Minoxodil and Tolerance and increasing ineffectiveness....

[michael barry]

Hello guys,
I read on a site called male pattern baldness Research that minoxodil users develop "tolerance" to the drug and have to go to the 5% solution, where they will again effectively develop "tolerance" to it also. They claim tolerance happens within 12-18 months.


What was scary was that when one stops taking it, the shed is supposedly enormous and docs think its beyond just the new hairs that were coaxed to grow with its use, but other older hairs as well. They supposedly call this phenomena "minoxodil-dependent hair". Has anyone experienced this or heard of this?

Wonderin'------------------By the way the site prescribes one takes Finasteride, Folligen, Grape Seed extract, Nizoral, and a few other things that are recommended by HairLossTalk.com.

 

[Old Baldy]

Well studies show that minoxidil. does seem to plateau on average. However, that site you mentioned never seems to provide studies for much of the stuff recommended. I'm not sure about that site if you know what I mean!

Alot of doctors recommend minoxidil., yet that site says to stay away from it.

I mean, that site once said (somewhere - I can't find where they said that any more) that there was no Type II enzyme in the follicles! Plus they state aromatase (sp?) is a cause of male pattern baldness but I found out later that our non-balding, side hairs have alot of aromatase in them! (I would like to know how much aromatase women have in their follicles?)

Imagine my situation, I'm just starting to research male pattern baldness back in Sept., 2004 and I read all this info. about Type II being bad. Doctors, researchers, veteran posters, etc., all say Type II is bad. THEN, I go to that site and, I swear somewhere, they say Type II isn't in the follicles. RED flags go up and I just didn't pay much attention to them after that ridiculous position. THEN, I read other studies showing aromatase is in alot of non-balding follicles yet they say aromatase is heavily involved in balding. I was, and still am confused, about that one!

In any event, alot of their positions just don't seem to play out when you look at other medical studies.

 

[Guest]

minoxidil really is a massive commitment. You need to 100% sure that you want to apply it twice a day for a number of years. let alone the cost of getting it. urrghhhhh

 

[alfonso2501]

I developed Minoxidil tolerance about 8 years after I started using it! I then came across this website and started using XANDROX 15% in the morning along with 1/6 of fincar every day. It’s been less then a year later and it’s a whole lot better now!

Don’t let that site you came across sway you! You don’t develop tolerance within 12-18 months. You’ll see good results with in a year of using Minoxidil, just make sure you apply 2x every day.

 

[sam-]

Re: Minoxodil and Tolerance and increasing ineffectiveness..

What was scary was that when one stops taking it, the shed is supposedly enormous and docs think its beyond just the new hairs that were coaxed to grow with its use, but other older hairs as well.

:freaked:
Link to that site please....

 

[iamnaked]

f*** the scare stories. All I want is to keep my hair for a few more years before I'm older and wiser and everyone else is balder whereapon it will stop mattering so much. Anway, pricewise minoxidil only costs me £45 ~90 USD per year.

 

[Guest]

I am curious about this, but would there be any advantage to just SKIP a day or two of topical treatments? I've heard people say to "give the scalp a rest" but I'm thinking a little bit along different lines.

Your follicles might become accustomed to receiving a jolt of minoxidil, apple poly, peptides, etc. and might be accustomed to simply receiving them every 12 hours. Perhaps this process takes the one year in some but if took a day, or two, or three, every couple of months or simply did something to shake up the topical routine perhaps this could maximize effectiveness?

It's not really an apples-apples comparison but with weight lifting you will need to change your routine around every once in a while to get out of that plateau, and we have to cycle creatine supplementation as well. Spectral DNC says that any regrown hair will fall out within 2 months after quitting treatment so if we take a few days off every couple of months this shouldn't hurt us in that sense right? Just curious if this would help maximize effectiveness.

 

[joseph49853]

I've been using Retin-a and needling, and now caffeine, to keep ahead of the tolerance curve. I only have anecdotal evidence to report, but I've actually grown much healthier, thicker, fuller/more dense hair with needling/retin-a/minoxidil than on minoxidil alone. Increasing absorption, and decreasing application times/amounts, is definitely part of the solution, in my mind.

 

[hair_tomorrow]

I am curious about this, but would there be any advantage to just SKIP a day or two of topical treatments? I've heard people say to "give the scalp a rest" but I'm thinking a little bit along different lines.

. . . quote]

I forget his rationale, but Dr. Pickart suggests taking a weekend off topicals evey 2 weeks.

I don't really shedule time off from my topicals - but if I ever miss an application or A DAY HERE OR THERE (capslock, sorry), I don't sweat it.

 

[Guest]

I forget his rationale, but Dr. Pickart suggests taking a weekend off topicals evey 2 weeks.

I don't really shedule time off from my topicals - but if I ever miss an application or A DAY HERE OR THERE (capslock, sorry), I don't sweat it.

A weekend off only every 2 weeks?!?! Hmmmm, I'd like to hear the rationale for that. Even than I would think that your follicles might become accustomed to this regimented procedure of 2 weeks on and 2 days off. I would probably think that mixing it up a bit might be more effective but just a theory backed by no evidence

 

[holly]

Dr. Proctor also suggests on the fact sheet he provides with Prox-N, that after a year or so of 1-2 times daily application, one might be able to go to 3 times a week for maintenance. Perhaps, that is to mitigate tolerance.