Microdosing Topical Finasteride And Dutasteride (1/10000 Mg)

[Kevand]

Hi!
You can read about my experiments and past treatment here:
https://www.hairlosstalk.com/intera...t-free-anti-androgen-topical-solution.100824/

I just want to share that I have been ultra microdosing finasteride and dutasteride in ell-cranell vehicle each separately. In a concentration range of 1/100- 1/10 000mg / ml. Effect: I get tired to the extent I barely can't get up from my bed, pain in my joints, brain fog, back pain etc. I believe I get some sort of systemic reaction to both finasteride and dutasteride rather than being effects from dht-reduction, but I am unsure for comparison I also got increased libido at start, which I also got when i tried 0,25 mg finasteride for the first time. I have no stopped my topical microdosing experiment.

 

[Afro_Vacancy]

0.01 mg/day should have minimal effect. At that point it reduces DHT by around 15%.

One guy a while back reported limp dick from 0.03 mg a day. He stopped taking it.

 

[Kevand]

I believe I'm a very extreme outlier and very sensitive to anti-androgen, alpha inhib and maybe drugs overall. I have read most studies concerning finasteride dose-effect curves and I believe I have significant dht reduction at 0,01 mg/ ml topical which should translate to an even lower dose to match oral dose. But at 1/10 000 mg/ml topical I'm starting to doubt that it can have a dht reducing effect even tho i can correlate some symptoms with dht-reduction. I am perhaps 1 in a million.

 

[Afro_Vacancy]

How many ml are you applying?

 

[g.i joey]

I believe I'm a very extreme outlier and very sensitive to anti-androgen, alpha inhib and maybe drugs overall. I have read most studies concerning finasteride dose-effect curves and I believe I have significant dht reduction at 0,01 mg/ ml topical which should translate to an even lower dose to match oral dose. But at 1/10 000 mg/ml topical I'm starting to doubt that it can have a dht reducing effect even tho i can correlate some symptoms with dht-reduction. I am perhaps 1 in a million.

With a dose that small I can't help but think placebo is definitely at play

 

[Kevand]

1 ml.

How many ml are you applying?

 

[Kevand]

With a dose that small I can't help but think placebo is definitely at play

No placebo. Several times I stopped till it got better (maybe 3-6 days) and tried with lower concentration (hence the range of (1/100- 1/10 000mg) / ml). And after application the sides come very fast. And also almost impossible to have placebo of symptoms like "(I get tired to the extent I barely can't get up from my bed, pain in my joints, brain fog, back pain etc.)"

 

[Kevand]

Very severe systemic reaction, and with a dose as low as this I probably developed immune reaction of some sort altough the symptoms correlate well with "5-alpha inhibiting symptoms".

 

[Swiss_Tampons]

Dude, no offense, but....today you reported having finasteride-like effects within one week of topical pumpkin seed oil. Today you also said that you've got cognitive and mood enhancement within 3 days of topical rosemary and jojoba oil.

What we can see here is that are several bogus studies that you are impressively embodying. Dude, come on. Don't let those crappy ''alternative medicine'' lobby-backed studies poison your mind.

 

[Afro_Vacancy]

Dude, no offense, but....today you reported having finasteride-like effects within one week of topical pumpkin seed oil. Today you also said that you've got cognitive and mood enhancement within 3 days of topical rosemary and jojoba oil.

What we can see here is that are several bogus studies that you are impressively embodying. Dude, come on. Don't let those crappy ''alternative medicine'' lobby-backed studies poison your mind.

I don't know, I've seen other people claim effects from pumpkin seed oil, I'm willing to believe that it's a weak 5ar inhibitor.

Rosemary oil isn't linked to 5ar as far as I know, it's an anti-fungal and anti-inflammatory, unless I'm mistaken. That's why it's suggested to be of modest benefit for hair.

 

[Kevand]

Dude, no offense, but....today you reported having finasteride-like effects within one week of topical pumpkin seed oil. Today you also said that you've got cognitive and mood enhancement within 3 days of topical rosemary and jojoba oil.

What we can see here is that are several bogus studies that you are impressively embodying. Dude, come on. Don't let those crappy ''alternative medicine'' lobby-backed studies poison your mind.

I don't let anything poison my mind and lobby-backed? u sure you are not talking about BP?
I have done research and have began treatment with the most evidence-supported treatments. Unfortunately I can't tolerate finasteride, I wish I could but I can't. Don't diminish my symptoms as placebo/nocebo. There is no reasonable doctor that would be doubting that symptoms to this degree is due to a physiological cause. I have tried finasteride several times and they are 100 % correlated with extreme side-effects that make me totally unfunctional. My symptoms and effects of topical pumpkin seed (also tried oral) are very most likely also due to real effects although I haven't tested far enough to be as certain as I am with finasteride.
Although placebo/nocebo can be powerful you don't suspect it if you take a drug and it several times correlates with and give severe symptoms with no reasonable psychosomatic cause or connection.
I can also say that I had no idea that rosemary had any possible cognitive-enhancing properties before I tried and googled it after the effects. Also a little careless to write that I experienced cognitive enhancing effects as that would need testing with controlled parameters. But I felt directly after applying 0,5 % rosemary oil a mood lift and increase of focus each time after three applications. I then google with the tags "rosemary focus mood" to realize that other had experienced same effect and some research paper evaluating this subject.

 

[Kevand]

Also I don't know if this give me legitimation for not being a desperate crazy alternative-medicine poisoned voodoo guy, but I am a medical student and part-time researcher.

 

[resu]

If people using 1mg still lose ground what makes you think this amount will be beneficial? It won't.

 

[smyth01]

If people using 1mg still lose ground what makes you think this amount will be beneficial? It won't.

I think the idea is to lower it to the point where dht is still reduced, but hopefully avoiding other effects in the body associated with finasteride. However, if dht is lowered, he is still going to the standard sides (and the sides he has mentioned), so this is a pretty pointless experiment.

 

[Afro_Vacancy]

Also I don't know if this give me legitimation for not being a desperate crazy alternative-medicine poisoned voodoo guy, but I am a medical student and part-time researcher.

How can 0.0001 mg of finasteride possibly be inhibiting your erections?

Even 0.01 mg ... that corresponds to a 15% reduction in DHT. That is comparable to what you should be getting day to day due to variations in sleep, diet, stress, etc.

 

[Kevand]

I think the idea is to lower it to the point where dht is still reduced, but hopefully avoiding other effects in the body associated with finasteride. However, if dht is lowered, he is still going to the standard sides (and the sides he has mentioned), so this is a pretty pointless experiment.

No unlike trying microdosing orally the point with my experiment was to locally reduce dht while avoiding dht-reduction systemic. A valid and logical experiment.
I presumed that 0,01 mg finasteride orally should have almost zero effect systemic and began from there with a topical experiment to be certain of no systemical interference in my results.

 

[Kevand]

How can 0.0001 mg of finasteride possibly be inhibiting your erections?

Even 0.01 mg ... that corresponds to a 15% reduction in DHT. That is comparable to what you should be getting day to day due to variations in sleep, diet, stress, etc.

Probable not a good idea to translate a study-result to every individual, a 15 % reduction is what you would expect in average. And also for the sample group of 0,01 mg we should take into account the variation in the group. If I remeber correctly it was like 100 persons in each dose-gorup, perhaps I am 1/10 000 or one in a million.
Also I have not experienced any ED or libido problems while on finasteride. Only increased libido at start.

 

[Afro_Vacancy]

Probable not a good idea to translate a study-result to every individual, a 15 % reduction is what you would expect in average. And also for the sample group of 0,01 mg we should take into account the variation in the group. If I remeber correctly it was like 100 persons in each dose-gorup, perhaps I am 1/10 000 or one in a million.
Also I have not experienced any ED or libido problems while on finasteride. Only increased libido at start.

It seems like if you only have one or two molecules of 5ar in your body (hyperbole) then inhibiting them will not affect you.

I just don't see how this is possible.

 

[Kevand]

It seems like if you only have one or two molecules of 5ar in your body (hyperbole) then inhibiting them will not affect you.

I just don't see how this is possible.

I currently believe that most likely I have an immunulogical reaction against the drug but I don't dismiss 5-ar related cause although very low dose. 1/10 000 mg finasteride corresponds to 1,6 * 10^14 millions finasteride molecules put in relation to the amount 5-ar in body it should be little. 10^12-10^18 cells in body each expressing and producing how many 5-ar proteins? very hard analyze.
The best would be simply to test dht before and after to exclude 5-ar inhib related sides.

 

[Kevand]

If this would be 5-ar related sides which I don't think then probably:
I have a very slow production of 5-ar
Very slow metabolization of finasteride
Finasteride bind extremely effeciently to targetmolecule
Very sensitive to dht-change
And etc