
http://www.bulknutrition.com/p2189_1_4_ ... st400.html