ME again proxiphen for acne?

[HARM1]

OK so proxiphen has spironolactone wich should take care of SEBUM. NOW I know an amune response is envolved in the forming of acne, BUT is the emune response envolved in male pattern baldness the same as in acne? My guess is no since one is a response to bacterium and male pattern baldness is probably a auto emune response. Does anybody have an idea?

What about the try out that bryan did trying to slow bodyhair with spironolactone? hm.. well you taughts?

 

[Felk]

Proxiphen for acne - to be perfectly blunt, a very silly idea IMHO.

For one thing it's incredibly expensive for acne, a face is much larger than some temples. For another the only thing I can think of in it which would really help could be the spironolactone, and you could use that separately anyway for _much_ cheaper. Also, spironolactone for acne is stepping into the unknown as it is. Though I'm keen to experiment with it alone. Check out my thread in the experimental section on spironolactone as a facial cream for acne.

Perhaps the copper peptides might work on the face for wrinkles in a similar way as they do for hair loss, but who's to say they do, or if they would have any action on acne?

But it's got 3 other growth stimulants - minoxidil, NANO and phenytoin... so it will probably just make your face hairy! Not to mention how people complain about minoxidil causing water retention in their face when applied to their head, let alone their face!

Also, even if your strange theory about the immune response is correct and it's the same as in acne, what on earth made you think of proxiphen? I know Dr P thinks this response is important in male pattern baldness, but to my knowledege there certainly aren't any immuno suppressants in proxiphen.

 

[Bryan]

What about the try out that bryan did trying to slow bodyhair with spironolactone?

I never did try that.

But the use of topical spironolactone for acne is by no means a new or novel idea. I have at least one study that successfully tested it for that, and two or three others that measured sebum production with topical spironolactone (with mixed results).

Bryan

 

[Felk]

I found 3 successful studies on topical spironolactone. and acne, actually. I posted them here

http://www.hairlosstalk.com/discussions ... hp?t=30112

All i got as a response was CCS crunching numbers out loud, regarding how much he'd buy, hehe.

When i say it's "stepping into the unknown" using topical spironolactone for acne, what I was getting at was that it's not really a commonplace treatment, and one that hardly anyone is really familiar with. Here is a doctor from a skin care forum discussing it...

Cosensus seems to be than topical antiandrogens are largely ineffective and systemic ones are only suitable for women with abnormal androgen excess.

http://www.smartskincare.com/forum/viewtopic.php?t=2084

its from there i found the successful studies on topical spironolactone and acne

 

[Bryan]

I found 3 successful studies on topical spironolactone. and acne, actually. I posted them here

http://www.hairlosstalk.com/discussions ... hp?t=30112

Only the first one was specifically on acne.

Bryan

 

[Felk]

Oh yes i suppose so, but one was involving topical spironolactone. and patients with acne, and the other was about reducing sebum secretion rates, and ended with a suggestion that this might be a useful treatment for acne sufferers with high sebum secretion rates.

I must confess the second study went over my head. A "reduction of the autoradiographic granules" was something i couldn't get my head around, but I knew it meant it was proof that spironolactone was inhibiting dihydrotestosterone in people with acne. Upon closer examination i guess it doesn't say anywhere in this study about any results from this inhibition in terms of acne treatment.