Hello,
I made a custom topical together with Elsom Research. They used their best nano technology without alcohol or ppg to formulate the topical. I've not been using it that long, about 1.5 months, but it relieves an itchy head and makes my hair look healty.
Comments and or suggestions are appreciated since the topical is under constant development.
Here are the ingredients and explanation:
Ingredients: water, extracts of apple peel, grape seed, bayberry, green tea, pomegranate, brown kelp and cinnamon; borage oil, phosphatidycholine as Nanosomes, ascorbyl palmitate, lavender oil, potassium malate, cyclodextrin, stigmastanol, climbazole, adenosine, melatonin, d-alpha tocopherol, choline bitartrate, ferulic acid, gamma oryzanol, creatine monohydrate, allantoin, l-taurine, zinc oxide, glucoseamine sulfate, tea tree oil, imidurea, methyl paraben, propyl paraben, xanthan gum.
Bayberry root bark
-Decreases 5A Reductase with 80.7%. (1)
-Why Bayberry works on humans (2).
-SOD activity (3).
Green tea
-EGCG (epigallo-catechin-3-gallate) is a powerful anti-oxidant.
-EGCG decreases 5A Reductase Type 1.
-Increases the anti-apoptotic enzyme Bcl-1 (4).
-Study shows 1mg EGCG suppresses DHT with 97% at the androgen receptor. It's even stronger then Testosterone (5).
Apple Peel, Grape Seed extract
-Decrease the inhibitory growth factor PKC.
-Loaded with procyanidins, “the natural minoxidil†(6) (7).
-Source of ellagic acid, counters the effects of TGF-B ('8').
Creatine
-Reduces Caspase 3. Caspase 3 is an end target of DHT which signals cell death (9).
-Prevents ATP depletion.
Adenosine
-Adenosine stimulates the growth factor Fibroblast Growth Factor-7 en vascular endothelial growth factor (VEGF) in hair cells. The Watanabe study was an randomized double-blind trial with 104 volunteers with Androgenetic Alopecia which used a adenosine (0.75%) topical lotion or a niacin amide (0.1%) topical lotion twice daily for 6 month. The results showed that adenosine was significantly superior to niacin amide and both treatments resulted in a significantly decreased ratio of vellus-like hair and also significantly increased the ratio of thick hair, but did not change hair density. Adverse effects were not found (10).
Phosphatidic acid, Nanosomes
-The addition of transforming growth factor beta1 to hair epithelial cell cultures concentration-dependently decreased cell growth and induced apoptosis; however, addition of phosphatidic acid to the culture neutralized the growth-inhibiting effects of transforming growth factor beta1 and protected the cells from apoptosis (11).
S-Maltoside
-Stimulates the growth factor aFGF.
Borage oil
-Source of GLA.
-Stimulates VEGF.
-Very good anti-inflammatory.
Tea Tree oil
-Antiseptic, antifungal, dandruff treatment, kills Candida, treatment for acne (12) (13).
Laminaria
-Laminaria stimulates "stem cells" which activate the anagen fase (14).
Ascorbic acid
-Ascorbic acid stimulates mRNA levels of IGF-1 with 3.8x and therefore the growth of dermal papilla cells. People who don't respond to Finasteride seem to have low IGF-1 in their scalps (15).
Pomegranate
-Antioxidant and anti-inflammatory, also protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. It is also used for prostate cancer therapy and is also relevant to hairloss.
-Reduces TNF-a, MMP-9 and MMP-1 (16) (17) ('18').
Cinnamon
-Anti-microbial, affects lipid and sugar levels, cinnamon oil for skin/scalp infestation of lice and other pests, most important to skin the anti-peroxide effect with high value prevention of lipid peroxidation.
Melatonin
-Increases anagen rate in humans (19) (20).
L-taurine
-Anti-oxidant, effective in improving the physico-chemical properties of skin and therefore in maintenance of more youthful characteristics of skin (21).
-Anti-Fibrosis (22).
Sources:
(1) http://www.jstage.jst.go.jp/article/bpb/24/3/259/_pdf
(2) http://www.hairsite2.com/m390zo9/_disc390/000000c4.htm
(3) http://www.ncbi.nlm.nih.gov/
(4) http://www.ncbi.nlm.nih.gov/
(5) http://www.ncbi.nlm.nih.gov/
(6) http://www.ehrs.org/
(7) http://www.ehrs.org/
('8') http://www.hair2004.com/download/HairAb ... eil_II.pdf
(9) http://www.ncbi.nlm.nih.gov/
(10) http://www.hair2004.com/download/HairAb ... eil_II.pdf
(11) http://www.ncbi.nlm.nih.gov/
(12) http://www.ncbi.nlm.nih.gov/
(13) http://en.wikipedia.org/wiki/Tea_Tree_Oil
(14) http://www.ingentaconnect.com/
(15) http://cat.inist.fr/?aModele=afficheN&cpsidt=15042703
(16) http://www.ncbi.nlm.nih.gov/
(17) http://www.ncbi.nlm.nih.gov/
('18') http://www.ehrs.org/
(19) http://www.hairloss-research.org/melatonin.html
(20) http://www.regrowth.com/hairloss-remedy ... _study.cfm
(21) http://www.ehrs.org/
(22) http://www.ncbi.nlm.nih.gov/
I made a custom topical together with Elsom Research. They used their best nano technology without alcohol or ppg to formulate the topical. I've not been using it that long, about 1.5 months, but it relieves an itchy head and makes my hair look healty.
Comments and or suggestions are appreciated since the topical is under constant development.
Here are the ingredients and explanation:
Ingredients: water, extracts of apple peel, grape seed, bayberry, green tea, pomegranate, brown kelp and cinnamon; borage oil, phosphatidycholine as Nanosomes, ascorbyl palmitate, lavender oil, potassium malate, cyclodextrin, stigmastanol, climbazole, adenosine, melatonin, d-alpha tocopherol, choline bitartrate, ferulic acid, gamma oryzanol, creatine monohydrate, allantoin, l-taurine, zinc oxide, glucoseamine sulfate, tea tree oil, imidurea, methyl paraben, propyl paraben, xanthan gum.
Bayberry root bark
-Decreases 5A Reductase with 80.7%. (1)
-Why Bayberry works on humans (2).
-SOD activity (3).
Green tea
-EGCG (epigallo-catechin-3-gallate) is a powerful anti-oxidant.
-EGCG decreases 5A Reductase Type 1.
-Increases the anti-apoptotic enzyme Bcl-1 (4).
-Study shows 1mg EGCG suppresses DHT with 97% at the androgen receptor. It's even stronger then Testosterone (5).
Apple Peel, Grape Seed extract
-Decrease the inhibitory growth factor PKC.
-Loaded with procyanidins, “the natural minoxidil†(6) (7).
-Source of ellagic acid, counters the effects of TGF-B ('8').
Creatine
-Reduces Caspase 3. Caspase 3 is an end target of DHT which signals cell death (9).
-Prevents ATP depletion.
Adenosine
-Adenosine stimulates the growth factor Fibroblast Growth Factor-7 en vascular endothelial growth factor (VEGF) in hair cells. The Watanabe study was an randomized double-blind trial with 104 volunteers with Androgenetic Alopecia which used a adenosine (0.75%) topical lotion or a niacin amide (0.1%) topical lotion twice daily for 6 month. The results showed that adenosine was significantly superior to niacin amide and both treatments resulted in a significantly decreased ratio of vellus-like hair and also significantly increased the ratio of thick hair, but did not change hair density. Adverse effects were not found (10).
Phosphatidic acid, Nanosomes
-The addition of transforming growth factor beta1 to hair epithelial cell cultures concentration-dependently decreased cell growth and induced apoptosis; however, addition of phosphatidic acid to the culture neutralized the growth-inhibiting effects of transforming growth factor beta1 and protected the cells from apoptosis (11).
S-Maltoside
-Stimulates the growth factor aFGF.
Borage oil
-Source of GLA.
-Stimulates VEGF.
-Very good anti-inflammatory.
Tea Tree oil
-Antiseptic, antifungal, dandruff treatment, kills Candida, treatment for acne (12) (13).
Laminaria
-Laminaria stimulates "stem cells" which activate the anagen fase (14).
Ascorbic acid
-Ascorbic acid stimulates mRNA levels of IGF-1 with 3.8x and therefore the growth of dermal papilla cells. People who don't respond to Finasteride seem to have low IGF-1 in their scalps (15).
Pomegranate
-Antioxidant and anti-inflammatory, also protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. It is also used for prostate cancer therapy and is also relevant to hairloss.
-Reduces TNF-a, MMP-9 and MMP-1 (16) (17) ('18').
Cinnamon
-Anti-microbial, affects lipid and sugar levels, cinnamon oil for skin/scalp infestation of lice and other pests, most important to skin the anti-peroxide effect with high value prevention of lipid peroxidation.
Melatonin
-Increases anagen rate in humans (19) (20).
L-taurine
-Anti-oxidant, effective in improving the physico-chemical properties of skin and therefore in maintenance of more youthful characteristics of skin (21).
-Anti-Fibrosis (22).
Sources:
(1) http://www.jstage.jst.go.jp/article/bpb/24/3/259/_pdf
(2) http://www.hairsite2.com/m390zo9/_disc390/000000c4.htm
(3) http://www.ncbi.nlm.nih.gov/
(4) http://www.ncbi.nlm.nih.gov/
(5) http://www.ncbi.nlm.nih.gov/
(6) http://www.ehrs.org/
(7) http://www.ehrs.org/
('8') http://www.hair2004.com/download/HairAb ... eil_II.pdf
(9) http://www.ncbi.nlm.nih.gov/
(10) http://www.hair2004.com/download/HairAb ... eil_II.pdf
(11) http://www.ncbi.nlm.nih.gov/
(12) http://www.ncbi.nlm.nih.gov/
(13) http://en.wikipedia.org/wiki/Tea_Tree_Oil
(14) http://www.ingentaconnect.com/
(15) http://cat.inist.fr/?aModele=afficheN&cpsidt=15042703
(16) http://www.ncbi.nlm.nih.gov/
(17) http://www.ncbi.nlm.nih.gov/
('18') http://www.ehrs.org/
(19) http://www.hairloss-research.org/melatonin.html
(20) http://www.regrowth.com/hairloss-remedy ... _study.cfm
(21) http://www.ehrs.org/
(22) http://www.ncbi.nlm.nih.gov/
