Nizoral shampoo

[Jay Tee]

Can someone please educate me on this product? My doctor prescribed me 1 bottle of this after my recent hair transplant, and I'm using it every few days along with Tricomin shampoo and conditioner. But it seems like there are people here who use Nizoral as part of a regular regiment and not just after having a hair transplant. Is Nizoral a product that should be used constantly (like Minoxodil or Propecia) or is it just for a temporary period?

Also, if it is a good product to keep in use, is there any way to buy it without a prescription?

 

[juststarting]

Can someone please educate me on this product? My doctor prescribed me 1 bottle of this after my recent hair transplant, and I'm using it every few days along with Tricomin shampoo and conditioner. But it seems like there are people here who use Nizoral as part of a regular regiment and not just after having a hair transplant. Is Nizoral a product that should be used constantly (like Minoxodil or Propecia) or is it just for a temporary period?

Also, if it is a good product to keep in use, is there any way to buy it without a prescription?

Don't be shy. SEARCH is your FRIEND!

 

[Jay Tee]

Not shy just lazy. Plus I'd rather here it from someone who has experienced the product instead of reading an article.

 

[juststarting]

Not shy just lazy. Plus I'd rather here it from someone who has experienced the product instead of reading an article.

Well no help from me. There are only like 100+ posts about nizoral answering your questions. Good luck.

 

[ix]

http://www.counterhl.net/images/posting.swf

the link above will answer your question

 

[Jay Tee]

Not shy just lazy. Plus I'd rather here it from someone who has experienced the product instead of reading an article.

Well no help from me. There are only like 100+ posts about nizoral answering your questions. Good luck.

Thanks for clearing that up and proving how worthless you are at the same time.

Thanks for the link, IX.

 

[ix]

Thanks for the link, IX.

i take it you posted that before checking the link.. seriously though. red rose posted some info in the regular shampoo thread about nizoral..check what he says about it or pm him. he seems to know a lot of info about nizoral. personally i don't see anything special about nizoral compared to most other shampoos..click below

http://www.hairlosstalk.com/discussions/viewtopic.php?t=14829

 

[juststarting]

[quote="Jay Tee":66d45]Not shy just lazy. Plus I'd rather here it from someone who has experienced the product instead of reading an article.

Well no help from me. There are only like 100+ posts about nizoral answering your questions. Good luck.

Thanks for clearing that up and proving how worthless you are at the same time.

Thanks for the link, IX.[/quote:66d45]


haha a**h**!

 

[Jay Tee]

Man you fucks are lazier than me (and that says a lot, trust me). All this back and forth sh*t just for one lousy link. Thanks, fellas. :lol:

 

[Guest]

what i don't understand is that everybody (and bryan in the first place) is calling ketoconazole an anti-inflammatory, while this is bullshit. It's just an anti-androgen: it blocks the AR and lowers 5AR.

 

[Bismarck]

what i don't understand is that everybody (and bryan in the first place) is calling ketoconazole an anti-inflammatory, while this is bullshit. It's just an anti-androgen: it blocks the AR and lowers 5AR.

But it is sold for its anti-fungal properties and therfore has an indirect anti-inflammatory effect.

 

[Guest]

so you're saying that because it's SOLD as an anti-fungal, it has an anti-inflammatory effect?? That's strange logic

There is no evidence at all that the removal of fungals results in less inflammation. nizoral being an anti-inflammatory is a very unlikely theory. Everything indicates that's just an anti-androgen.

 

[The Gardener]

so you're saying that because it's SOLD as an anti-fungal, it has an anti-inflammatory effect?? That's strange logic

There is no evidence at all that the removal of fungals results in less inflammation. nizoral being an anti-inflammatory is a very unlikely theory. Everything indicates that's just an anti-androgen.

You have very bad information.

In fact, it's just plain wrong.

Naturally occuring fungi on the scalp can, for some people even WITHOUT male pattern baldness, cause inflammation. Have you ever heard of seborrheic dermatitis? Well, to make a long story short, it is inflammation of the scalp and anti-fungals such as T/Gel and Nizoral are the most commonly prescribed treatments to counter it.

The reason why anti-fungals such as T/Gel and Nizoral are good for people with male pattern baldness is because this natural tendency for fungus to cause irritation is exacerbated by the immune response that male pattern baldness creates. The irritation caused by male pattern baldness and the irritation caused by fungus have a synergistic effect which can exponentially accelerate hairloss. Keeping fungus in check helps keep the body's immune response tempered, which in turn mediates the body's immune response to the DHT.

Nizoral's anti-androgenetic properties are, in effect, just icing on the cake. An additional slight benefit that helps people facing androgenetic alopecia.

In your posting above, you make the following statement:

nizoral being an anti-inflammatory is a very unlikely theory. Everything indicates that's just an anti-androgen.

If what you claim is true, then why has the FDA approved Nizoral as an anti-fungal and anti-inflammatory, but has NOT approved it as an anti-androgen? If you think you know better, then perhaps you should be working for the FDA?

 

[Guest]

You have very bad information. In fact, it's just plain wrong.

Naturally occuring fungi on the scalp can, for some people even WITHOUT male pattern baldness, cause inflammation. Have you ever heard of seborrheic dermatitis? Well, to make a long story short, it is inflammation of the scalp and anti-fungals such as T/Gel and Nizoral are the most commonly prescribed treatments to counter it.

The reason why anti-fungals such as T/Gel and Nizoral are good for people with male pattern baldness is because this natural tendency for fungus to cause irritation is exacerbated by the immune response that male pattern baldness creates. The irritation caused by male pattern baldness and the irritation caused by fungus have a synergistic effect which can exponentially accelerate hairloss. Keeping fungus in check helps keep the body's immune response tempered, which in turn mediates the body's immune response to the DHT.

Nizoral's anti-androgenetic properties are, in effect, just icing on the cake. An additional slight benefit that helps people facing androgenetic alopecia.

I wonder... are you just repeating all information other people are telling you, or are you really checking it yourself?

if you would have been checking it yourself, you would conclude otherwise. It's not the anti-androgen effects that's the icing on the cake. It's the anti-fungal properties that's subordinate to the anti-androgen properties.

Seborrheic dermatitis is caused by a total different kind of inflammation than the kind that causes male pattern baldness. In fact, there's enough reason to doubt the whole role of inflammation in Androgenetic Alopecia, as there is no studie proving its excistance firmly.

But suppose there is inflammation involved in male pattern baldness, then it's of a total different kind than the dermatitis-inflammation. If it would be the same, than all the corticosteroids (like hydrocortisone, betamethasone) would work in fighting Androgenetic Alopecia. In fact, they do NOT.

And if killing fungals would help in fighting Androgenetic Alopecia, then all other antimycotica and anti-fungals (like griseofulvine) should work. In fact, they do NOT.

So there's all reason to believe that the only reason ketoconazole works in fighting Androgenetic Alopecia, is because of it's anti-androgen effects.

 

[Guest]

If what you claim is true, then why has the FDA approved Nizoral as an anti-fungal and anti-inflammatory, but has NOT approved it as an anti-androgen? If you think you know better, then perhaps you should be working for the FDA?

I'm not saying that ketoconazole has no anti-fungal effects. In fact, it are precise the anti-fungal properties what makes it effective against seborrhoec dermatitis. But against Androgenetic Alopecia, it are the anti-androgen properties that makes it effective.

 

[The Gardener]

Wrong again.

Why would the FDA approve the use of anti fungals, namely T/Gel and Nizoral, as treatments for seborrheic dermatitis if fungus were not the cause of seb derm symptoms?

Nizoral is an anti-fungal, period. That is what it was marketed as, that is what it was tested to be, and that is what the FDA allows Nizoral to be sold as.

The FDA has not approved the marketing nor sale of Nizoral as an anti-androgen.

Still waiting for your proof otherwise... it's the FDA versus whatever you have to cite here. And, I want some medical proof, not just your personal hypotheses.

EDIT: After posting the reply above, I just saw that additional post right above that you made where you backtracked on the initial statement you made. Good decision.

Your post right above mine, this one, asks a much more relevant question that might be worthy of some debate.

Cheers, Gard.

 

[Bismarck]

But suppose there is inflammation involved in male pattern baldness, then it's of a total different kind than the dermatitis-inflammation. If it would be the same, than all the corticosteroids (like hydrocortisone, betamethasone) would work in fighting Androgenetic Alopecia. In fact, they do NOT.

Immunsupressants do work for male pattern baldness !

 

[Guest]

Immunsupressants do work for male pattern baldness !

The only inmmunsupressant that works for male pattern baldness is cyclosporin, but that medicine is known to have anti-androgen effects as well.

Still waiting for your proof otherwise... it's the FDA versus whatever you have to cite here. And, I want some medical proof, not just your personal hypotheses.

The story that keto works because of it's anti-inflammatory effects, is a myth brought into the world by Cauwenbergh et al, the guys who did the big keto-studies. Perez, one of my favourite dermatologists, wrote about it:

Although the effects of ketoconazole on 5a-R have been documented, the authors of the study concluded that the benefits were attributed to its effects on fungal scalp infections in genetically predisposed individuals. They argued that Androgenetic Alopecia has a multifactorial pathogenesis with an inflammatory reaction caused by a Malassezia fungal infection. It was concluded that ketoconazole was therapeutic by reducing inflammation through its anti-inflammatory properties and by clearing the adjacent fungal infection. Exploration of the inflammatory aspect of Androgenetic Alopecia was in great part based on the results of a biopsy study by Jaworsky et al. [27], showing that Androgenetic Alopecia patients had signs of T-cell infiltration of follicular stem cell epithelium. However, limited conclusions should be drawn from the Jaworsky study because it only included 4 subjectsand only 3 of them were men.

And further:

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of Androgenetic Alopecia is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5a-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5a-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

Source: Perez: "Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men" (2003)

EDIT: After posting the reply above, I just saw that additional post right above that you made where you backtracked on the initial statement you made. Good decision.

I'm not backtracking at all, I said the same thing all the time: it's NOT the anti-fungal properties of ketoconazole that makes it effective against male pattern baldness!

 

[Bismarck]

Prolly a good idea to note that Androgenetic Alopecia is an inflammatory process.

 

[Guest]

Prolly a good idea to note that Androgenetic Alopecia is an inflammatory process.

as I said before: there is no clear evidence for that statement.