New FNS
- Thread starter viperfish
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n1kki6
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NS - Definition
FNS is a topically applied formula designed to treat hair loss.
FNS - The Concept
The idea for FNS for treating alopecia was conceived during the development of a treatment for chronic wounds. The rationale for this concept, proven reasonable, was to bypass the circulatory insufficiency that exists in and around the wound. This formula creates an optimal microenvironment and supplies the cells in the wound with the required means for growth. Indeed, within a relatively short period, the treatment resulted in complete healing of the wounds which previously failed to respond to months and even years of conventional treatments. An interesting phenomenon was observed during the treatment, the hair follicles around the wound were stimulated to synthesize the proteins needed for growth of new hair. The next step, i.e., testing the effects of formula on scalp hair growth was self-evident.
FNS - Composition
FNS is composed of three major components:
1. Non-steroidal anabolic hormone
2. Cell culture medium
3. Vehicle
These components and their role in stimulation, supply, and support contribute to the overall beneficial effects of FNS.
This in-situ tissue culture technology is implemented, with minor adaptations, into other medical applications.
Hair Growth - General
The process of hair growth involved many types of cells forming tissues which are organized into an organ called the hair follicle. The scalp hair growth cycle involves three phases. The growth phase associated with the active follicle (anagen) is followed by the regressive phase in which the follicle ceases to synthesize the keratin (catagen) and finally the hair falls off (telogen).
At any time, about 90% of the scalp hair is in the anagen phase. Anagen lasts for about two years during which the hair shaft continues to elongate. In a normal cycle, the regressive phase lasts about three months and thereafter the hair follicles re-enter the anagen phase of growth. However, in the process of balding an increased number of hair follicles revert to the regressive phase resulting in enhancement of hair loss. It is known that the cycle is affected by factors such as hormones, chemicals, emotions, etc. The most common type of balding is Androgenetic Alopecia (Male Pattern Baldness) that affects both men and women.
FNS - The Effect
The hypothesis was that FNS will activate the follicle to return to the anagen phase resulting in cessation of hair loss and induction of hair regrowth. The effects of the FNS components were tested on a number of experimental systems.
The following experiments indicate direct evidence of FNS action on hair:
1. A six-month, double blind, randomized, vehicle controlled study on young men suffering from androgenetic alopecia. Cessation of hair loss within three weeks was reported by most of the participants which was corroborated by a significant increase in hair counts of the treated group compared to the vehicle treated group. These findings were supported by an overall increase in subjective satisfaction with the treatment and by objective global evaluation of the FNS treated group.
2. In-vivo human hair organ culture. Growth at optimal rate of 0.3 mm/day for 10 days in the presence of FNS (without vehicle). In addition, restored pigmentation of hair was observed.
The following experiments provide indirect support for FNS biological activity.
1. Laser Doppler circulation measurements. Burn wounds treated with the tissue culture technology expressed increased circulation.
2. In-vivo cells proliferation. The in-situ tissue culture technology was found effective in accelerating wound healing. Although each of the components had some effects, the combination was significantly more effective. The process of wound healing involved the formation of vascular granulation tissue and keratinocytes proliferation.
3. Extended cell viability. Adipocytes viability in culture medium was maintained for three weeks compared to one week of the control.
To summarize:
FNS stimulates viable regressive follicles to re-enter the anagen phase as well as supporting the hair growth. It supplies nutrition to the cells in a direct mode and via induction of increased circulation and neovascularization. No side effects were reported or observed.
FNS - Why
Currently there are two main products that obtained FDA approval for marketing as a drug for treating alopecia. The first is Minoxidil marketed under the name Rogaineâ„¢ which was originally used for treating high blood pressure by induction of peripheral vasodilation; its daily application also produced side effects of growing new hair. It is now sold OTC (over the counter) but it has many side-effects.
The second product is marketed under the name Propeciaâ„¢ and it is allowed for use only on men. This product also produces side effects and therefore its use is limited.
FNS - The Source
FNS is one more product developed in the tissue regeneration unit at the Technion's school of medicine. The laboratory, headed by Prof. Ella Lindenbaum, a holder of a number of international patents, is involved in applied medical research and dedicated to the idea of developing medical commercial products.
An important aspect of the work in the laboratory is the continuous collaboration with colleagues in the clinical departments of the Faculty affiliated hospitals.
In addition, Prof. Lindenbaum is a scientific consultant to several incubator start up biotechnology companies and a consultant to Osmotics Corp.
FNS is a topically applied formula designed to treat hair loss.
FNS - The Concept
The idea for FNS for treating alopecia was conceived during the development of a treatment for chronic wounds. The rationale for this concept, proven reasonable, was to bypass the circulatory insufficiency that exists in and around the wound. This formula creates an optimal microenvironment and supplies the cells in the wound with the required means for growth. Indeed, within a relatively short period, the treatment resulted in complete healing of the wounds which previously failed to respond to months and even years of conventional treatments. An interesting phenomenon was observed during the treatment, the hair follicles around the wound were stimulated to synthesize the proteins needed for growth of new hair. The next step, i.e., testing the effects of formula on scalp hair growth was self-evident.
FNS - Composition
FNS is composed of three major components:
1. Non-steroidal anabolic hormone
2. Cell culture medium
3. Vehicle
These components and their role in stimulation, supply, and support contribute to the overall beneficial effects of FNS.
This in-situ tissue culture technology is implemented, with minor adaptations, into other medical applications.
Hair Growth - General
The process of hair growth involved many types of cells forming tissues which are organized into an organ called the hair follicle. The scalp hair growth cycle involves three phases. The growth phase associated with the active follicle (anagen) is followed by the regressive phase in which the follicle ceases to synthesize the keratin (catagen) and finally the hair falls off (telogen).
At any time, about 90% of the scalp hair is in the anagen phase. Anagen lasts for about two years during which the hair shaft continues to elongate. In a normal cycle, the regressive phase lasts about three months and thereafter the hair follicles re-enter the anagen phase of growth. However, in the process of balding an increased number of hair follicles revert to the regressive phase resulting in enhancement of hair loss. It is known that the cycle is affected by factors such as hormones, chemicals, emotions, etc. The most common type of balding is Androgenetic Alopecia (Male Pattern Baldness) that affects both men and women.
FNS - The Effect
The hypothesis was that FNS will activate the follicle to return to the anagen phase resulting in cessation of hair loss and induction of hair regrowth. The effects of the FNS components were tested on a number of experimental systems.
The following experiments indicate direct evidence of FNS action on hair:
1. A six-month, double blind, randomized, vehicle controlled study on young men suffering from androgenetic alopecia. Cessation of hair loss within three weeks was reported by most of the participants which was corroborated by a significant increase in hair counts of the treated group compared to the vehicle treated group. These findings were supported by an overall increase in subjective satisfaction with the treatment and by objective global evaluation of the FNS treated group.
2. In-vivo human hair organ culture. Growth at optimal rate of 0.3 mm/day for 10 days in the presence of FNS (without vehicle). In addition, restored pigmentation of hair was observed.
The following experiments provide indirect support for FNS biological activity.
1. Laser Doppler circulation measurements. Burn wounds treated with the tissue culture technology expressed increased circulation.
2. In-vivo cells proliferation. The in-situ tissue culture technology was found effective in accelerating wound healing. Although each of the components had some effects, the combination was significantly more effective. The process of wound healing involved the formation of vascular granulation tissue and keratinocytes proliferation.
3. Extended cell viability. Adipocytes viability in culture medium was maintained for three weeks compared to one week of the control.
To summarize:
FNS stimulates viable regressive follicles to re-enter the anagen phase as well as supporting the hair growth. It supplies nutrition to the cells in a direct mode and via induction of increased circulation and neovascularization. No side effects were reported or observed.
FNS - Why
Currently there are two main products that obtained FDA approval for marketing as a drug for treating alopecia. The first is Minoxidil marketed under the name Rogaineâ„¢ which was originally used for treating high blood pressure by induction of peripheral vasodilation; its daily application also produced side effects of growing new hair. It is now sold OTC (over the counter) but it has many side-effects.
The second product is marketed under the name Propeciaâ„¢ and it is allowed for use only on men. This product also produces side effects and therefore its use is limited.
FNS - The Source
FNS is one more product developed in the tissue regeneration unit at the Technion's school of medicine. The laboratory, headed by Prof. Ella Lindenbaum, a holder of a number of international patents, is involved in applied medical research and dedicated to the idea of developing medical commercial products.
An important aspect of the work in the laboratory is the continuous collaboration with colleagues in the clinical departments of the Faculty affiliated hospitals.
In addition, Prof. Lindenbaum is a scientific consultant to several incubator start up biotechnology companies and a consultant to Osmotics Corp.
viperfish
Senior Member
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The new FNS was supposed to be out this fall. It is supposed to be much improved over the older formula, which yeah was complete bullshit. I have recently heard of the new formula on other websites and was wondering if anyone had any news or new about this at this website. The old formula is found at http://www.osmotics.com.
A
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This thread belongs in the unproven section.
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