For the purposes of hair growth it likely doesn’t matter. The short half life of minoxidil means it can be dosed up to 3x/day, but this would be more purposeful for the treatment of hypertension. I think in those who may experience orthostatic lightheadedness from the anti-hypertensive effect of minoxidil it may be be helpful to break up dosing into twice a day so that you still get the same cumulative dose while hopefully mitigating sides.