Oral Setipiprant = Less Acne And Clearer Skin?

[westonci]

Anyone else notice this?

Started doing 200mg oral for two weeks now in the morning and I noticed my skin is way less oily as i naturally have very oily skin and haven't noticed any acne in a while which is unusual for me.

I know that the when hair miniaturizes from androgens the sebaceous gland secretes more sebum, thats why people notice oil scalp when going bald.

Could PGD2 be causing sebaceous gland hyperactivity and hence blocking it reduces acne?

 

[resu]

Maybe, Cosmo claims that Breezula (aka CB) also reduces PGD2 but it's an Anti-Androgen while Seti is not.

 

[Agent]

Where to get oral Seti and did you notice any difference regarding your hair loss?

 

[Afro_Vacancy]

Anyone else notice this?

Started doing 200mg oral for two weeks now in the morning and I noticed my skin is way less oily as i naturally have very oily skin and haven't noticed any acne in a while which is unusual for me.

I know that the when hair miniaturizes from androgens the sebaceous gland secretes more sebum, thats why people notice oil scalp when going bald.

Could PGD2 be causing sebaceous gland hyperactivity and hence blocking it reduces acne?

Why did you switch from topical to oral?

 

[hilbert]

Anyone eltotice this?

Started doing 200mg oral for two weeks now in the morning and I noticed my skin is way less oily as i naturally have very oily skin and haven't noticed any acne in a while which is unusual for me.

I know that the when hair miniaturizes from androgens the sebaceous gland secretes more sebum, thats why people notice oil scalp when going bald.

Could PGD2 be causing sebaceous gland hyperactivity and hence blocking it reduces acne?

not here, still sebum with oral seti and cb (and finasteride, in the past). the only oral stuff that kills my sebum is biotin 20mg ed.

 

[Folliman]

All anti-androgens should reduce pgd2 because androgens up-regulate it

 

[WMQ]

the only oral stuff that kills my sebum is biotin 20mg ed.

WTF?

How?

 

[hilbert]

WTF?

How?

how what?
btw, not even finasteride helped with my sebum (according to the theory of 5ar1).
Yes, what helps me is biotin 10/20mg and my usual topical with proge 1% and 17-alpha-estradiol 0,05%.

 

[Cody1212]

So no one has an answer on where to buy seti?

 

[Afro_Vacancy]

So no one has an answer on where to buy seti?

Wetonci can hook you up with group buys, or you can contact thekaneshop.

 

[Cody1212]

K I'll try writing Kane he just doesn't have seti listed on his site, it's anageninc.com right? Thanks David

 

[Afro_Vacancy]

K I'll try writing Kane he just doesn't have seti listed on his site, it's anageninc.com right? Thanks David

He doesn't list it, you have to contact him and ask privately.

Last I checked it was $12/gram, so an effective treatment was unlikely for middle class people.

If good seti reports emerge, I'll add a topical seti microdose to my regimen.

 

[WMQ]

how what?
btw, not even finasteride helped with my sebum (according to the theory of 5ar1).
Yes, what helps me is biotin 10/20mg and my usual topical with proge 1% and 17-alpha-estradiol 0,05%.

But I thought people get acnes from biotin?
Any idea how it reduced your sebum?

 

[hilbert]

But I thought people get acnes from biotin?
Any idea how it reduced your sebum?

no idea, never had acne. Actually 20mg is too much, 10mg is ok.
well, biotin is meant to reduce sebum, afaik.

 

[Swoop]

btw, not even finasteride helped with my sebum (according to the theory of 5ar1).

Inhibition of 1mg finasteride towards 5ar1 is negligible and dose dependent in the 1mg-100mg range according to this pharmacokinetic analysis: https://www.jstage.jst.go.jp/article/dmpk/25/2/25_2_208/_pdf

Finasteride has way stronger selectivity towards 5ar2.