Nice graph btw, very nifty
From the actual avodart clincal trial that was abandoned by galaxo
Expert panel assessment of global photographs
The 3-member panel assessed paired photographs of baseline versus 12 and 24 weeks of treatment in both the vertex (Table II) and frontal (Table III) regions. Their assessments were given numeric values from −3 (greatly decreased compared with baseline) to +3 (greatly increased compared with baseline), in order to permit statistical analysis. In the vertex photographs, dutasteride (0.1, 0.5, and 2.5 mg) and finasteride showed significantly greater improvement than placebo (P < .001) at both 12 and 24 weeks (Fig 2, A). Dutasteride 0.5 mg showed a significantly greater improvement than finasteride at 24 weeks (P = .026), whereas dutasteride 2.5 mg showed significantly greater improvements than finasteride at both 12 and 24 weeks (P < .001). At 24 weeks, the mean expert panel score was −0.04, 0.19, 0.47, 0.84 and 1.01 points for placebo, 0.05-, 0.1-, 0.5-, and 2.5-mg dutasteride groups, respectively, and 0.62 points for finasteride (Fig 2, A). The percentages of patients judged to have improved hair growth (slightly to greatly increased) at 24 weeks in the vertex photographs were 2%, 15%, 39%, 63%, and 78% for placebo, 0.05-, 0.1-, 0.5 and 2.5-mg dutasteride groups, respectively, and 57% for finasteride (Table II). The panel assessments of the vertex photographs correlated with changes in hair counts assessed by macrophotography (r = 0.41, P < .001).
Also....
Subjects' assessment
In general, the 0.1-, 0.5-, and 2.5-mg dutasteride groups and the finasteride group provided numerically higher self-assessment scores than the placebo group for each parameter on the self-assessment questionnaire at 12 and 24 weeks. Only the 2.5-mg dutasteride and the finasteride groups at 24 weeks were consistently significantly greater than the placebo group for all parameters on the questionnaire (P < .05) (Table IV).
Table IV.
Percentage of men with improvement in scalp hair after 24 weeks according to answers to a self-assessment questionnaire
Dutasteride (mg)
Placebo 0.05 0.1 0.5 2.5 Finasteride (5.0 mg)
Size of vertex spot 31 58 57 52 69 61
Hair loss on top of scalp 29 55 52 40 63 51
Bitemporal recession 16 28 27 18 31 39
Hair shedding 47 67 63 56 74 64
Hair quality 36 47 47 45 60 57
Overall satisfaction 42 58 57 56 72 61
Overall the finasteride user were more satisfied than the .5 dutasteride users, though marginally :shock:
Table IV.
Percentage of men with improvement in scalp hair after 24 weeks according to answers to a self-assessment questionnaire
Dutasteride (mg)
Placebo 0.05 0.1 0.5 2.5 Finasteride (5.0 mg)
Size of vertex spot 31 58 57 52 69 61
Hair loss on top of scalp 29 55 52 40 63 51
Bitemporal recession 16 28 27 18 31 39
Hair shedding 47 67 63 56 74 64
Hair quality 36 47 47 45 60 57
Overall satisfaction 42 58 57 56 72 61
me thinks there is a very good reason why they decided to scrap the idea of marketing dutasteride for hairloss
the study
http://www.forhair.com/hairtransplant/about1099.html
dutasteride is much more powerful, but the outcome is underwhelming compared to finasteride.
point is, it is unjustified to suggest he moves on to dutasteride.