OrganTech Back in the News-Undiscovered Cell Type Neded to Regenerate Hair Follicles in Vivo

[Trichosan]

https://longevity.technology/news/japanese-startup-makes-hair-follicle-regeneration-breakthrough/

Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system - PubMed

Organ morphogenesis is essential for not only integrated organ functions in the body but also the determination of adult-tissue stem cells and their niche. Only hair follicle organs can cyclically regenerate in the variable bulbous germinative region as a form of programmed organ regeneration in...

pubmed.ncbi.nlm.nih.gov

 

[Ĺawton]

https://longevity.technology/news/japanese-startup-makes-hair-follicle-regeneration-breakthrough/

Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system - PubMed

Organ morphogenesis is essential for not only integrated organ functions in the body but also the determination of adult-tissue stem cells and their niche. Only hair follicle organs can cyclically regenerate in the variable bulbous germinative region as a form of programmed organ regeneration in...

pubmed.ncbi.nlm.nih.gov

I think the main issue with all this inserting stem cells stuff is that the scalp environment with most people will really limit what effects it can have. They will likely start struggling for the same reason their follicles are already degraded big time - because inflammation and the bodies response to that with DHT and IL-6 and all the other stuff that destroys the environment over time. I guess a few people it might have a real nice affect - probably the same ones that the environment is still good enough to allow minoxidil etc to have a nice effect on them.

 

[Jakejr]

Valid point for most of these laboratory experiments. But we have to start research somewhere.. The problem is males have 24/7 DHT damage.. How do we regrow hair in a damaging environment…The approach are to somehow supercharge hair growth hoping the plusses outweigh the negatives.. In this case it’s to regenerate completely new follicles.. But like a transplant DHT will start degrading them..

 

[Armando Jose]

Injecting stem cells into balding areas has been attempted many times, so why are there no publications? Because they haven't yielded results, and perhaps it's due to what Lawton pointed out: the environment is very degraded. Just think of the number of bald scientists and the laboratories that exist.
Altought "That's where the third cell type comes in, a helper tissue known as an accessory mesenchymal cell that provides scaffolding and structure, particularly around the follicle's 'bulge' and as part of a covering called the dermal sheath." They have a long travel till make a pilosebaceous unit, including sebaceous gland to make a miracle

 

[Ĺawton]

Valid point for most of these laboratory experiments. But we have to start research somewhere.. The problem is males have 24/7 DHT damage.. How do we regrow hair in a damaging environment…The approach are to somehow supercharge hair growth hoping the plusses outweigh the negatives.. In this case it’s to regenerate completely new follicles.. But like a transplant DHT will start degrading them..

Yep and unlike a transplant there isnt a good environment being imported in that will usually last some years before degrading a lot on some people. My opion is working on cleaning up the environmènt (fibrotic skin etc) and then an approach like PP405 or the fatty acid stuff to charge up the existing stem cells may be the better approach overall than inserting new stem cells. I do wonder if in some frontal balding though whether the body is resistant to restoring a decent hairline though so maybe this approach could work better there than the vertex area. It seems to me in some people after a certain amount of years the body starts treating the former hairline area as if its part of the forehead now and wont try to restore it.

 

[Ĺawton]

Injecting stem cells into balding areas has been attempted many times, so why are there no publications? Because they haven't yielded results, and perhaps it's due to what Lawton pointed out: the environment is very degraded. Just think of the number of bald scientists and the laboratories that exist.
Altought "That's where the third cell type comes in, a helper tissue known as an accessory mesenchymal cell that provides scaffolding and structure, particularly around the follicle's 'bulge' and as part of a covering called the dermal sheath." They have a long travel till make a pilosebaceous unit, including sebaceous gland to make a miracle

What is your view on the stuff that charges the follicle stem cells? PP405 and the fatty acid stuff. The fatty acid stuff if it keeps up on me being delivered with DMSO looks to be a mini miracle so far (I dont use finasteride or minoxidil) but I did work on cleaning the environment up for a long time before I started using that. My thinking is a pretty bad environment would definitely reduce the effects some but a few people might still get pretty big results.

 

[Armando Jose]

What is your view on the stuff that charges the follicle stem cells? PP405 and the fatty acid stuff. The fatty acid stuff if it keeps up on me being delivered with DMSO looks to be a mini miracle so far (I dont use finasteride or minoxidil) but I did work on cleaning the environment up for a long time before I started using that. My thinking is a pretty bad environment would definitely reduce the effects some but a few people might still get pretty big results.

I think that sebaceous gland is vital for a healthy hair. There is no hair without an associated sebaceous gland. Another issue is the possible use of stem cells when hair is transplanted. Respect cleaning issue it is important eliminate hardened sebum around hair.