Hey guys,
Long time lurker here, currently on the big 3 and having trouble maintaining. I've been thinking a lot about PDG2 and how it works along with our understanding of DHT and its effects on follicles, but I would like to start a discussion in case anyone has information to contribute.
After reading up on OC, PGD2 and its role in hair cycle signaling, it is clear that it certainly is part of the puzzle. The problem is that we don't have many instances of members reporting their usage of OC over time, with or without pictures.
While most people on OC have experienced a halt in shedding, they have not noticed any regrowth... The question is: While blocking PDG2 receptors with OC slows or halts shedding, is the follicle still being effected/malnourished by DHT? In other words, while the hair may not be falling out as frequently, is it continuing to weaken over time? If one were to stop OC and thus revert back to their excessive shedding, would the new hairs grow in fine and miniaturized due to the continued effects of DHT while on OC?
We know that PDG2 is downstream of DHT, so do we think that PDG2 is simply the cause of shedding, while DHT is the cause of miniaturization? (i.e. they work together as a whole function)
If this is the case, wouldn't it be best to combine OC + RU? (OC to stop shedding and RU to reduce the effects of DHT on the follicles). It appears that most combine OC + minoxidil, and while the desired result is the same (stability and regrowth), this is quite different than blocking the DHT receptors using RU..
Thoughts are welcome.
Long time lurker here, currently on the big 3 and having trouble maintaining. I've been thinking a lot about PDG2 and how it works along with our understanding of DHT and its effects on follicles, but I would like to start a discussion in case anyone has information to contribute.
After reading up on OC, PGD2 and its role in hair cycle signaling, it is clear that it certainly is part of the puzzle. The problem is that we don't have many instances of members reporting their usage of OC over time, with or without pictures.
While most people on OC have experienced a halt in shedding, they have not noticed any regrowth... The question is: While blocking PDG2 receptors with OC slows or halts shedding, is the follicle still being effected/malnourished by DHT? In other words, while the hair may not be falling out as frequently, is it continuing to weaken over time? If one were to stop OC and thus revert back to their excessive shedding, would the new hairs grow in fine and miniaturized due to the continued effects of DHT while on OC?
We know that PDG2 is downstream of DHT, so do we think that PDG2 is simply the cause of shedding, while DHT is the cause of miniaturization? (i.e. they work together as a whole function)
If this is the case, wouldn't it be best to combine OC + RU? (OC to stop shedding and RU to reduce the effects of DHT on the follicles). It appears that most combine OC + minoxidil, and while the desired result is the same (stability and regrowth), this is quite different than blocking the DHT receptors using RU..
Thoughts are welcome.