Probably the best topical news since ... well it´s

G

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hopefully good.

PSI(or 1) the product from osteoscreen or whatever they are called has been bought by a second party. They are investing 32mil usd.

PS1 has just finished phase one and is starting phase 2 or has started phase 2.

What the product does - grows hair like nothing todate - or so they claim. But still I don´t think that any company would spend 32mil usd on something that they didn´t belive in.
 

fallicule

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Probably a nieve question but....

How many phases are there?


I read something about this on an older post, does it work (or claim to work) in a way similar to minoxidil?

Thanks.
 

stax

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I read on Hairsite's forum that there are 3 phases and it probabbly wont be on the market for another 3 years or something by the time everything is done assuming the results are good.
 

Fallout Boy

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It says it grew hair alot faster then Rogaine ... and the hair was a lot thicker!!!! Thats fricking awesome news ... hopefully its as good as they say and it can be used and keep results longterm!! ON their website though it says phase 2 was supposed to start in late 2003?

OSH101’s hair growth effect was also compared to the hair growth effect of Rogaine®. The two groups were treated with OSH101 and Rogaine® respectively once per day for five days. After an additional sixteen days elapsed, hair growth was measured. OSH101 resulted in much faster and thicker hair growth than Rogaine®.
 

stax

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Here is an article i found on it:



PS1 is a cutting edge synthesized peptide for hair regrowth and new growth.

100mgs can last anywhere between 1 month and 3 months, depending on concentration. We are still trying to pin the optimal dosing down, but by most accounts, 100mgs should last a minimum of 1.5 months at once a day. Once you order you will be invited to our private PS1 forum to discuss details. Do to the experimental aspect of this product, we need to maintain a relative amount of confidentality so as not to compromise our source should it prove to be supremely effective. The other thing is that we aren't sure how long this product will have to be used. It is possible that the dosing will decrease as the results are realized, making only infrequent usage neccessary to maintain-and yes, it will be possible to reorder. I have a contact with one of the largest peptide firms in the US. Although the photos aren't yet publicly available, someone in the group of German users posted some pics that showed obvious improvements to the hairline after ony 23 days at a relatively low concentraton. The peptide is fully soluable in alcohol but not in water so it can simply be dissolved in alcohol then applied to the scalp.

As for the theory behind its use, I recommend conducting your own research. Check out Osteoscreen.com. They are a team of fully legitimate scientists pushing this full steam ahead through FDA trials. They have already completed phase one and are raising capitol for phase two. To me this is a strong indication of the potential of the treatment. Who is going to fund an experimental treatment based on theory alone? No one, there must obviously be some encouraging results, although Dr. Mundy has been very tight lipped about the matter, for obvious reasons. The science behind it is definitely there, this is the most cutting edge peptide in the entire known hairloss pipeline. Check out the posts from Martin B on the Hairsite forum-he was a trialist in the phase one trial in the Netherlands. This is no snakeoil. Will it grow a brand new full head of hair? Nobody knows yet. That's what we are going to find out.

As for the danger of tumors, believe what you will. I personally am utterly confident that no reputable scientist such as those employed by Osteoscreen would ever pursue a treatment that had risks like that. There are potentially thousands of peptides that inhibit different aspects of the proteasome, PS1 is just one of those. From what I can tell, all the gossip and useless information regurgitated by posters comes from second hand knowledge of a study that showed that a genetic modification, which permanently altered the proteosome activity within mice, ended up producing tumors. There is absolutely nothing surprising about this. The PS1 is a "reversible" inhibitor of a yet to be disclosed aspect of proteosome activity. This means that as long as you use it once a day or less, the proteasome will resume its activity as normal once the peptide is metabolized. As for safety, Martin B reported that the peptide was well tolerated by all trialists even at a high concentration of 5%.
 

fallicule

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oh wow this is awesome, made my night. finally something to look forward to that isnt 5-10 years down the road. good post.
 

too bald too furious

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More from the osteoscreen website :

OsteoScreen is developing its lead compound OSH101, a topical drug for the treatment of alopecia. OsteoScreen has initiated Phase I clinical trials (human toxicology studies with an endpoint in Q3-2003). OsteoScreen plans to take OSH101 into Phase II trials (dose ranging) later in 2003.

OsteoScreen identified OSH 101 as a candidate drug for hair re-growth in a proprietary screening program. In animal studies, it was observed that topical administration of OSH101 strongly stimulates dormant hair follicles, increases hair follicle thickness, and overall hair growth. The picture to the right demonstrates the increase in the size and thickness of hair follicles treated topically with OSH101 versus untreated controls. The purple colored bulbs are hair follicles. In the untreated control, the follicles remain small and inactive, while the follicles in the treated group were stimulated and show marked increase in their size and thickness. Treatment with OSH101 for 21 days re-grew healthy, thick hair; whereas the untreated control group barely began to re-grow any hair. OSH101 is a powerful stimulator of new hair growth.

OSH101’s hair growth effect was also compared to the hair growth effect of Rogaine®. The two groups were treated with OSH101 and Rogaine® respectively once per day for five days. After an additional sixteen days elapsed, hair growth was measured. OSH101 resulted in much faster and thicker hair growth than Rogaine®.

Another area of need is chemotherapy-induced hair loss. Many cancer patients who have undergone chemotherapy suffer from acute alopecia. It takes time for the hair to grow back, even after the chemotherapy has ended. The efficacy of OSH101 was determined in a model of chemotherapy-induced baldness. This model is well-described in the medical literature. OSH101 was applied to groups previously treated with cyclophosphamide (a widely-used chemotherapy) to induce hair loss. OSH101 stimulated extremely rapid hair re-growth compared to vehicle alone.

Details:

Indication:
Male and female pattern baldness

Technology:
OSH101 (drug for hair growth)

Intellectual Property:
OsteoScreen holds patents for the use of OSH101 for stimulating hair growth.

Development Plan:
OsteoScreen will develop OSH101 with the Center for Clinical and Basic Research (CCBR), a world renowned clinical Contract Research Organization located in Copenhagen, Denmark. The CCBR will perform the Phase I and Phase II Clinical trials at its facilities.

Status:
1. OSH101 significantly enhanced hair growth in laboratory models by stimulating dormant hair follicles.
2. OSH101 produced superior results to Rogaine® in the same models.
3. OSH101 enhanced hair re-growth in a chemotherapy-induced alopecia model.
4. Non-GLP pre-clinical toxicity studies showed OSH101 is safe.
5. Phase I clinical trials are underway.

Possible Indications:
1. Male and Female Pattern Baldness
2. Chemotherapy-induced alopecia.
3. Alopecia areata (autoimmune skin disease resulting in hair loss).
4. Age-related hair thinning.
5. Post-transplant hair re-growth.
 

flux

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I've been waiting for news on Osteoscreen!! Things have been so quiet, I started to get worried.

But this is great!!

Maybe I will have a nice thick head of hair in my 40's :D
Heres hopin five years from now my hair will look even better then it does now

Thanks Nesta!
 

stabone1979

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Peptides, protease huh, what the hell is in this stuff. Encouraging. Made my night too.
 

BadHairDecade

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I beleive they finished phase 1 over a year ago. So far i don't think there's anything new in this thread that hasn't been mentioned before. Actually that first cut and paste has been posted weeks ago.
There are other products that the company is working on too, so it's possible that's the reason for their newly found funding....I guess time will tell. Honestly, I ain't gettin my hopes up just yet.
 

Brasileirao

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They have already started Phase 2 and according to the Doctor Mundy, if things go well we might see something as early as next year.

Tony
 

Thinning

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That stuff is worthless. Some other company was promoting that stuff a year or two ago - they wanted people to spend $300 a month to take part in their trials. A few people did and had no noticable hair growth after 6 months. The whole peptide thing is a racket, it wont grow hair.
 

Fallout Boy

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Thinning said:
That stuff is worthless. Some other company was promoting that stuff a year or two ago - they wanted people to spend $300 a month to take part in their trials. A few people did and had no noticable hair growth after 6 months. The whole peptide thing is a racket, it wont grow hair.

anyone else feel this way?? im hoping this stuff is legit and does do what they claim it does.
 

stabone1979

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Nobody seems to know how legitamate PS1 is, if they are in phase 2 it should have produced some results.
 

thin=depressed

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flux said:
I've been waiting for news on Osteoscreen!! Things have been so quiet, I started to get worried.

But this is great!!

Maybe I will have a nice thick head of hair in my 40's :D
Heres hopin five years from now my hair will look even better then it does now

Thanks Nesta!
Yeah, maybe I'll have hair in my 40's as well. This drug is going to be so hyped by the time its ready for market that it will be gard to get and quite costly.
 

meintally

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Caution:

32 million isn't even close to what they are going to need to spend if this makes it to market.

The "test" results were evaluated after 16 days people.......16 days!!!

There are drugs currently on the market that have growing tumors as a side effect listed in thier package insert - commonly called a "Black Box Warning".

9 out of every 10 ethical pharmaceuticals that are evaluated fail. Many drugs fail in phase three and many more fail in phase two.

They mention the word "model" when referring to some early results. My experience tells me they are referring to computer models based off of theories - not actual test subjects. I may be wrong in this particular case, but generally when the term "model" is used in a study we arew talking about statitical data evaluations based on best, educated guesses.

They have'nt made any refernece to regeristing this drug with the FDA as a NDA. This is critical to protect thier patent rights.

Because of the extreme amount of money required to persue FDA approval, the risks involved and infastructure required to produce an ethical medication, it's highly unlikely any real hair loss medication will come from a small (32 million in captial, in pharmaceuticals is small) upstart company. I'm not saying it's not possible...just not very likely.
 

meintally

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BTW - I'm not trying to be a constant downer with these things. I just want to provide real-world context and perhaps play the devils advocate.
 

Fallout Boy

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meintally said:
BTW - I'm not trying to be a constant downer with these things. I just want to provide real-world context and perhaps play the devils advocate.

Just dont tell me that HM will never come out or wont be out for 30 years becuase thats my last hope ! of a cure.. haha
 
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