Making my own Nizoral Shampoo and Minoxidil/Ketoconazole Topical

[CompoundingPharmD]

I had a family member contact me and ask about Nizoral shampoo not being available. Being a compounding pharmacist, he knew I could make something for him. We got to talking and after some research, we decided to develop our own trial:beer:

I am compounding a ketoconazole 1% shampoo for him and a Minoxidil 5%/Ketoconazole .25% topical solution to use twice daily. Have never seen this combination used and finasteride/dutasteride is not an option for him(drug-drug interactions).

He has agreed to take pictures and post his results over the next 6 months. He has been a lurker here for years and I figured maybe some folks may benefit from our "research". Keep you posted!

 

[kthxbi]

you don't think nizoral twice daily would absolutely fry his hair?

either way - interested to see how this works.

 

[CompoundingPharmD]

This is what he has decided on. The shampoo will be used 2-3x/week and the minoxidil/ketoconazole twice daily which is why he wants 0.25%. If it causes excessive dryness, I mentioned that we could go down to whatever % he would like (I recommended 0.1%)...we shall see.

 

[cthulhu]

why not just get regenpure? It has 1% ketoconazole just like nizoral

 

[resu]

Use ciclopirox olamine instead or piroctone olamine for the minoxidil combo.

 

[andrew lincoln]

you don't think nizoral twice daily would absolutely fry his hair?

It would mine.

 

[HairShocka]

I use Nix daily. Is this a bad thing?

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*nizoral

 

[rwhairlosstalk]

CompRx, I was thinking of the same and wondered about a topical (because these have been more effective for me than the internal) anti androgenic item and minoxidil, but felt that spironolactone would be a better option because it's safer internally and therefore may be safer all around. I'm just wondering which is a stronger anti androgen, keto or spironolactone (at the same concentration).

 

[Justlookin]

I had a family member contact me and ask about Nizoral shampoo not being available. Being a compounding pharmacist, he knew I could make something for him. We got to talking and after some research, we decided to develop our own trial:beer:

I am compounding a ketoconazole 1% shampoo for him and a Minoxidil 5%/Ketoconazole .25% topical solution to use twice daily. Have never seen this combination used and finasteride/dutasteride is not an option for him(drug-drug interactions).

He has agreed to take pictures and post his results over the next 6 months. He has been a lurker here for years and I figured maybe some folks may benefit from our "research". Keep you posted!

Hey, I know it's a long shot, but how did you formulate the ketoconazole topical? And how were the results?

 

[xaragedom]

Use ciclopirox olamine instead or piroctone olamine for the minoxidil combo.

Hey, Why you advise to use these compounds instead of ketoconazole with minoxidil?? Do you think ketoconazole can decrease minoxidil efficency? Just asking cause I was thinking about it latelly because I read that ketoconazole blocks PXR recepor which might be a receptor through which cells control sulfotransferase expression so that would decrease minoxidil sulfate in our scalp.

 

[resu]

Hey, Why you advise to use these compounds instead of ketoconazole with minoxidil?? Do you think ketoconazole can decrease minoxidil efficency? Just asking cause I was thinking about it latelly because I read that ketoconazole blocks PXR recepor which might be a receptor through which cells control sulfotransferase expression so that would decrease minoxidil sulfate in our scalp.

You're replying to a post made in 2013, I don't know, probably a study I read at the time. Stiprox 1.5% is a good shampoo and the active ingredient is ciclopirox.