hedgehog_info
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Anybody understand this (Phorbol Esters and DHT) relationship. I have found a few articles but some ideas seem to be conflicting.
Phorbol ester causes ligand-independent activation of the androgen receptor
http://www.blackwell-synergy.com/doi/pd ... ookieSet=1
Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.
http://www.ncbi.nlm.nih.gov/entrez/quer ... get=_blank
Yes the Hh pathway is implicated in a wide variety of cancers. Pancreatic, Lung, BCC, Brain, Prostate and Breast to name a few big ones. Genentech just started Phase I clinical trials with a systemic Hh inhibitorWhat kind of cancer?