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Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice
Wenqing Li,1,† Jing Yang,1,† Jingbo Cai,1 Hongyu Wang,1 Haishan Tian,2 Jian Huang,1 Weidong Qiang,1 Linbo Zhang,1 Haiyan Li,1,* Xiaokun Li,2,* and Chao Jiang2,3,*
Abstract :
"Fibroblast growth factor 10 (FGF-10), also referred to as keratinocyte growth factor 2 (KGF-2), is a 24 kDa member of the fibroblast growth factor family and is composed of 208 amino acids [1]. Recombinant human FGF-10 (rhFGF-10) can enhance the proliferation of epidermal cells, and thereby promote the healing of injured skin [2]. It is frequently used to treat patients with mechanical injuries, burns and scalds of the skin, and it reduces scarring after healing [3]. Meanwhile, FGF-10 is necessary for hair growth, and may induce hair growth through activation of fibroblast growth factor receptor 2 [4], and also activation of the β-catenin and sonic hedgehog signaling pathways [5]."
Full Text :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666858/
Wenqing Li,1,† Jing Yang,1,† Jingbo Cai,1 Hongyu Wang,1 Haishan Tian,2 Jian Huang,1 Weidong Qiang,1 Linbo Zhang,1 Haiyan Li,1,* Xiaokun Li,2,* and Chao Jiang2,3,*
Abstract :
"Fibroblast growth factor 10 (FGF-10), also referred to as keratinocyte growth factor 2 (KGF-2), is a 24 kDa member of the fibroblast growth factor family and is composed of 208 amino acids [1]. Recombinant human FGF-10 (rhFGF-10) can enhance the proliferation of epidermal cells, and thereby promote the healing of injured skin [2]. It is frequently used to treat patients with mechanical injuries, burns and scalds of the skin, and it reduces scarring after healing [3]. Meanwhile, FGF-10 is necessary for hair growth, and may induce hair growth through activation of fibroblast growth factor receptor 2 [4], and also activation of the β-catenin and sonic hedgehog signaling pathways [5]."
Full Text :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666858/