G
Guest
Guest
Got a new Ketoconazole 2% Shampoo today: "Ketopine"
Got my mum (bless her old soul) to tell the doctor she had an itchy scalp and that she had used Nizoral before and it had worked great so he wrote her a prescription for this stuff.
So free Ketoconazole shampoo for me, the tax paying British public get shafted by my simple yet cunning plan and you lot get some new info on Ketoconazole, it's all worked out good.
Haaa,,,muhaaaaamuhamuhaaaHAHAHAHAHAHAHAHAHA
Ty
_______________________________________________
Ketopine 2% Shampoo
2% w/w ketoconazole shampoo
AFT Pharmaceuticals
Presentation
A clear, pink coloured, viscous liquid with a fragrant smell.
Uses
Actions
Microbiology: KETOPINE is a broad-spectrum synthetic antifungal agent which inhibits the growth of the following common dermatophytes and yeasts by altering the permeability of the cell membrane. Dermatophytes: Trichophyton rubrum, T mentagrophytes, T tonsurans, Microsporum canis, M audouini, M gypseum and Epidermophyton floccosum. Yeasts: Candida albicans, C tropicalis, Pityrosporum ovale (Malassezia ovale) and P orbiculare (M furfur). Development of resistance to ketconazole has not been reported. In vitro studies suggest that ketoconazole impairs the synthesis of ergosterol, which is a vital component of fungal cell membranes. The mechanism of the therapeutic effect in seborrhoeic dermatitis and dandruff has not been established. It is postulated that the therapeutic effect of ketoconazole in dandruff may be due to the reduction in number of P ovale, but this has not been proven.
Pharmacokinetics
Absorption of ketoconazole from shampoo formulations is generally minimal.
Toxicology. Clinical studies showed that the irritancy potential of ketoconazole 2% shampoo was significantly less than that of selenium sulfide 2.5% shampoo.
Human volunteer studies on the potential to cause sensitisation, phototoxicity and photoallergy showed no contact sensitisation of the delayed hypersensitivity type, no phototoxicity and no photoallergenic potential due to ketoconazole 2% shampoo.
Indications
Topical treatment of severe seborrhoeic dermatitis and severe dandruff of the scalp in adults.
For both conditions, KETOPINE 2% Shampoo provides only temporary relief during the period of its use. Both conditions relapse soon after discontinuation of treatment. The relapse rate for seborrhoeic dermatitis is not known, but for dandruff it is high within a short time after cessation of treatment.
Dosage and Administration
KETOPINE 2% Shampoo should be applied to the wet scalp, worked into a lather and left on for three to five minutes before rinsing thoroughly with water. The use of unnecessarily large quantities of KETOPINE 2% Shampoo during treatment should be avoided.
The duration of treatment should be limited to twice weekly for no longer than four weeks at any one time. An interval of at least four weeks should be allowed between consecutive courses.
Contraindications
Hypersensitivity to any ingredient.
Warnings and Precautions
Irritation may occur when KETOPINE 2% Shampoo is used immediately after prolonged treatment with topical corticosteroids on the same area. Therefore, it is recommended to wait about two weeks after stopping treatment with topical corticosteroids before using KETOPINE 2% Shampoo.
If a reaction suggesting sensitivity or chemical irritation should occur, use of KETOPINE 2% Shampoo should be discontinued.
Seborrhoeic dermatitis and dandruff are often associated with increased hair shredding, and this has also been reported, although rarely, with the use of KETOPINE 2% shampoo.
Safety of use beyond four weeks has not been adequately established.
Avoid contact with the eyes. If the shampoo should get into the eyes, they should be bathed with cold water.
Use in Pregnancy
KETOPINE 2% shampoo does not produce detectable blood levels after topical application. However, due to the teratogenic nature of the active ingredient in rats when given orally, it should only be used in pregnant or lactating women if in the judgment of the treating doctor the expected benefits outweigh the potential risk.
Use in Lactation
See Use in pregnancy.
Adverse Effects
KETOPINE 2% shampoo is generally well tolerated. Reported adverse events included allergic reaction, itchy, irritated or greasy skin and scalp, rash and erythema. As with other shampoos, a local burning sensation, oiliness and dryness of the hair and scalp have also been reported. In rare instances, mainly in patients with chemically damaged hair or grey hair, a discolouration of the hair has been observed. One case of exfoliative dermatitis has been reported but its relationship to the use of the shampoo is uncertain.
Overdosage
Symptoms
Oral ingestion is usually followed by nausea and vomiting due to the detergent.
Treatment
In the event of accidental ingestion, only supportive measures should be employed. To avoid aspiration, neither emesis nor gastric lavage should be performed.
Pharmaceutical Precaution
Store below 25°C.
Package Quantities
100 ml bottles.
Further Information
Other ingredients of the shampoo are: Sodium laureth sulfate, disodium laureth sulfosuccinate, sodium chloride, citric acid monohydrate, benzyl alcohol, tetrasodium EDTA, quaternium-15, polyquaternium-7, dexpanthenol, laureth-2, sodium hydroxide, erythrosine (E127), perfume and purified water.
Got my mum (bless her old soul) to tell the doctor she had an itchy scalp and that she had used Nizoral before and it had worked great so he wrote her a prescription for this stuff.
So free Ketoconazole shampoo for me, the tax paying British public get shafted by my simple yet cunning plan and you lot get some new info on Ketoconazole, it's all worked out good.
Haaa,,,muhaaaaamuhamuhaaaHAHAHAHAHAHAHAHAHA
Ty
_______________________________________________
Ketopine 2% Shampoo
2% w/w ketoconazole shampoo
AFT Pharmaceuticals
Presentation
A clear, pink coloured, viscous liquid with a fragrant smell.
Uses
Actions
Microbiology: KETOPINE is a broad-spectrum synthetic antifungal agent which inhibits the growth of the following common dermatophytes and yeasts by altering the permeability of the cell membrane. Dermatophytes: Trichophyton rubrum, T mentagrophytes, T tonsurans, Microsporum canis, M audouini, M gypseum and Epidermophyton floccosum. Yeasts: Candida albicans, C tropicalis, Pityrosporum ovale (Malassezia ovale) and P orbiculare (M furfur). Development of resistance to ketconazole has not been reported. In vitro studies suggest that ketoconazole impairs the synthesis of ergosterol, which is a vital component of fungal cell membranes. The mechanism of the therapeutic effect in seborrhoeic dermatitis and dandruff has not been established. It is postulated that the therapeutic effect of ketoconazole in dandruff may be due to the reduction in number of P ovale, but this has not been proven.
Pharmacokinetics
Absorption of ketoconazole from shampoo formulations is generally minimal.
Toxicology. Clinical studies showed that the irritancy potential of ketoconazole 2% shampoo was significantly less than that of selenium sulfide 2.5% shampoo.
Human volunteer studies on the potential to cause sensitisation, phototoxicity and photoallergy showed no contact sensitisation of the delayed hypersensitivity type, no phototoxicity and no photoallergenic potential due to ketoconazole 2% shampoo.
Indications
Topical treatment of severe seborrhoeic dermatitis and severe dandruff of the scalp in adults.
For both conditions, KETOPINE 2% Shampoo provides only temporary relief during the period of its use. Both conditions relapse soon after discontinuation of treatment. The relapse rate for seborrhoeic dermatitis is not known, but for dandruff it is high within a short time after cessation of treatment.
Dosage and Administration
KETOPINE 2% Shampoo should be applied to the wet scalp, worked into a lather and left on for three to five minutes before rinsing thoroughly with water. The use of unnecessarily large quantities of KETOPINE 2% Shampoo during treatment should be avoided.
The duration of treatment should be limited to twice weekly for no longer than four weeks at any one time. An interval of at least four weeks should be allowed between consecutive courses.
Contraindications
Hypersensitivity to any ingredient.
Warnings and Precautions
Irritation may occur when KETOPINE 2% Shampoo is used immediately after prolonged treatment with topical corticosteroids on the same area. Therefore, it is recommended to wait about two weeks after stopping treatment with topical corticosteroids before using KETOPINE 2% Shampoo.
If a reaction suggesting sensitivity or chemical irritation should occur, use of KETOPINE 2% Shampoo should be discontinued.
Seborrhoeic dermatitis and dandruff are often associated with increased hair shredding, and this has also been reported, although rarely, with the use of KETOPINE 2% shampoo.
Safety of use beyond four weeks has not been adequately established.
Avoid contact with the eyes. If the shampoo should get into the eyes, they should be bathed with cold water.
Use in Pregnancy
KETOPINE 2% shampoo does not produce detectable blood levels after topical application. However, due to the teratogenic nature of the active ingredient in rats when given orally, it should only be used in pregnant or lactating women if in the judgment of the treating doctor the expected benefits outweigh the potential risk.
Use in Lactation
See Use in pregnancy.
Adverse Effects
KETOPINE 2% shampoo is generally well tolerated. Reported adverse events included allergic reaction, itchy, irritated or greasy skin and scalp, rash and erythema. As with other shampoos, a local burning sensation, oiliness and dryness of the hair and scalp have also been reported. In rare instances, mainly in patients with chemically damaged hair or grey hair, a discolouration of the hair has been observed. One case of exfoliative dermatitis has been reported but its relationship to the use of the shampoo is uncertain.
Overdosage
Symptoms
Oral ingestion is usually followed by nausea and vomiting due to the detergent.
Treatment
In the event of accidental ingestion, only supportive measures should be employed. To avoid aspiration, neither emesis nor gastric lavage should be performed.
Pharmaceutical Precaution
Store below 25°C.
Package Quantities
100 ml bottles.
Further Information
Other ingredients of the shampoo are: Sodium laureth sulfate, disodium laureth sulfosuccinate, sodium chloride, citric acid monohydrate, benzyl alcohol, tetrasodium EDTA, quaternium-15, polyquaternium-7, dexpanthenol, laureth-2, sodium hydroxide, erythrosine (E127), perfume and purified water.
