Morning or Night?

[ripple-effect]

Should I switch to taking .5mg of Finasteride in the morning instead of @ night? I heard someone say it made a difference for them?

 

[hair today gone tomorrow]

it doesnt make a difference at all....hell, you could alternate between night and day and it still wouldnt make a difference. Its best to take it the same time everyday simply b/c its easier to remember that way.

 

[SkylineGTR]

yes the concentration stays in your system after you build it up so it doesn't matter what time of day you take it. as long as you take it daily.

 

[Guest]

yes the concentration stays in your system after you build it up so it doesn't matter what time of day you take it. as long as you take it daily.

Skyline. The half-life of the drug itself is 6 hours. So if you take 1mg than 12 hours later you'll have 0.25mg left. As we know 0.25mg is 90% as effective as 1mg.

Though I don't believe there is a "build-up" so to say since the half-life is stated as 6-hours. It's the fact that it takes 14 days for Type 1 5AR to regenerate and 30 days for the Type II 5AR enzyme.

 

[SkylineGTR]

Thank you for your question on finasteride. From RxList.com, there is
a good description of the pharmacokinetics of finasteride:
http://www.rxlist.com/cgi/generic3/propecia_cp.htm

From this reference, finasteride works primarily on the Type II
isozyme of the 5-alpha reductase. Here is a quote:
"In humans, the mechanism of action of finasteride is based on its
preferential inhibition of the Type II isozyme. Using native tissues
(scalp and prostate), in vitro binding studies examining the potential
of finasteride to inhibit either isozyme revealed a 100-fold
selectivity for the human Type II 5a-reductase over Type I isozyme
(IC50=500 and 4.2 nM for Type I and II, respectively). For both
isozymes, the inhibition by finasteride is accompanied by reduction of
the inhibitor to dihydrofinasteride and adduct formation with NADP+.
The turnover for the enzyme complex is slow ([half-life] approximately
30 days for the Type II enzyme complex and 14 days for the Type I
complex)."

This means, as one commentator stated, that the half-life of the
enzyme after long term exposure to finasteride is approximately 30
days.

http://answers.google.com/answers/threadview?id=483630

hence why people take it daily or EOD or weekly

There has to be a "build up" so to speak of resistance. not of the actual drug itself.