Novartis' Asthma Drug Fails In Phase 3 ! f*** f*** f*** !!!!!!

[jamesbooker1975]

https://www.fiercebiotech.com/biote...e-3-raising-doubts-about-gossamer-s-prospects

Fevipiprant is down !!!!!!!!!!
We are doomed .

Every little promising treatment, or at least with some hope, fall dawn .
Last off level drugs that was used for us ( Dutasteride ) hitted the market 17 years ago !!!!! and if we go to a approve med for Androgenetic Alopecia, that is Propecia, 22 years ago !!!!!

 

[whatevr]

Fails for Asthma, anyway. I don't understand though - is DP2 antagonism guaranteed to help that condition, meaning, if a drug doesn't work, then it is not a good DP2 antagonist?

Or it's possible that it does antagonize the receptor, just that DP2 antagonism in itself, even if done successfully, doesn't improve the condition? I doubt asthma hinges upon a single receptor, usually it's more complex than that.

 

[jamesbooker1975]

Fails for Asthma, anyway. I don't understand though - is DP2 antagonism guaranteed to help that condition, meaning, if a drug doesn't work, then it is not a good DP2 antagonist?

Or it's possible that it does antagonize the receptor, just that DP2 antagonism in itself, even if done successfully, doesn't improve the condition? I doubt asthma hinges upon a single receptor, usually it's more complex than that.

They talked about the dose . Anyway, for now , it look like the theory of DP2 don't works . Cool in papers, but not in real life.
Not optimist at all with this . They are doing another 2 phase 3 , but, look like will take forever , if , it it works.

 

[NilesCrane]

That’s gg

 

[d3nt3dsh0v3l]

Darn, I was looking forward to people trying a mixture DP2 antagonists, minoxidil, and microneedling - the poor man's Cotsarelis routine. Currently these experimental drugs are too costly to use in a daily routine as private lab synthesis is the only means of acquiring them.

 

[disfiguredyoungman]

Never had much faith in the product to be quite honest, fam.