Dave001
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Nothing terribly special. I haven't posted in ages, so here's an icebreaker.
This last one isn't very recent at all, but it's probably the more interesting as some of you are using or have used niacin derivatives (possibly without knowing it).
(Sponsored by Starbucks...)Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro.
Int J Dermatol. 2007 Jan;46(1):27-35.
Fischer, TW; Hipler, UC; Elsner, P
Department of Dermatology and Allergology, Friedrich-Schiller-University, Jena, Germany. tobias.fischer@derma.uni-jena.de
BACKGROUND: Androgenetic alopecia (Androgenetic Alopecia) is a common problem in men of all ages, affecting approximately 50% at 50 years of age. The underlying cause is an androgen-dependent miniaturization of genetically predetermined hair follicles. Here, the hair organ culture model was used to investigate the effects of testosterone and caffeine; the latter being a promising candidate for hair growth stimulation. METHODS: Hair follicles from 14 biopsies, taken from the vertex areas from male Androgenetic Alopecia patients, were cultivated for 120-192 h in vitro with normal William's E medium (control) or William's E medium containing different concentrations of testosterone and/or caffeine. Hair shaft elongation was measured daily and at the end of cultivation, cryosections of follicles were stained with Ki-67 to evaluate the degree and localization of keratinocyte proliferation. RESULTS: Significant growth suppression was found in hair follicles treated with 5 microg/ml testosterone. This was counteracted by caffeine in concentrations of 0.001% and 0.005%. Moreover, caffeine alone led to a significant stimulation of hair follicle growth. These results were confirmed immunohistochemically by Ki-67 staining. CONCLUSIONS: Androgen-dependent growth inhibition of ex vivo hair follicles from patients suffering from Androgenetic Alopecia was present in the human hair organ culture model, a constellation which may serve for future studies to screen new substances against androgen-dependent hair loss. Caffeine was identified as a stimulator of human hair growth in vitro; a fact which may have important clinical impact in the management of Androgenetic Alopecia.
PMID: 17214716
The additive effects of minoxidil and retinol on human hair growth in vitro.
Biol Pharm Bull. 2007 Jan;30(1):21-6.
Yoo, Hyeon Gyeong; Chang, In-Young; Pyo, Hyun Keol; Kang, Yong Jung; Lee, Seung Ho; Kwon, Oh Sang; Cho, Kwang Hyun; Eun, Hee Chul; Kim, Kyu Han
Department of Dermatology, Seoul National University College of Medicine, Korea.
Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (Androgenetic Alopecia), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.
PMID: 17202653
This last one isn't very recent at all, but it's probably the more interesting as some of you are using or have used niacin derivatives (possibly without knowing it).
A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.
J Cosmet Dermatol. 2005 Dec;4(4):258-61.
Draelos, Zoe Diana; Jacobson, Elaine L; Kim, Hyuntae; Kim, Moonsun; Jacobson, Myron K
Department of Dermatology, Wake Forest University School of Medicine, NC.
Background Female pattern alopecia is a common dermatologic condition that manifests after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application. Aims This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia. Patients/methods Sixty female subjects with Ludwig types I-III female pattern hair loss were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application. Results The niacin derivatives demonstrated a statistically significant increase in hair fullness (P = 0.04 compared to the placebo). Conclusion Whereas evaluation of hair growth in women is challenging, this 6-month pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.
PMID: 17168873