wookiewannabe said:
I have a question about androgen receptors and the hydraulic theory of baldness:
http://www.ehrs.org/conferenceabstracts ... sawaya.htm
All scalp biopsies from patients obtained 6 months after finasteride treatment revealed intense upregulation of AR expression in comparison to pre-treatment biopsies of the same patient, whereas ERs were not affected, indicating that AR is very sensitive to the affects of 5a-R type II suppression of DHT.
:freaked: :freaked: :freaked:
How does the hydraulic theory of baldness explain this upregulation of androgen receptors due to finasteride and what part do androgen receptors play in the hydraulic/androgenic balding scenario.
It is a good question, and the answer is simple.
My theory also requires that DHT is produced in the dermal tissue. I am suggesting that DHT evolved primarily to increase lymphatic drainage, and that is it's important role as a male hormone.
Any substance that has evolved to increase lymphatic drainage, would have to be largely produced in the outer tissue (the dermis).
Why? Because if such a substance was mainly introduced into lymph vessels towards the core of the body, the increased vessel pumping would restric flow from the outer tissues.
This back pressure effect is what happens in male pattern baldness according to my theory.
The area's of DHT production according to Merck are quote:
"Type I 5 alpha reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver. Type I 5 alpha reductase is responsible for approximately one third of circulating DHT.The type II 5 alpha reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two thirds of circulating DHT."
DHT production largely in the dermis (the biggest organ in the body), ensures an even effect on lymphatic pumping.
The upregulation process in follicles and other DHT producing structures, is natures way of trying to maintain DHT production.
But this dosen't have to mean the physical effect of DHT is designed to happen where it is produced!
Consider this?
If DHT is only going to be used where it is produced, why is there serum DHT?
This is very inefficient, and nature is not normaly so? Also, why is DHT being produced in the liver? What "direct" function is DHT doing there?
The only possible reason for DHT to be produced in the liver, is so it can be released into the circulation for some purpose.
S Foote.