Loss of inflammation a good thing!

[WorldofWarcraft]

After reading the below information, I am now extremely excited over the fact that my 1.25 mg daily finastride has made my insane itchy infammed scalp change to a normal, healthy, nice feeling scalp:

People and researchers who used 5AR inhibitors such as Proscar and Saw Palmetto found it helped with the hair loss but in no way shut it down or regrew much of the hair that was lost. What appears to be the ultimate cause of hair loss for most people is an auto immune response where the body actually attacks the hair follicle like some kind of foreign invader thus causing an inflammatory response. By yet unknown mechanisms, DHT causes a change in the follicle signaling the immune system to attack the follicle and your hair starts falling out (If you take a close look, you can actually see a red line of inflammation on the scalp of some people losing their hair). How do we know this? It was discovered that the hair follicles of people losing their hair look very similar under a microscope to people who experience organ rejection after surgery. And, it has been found that the immune system suppressing drug which is used to stop the organ rejection (Cyclosporine) grows hair like crazy because it shuts down the immune response in the body. A cure you say? NO! If you take some Cyclosporine and you grow hair it will be because you have no immune system and you will get very sick and possibly die. I sh*t you not-don't mess with this stuff. Anyway, though DHT is clearly important in the cause of hair loss, it is not the final cause and a new race has been started to address the inflammatory response which ultimately causes you hair to fall out. Clearly, you have to attack hair loss from both the DHT and inflammatory response, and that's what most of this article is about....sort of. There are also other factors related to hair growth and hair loss such as nutrition, SODases, Nitric Oxide (NO) and others, but DHT and the immune response are the two biggies.

http://www.thehouseofjuice.com/viewtopi ... f4bb5f1df5

 

[So]

That's what it's all about, inflammation. There are many pathways including DHT that contribute to inflammation so the best approach is to combat as many of them as possible that you feasibly can.

Combating DHT alone is a futile effort and minoxidil is merely a masking effect that does not address the internal imbalance issue although they are essential to any regimen.

Oxidative stress my friend is the mother of inflammation.

 

[WorldofWarcraft]

That's what it's all about, inflammation. There are many pathways including DHT that contribute to inflammation so the best approach is to combat as many of them as possible that you feasibly can.

Combating DHT alone is a futile effort and minoxidil is merely a masking effect that does not address the internal imbalance issue although they are essential to any regimen.

Oxidative stress my friend is the mother of inflammation.

I use nizoral shampoo everyday also, but my inflammation stopped before I added the shampoo. Considering the massive turnaround my hair has had in the inflammation department, I am not going to mess with my great results.

Are you sure its about inflammation and not about your immune system attacking your hair follicles and that inflammation is a result of this?

I used to make my g/f mad by taking two 20 minute hot showers a day to try to try to calm my insane itching. Now adays I only take small showers and could really do without them if it wasn't for the obvious sanatary benefits.

Heck, I would stick on the big 3 even if I wasnt going bald just because my scalp feels so much better. (now if I could just regrow some damn hair)

 

[So]

Well yes to rephrase it better, it is the immune response to _x_ resulting in inflammation.

Exactly what _x_ is and THE question of why our immune systems are attacking our hair follicles is really beyond me and I don't buy the fact that it's simply because of excess DHT. The reason for my doubt is that once we reduce DHT to acceptable levels or beyond hair loss in many cases still continues as if unhindered by your attempt. This suggests to me that DHT is but one pathway associated with hair loss.

I think the rate of success that you will have in combating hair loss is going to weigh largely on your white blood cells and their ability to address inflammation.

This is where we get back to the topic of cellular oxidative stress and the importance of anti-oxidative elements.

White blood cells = Leukocytes which act as Phagocytes and scavenge, or literally EAT dead cells, bacteria and much more. However one of the most notable importances of Phagocyte cells is that they are the primary driving force behind wound healing.

I believe if this process is diminished in anyway by oxidative stress amongst other things then you will have some trouble in yielding results and this is where I believe I stand.

Although I would consider myself healthy and someone whom employs a sound, holistic diet with great consideration of food types and nutritional benefit, I have yet to produce any measurable result.

My conclusion is that for me as many others, some pathways are being left un-addressed where as those who maintain on the Propecia alone for example may be in more cellular harmony if that makes sense.

By the way I use Nizoral once every second or third day and it makes my scalp feel great. I compliment this with Fish Oil capsules which reduce inflammation and provide relief however again this is merely masking an underlying problem.

 

[newguy2006]

Aren't you the guy who's totally against any holistic/naturalist remedies? If so, you're missing out on a lot of great ways to reduce inflammation by non-pharmaceutical means.

IMO - and I'm not some dreadlocked hippy either - "candida" is definitely one of the main contributing factors to much of the world's hair loss. It's a systemic fungal infection that is brought on by lots of factors, especially -

* high sugar diets (20-21st century diets are packed with refined sugar)

&

* use of antibiotics (which are always over-prescribed these days)

I understand that nizoral, t-gel, aloe, finasteride, etc. - all of those things can make your scalp feel great. But if you try avoiding all refined sugar for a few weeks, I guarantee you that you'll notice a drastic change as well. Night and day.

Oh, and for all you tea lovers out there? Red Rooibos tea is supposedly an excellent natural anti-inflammatory, and is loaded with anti-oxidants as well (tastes good too).

IMO, a fusion of western and eastern medicine is the best for staying healthy and keeping your hair.

 

[So]

There was some good talk about Candida on another forum.

It is but another avenue in which people should SERIOUSLY investigate.

Also I've just learned of Red Roobois tea courtesy of H/B from this forum and from my research it is technically not a tea per say, however it's anti-oxidative properties are very high and considering the recent talk about Green Tea potentially being bad for your hair it would be an excellent alternative.

I still drink Green Tea because I love it and recently have added White Tea which is proposed to be stronger in anti-oxidative properties than Green however if Green is reportedly bad for your hair then I would assume White is also.

I haven't tried Red yet!

 

[powersam]

wouldnt one of those one dose oral thrush treatments clear up candida quickly?

 

[So]

Good ?ion

As far as I know you need to modify your diet heavily and detox both the liver and colon "properly" and not in a manner that is considered to be half-assed.

Many people have a form of Candida, even if very light or mild and somewhat unnoticeable. Western diets proliferate Candida and array of other situations such as Adrenal Fatigue, CFS, etc and it all contributes to hair health.

 

[harold]

Well yes to rephrase it better, it is the immune response to _x_ resulting in inflammation.

Exactly what _x_ is and THE question of why our immune systems are attacking our hair follicles is really beyond me and I don't buy the fact that it's simply because of excess DHT. The reason for my doubt is that once we reduce DHT to acceptable levels or beyond hair loss in many cases still continues as if unhindered by your attempt. This suggests to me that DHT is but one pathway associated with hair loss.

I think the rate of success that you will have in combating hair loss is going to weigh largely on your white blood cells and their ability to address inflammation.

This is where we get back to the topic of cellular oxidative stress and the importance of anti-oxidative elements.
....

Well I think its beginning to look like DHT causes massive oxidative stress in the hair follicle which triggers thee release of TGF-Beta which sends the cell into apoptosis in effect saying "I am one sick cell, kill me now". So I think that oxidative stress is and will soon be more clearly revealed as the mediator between DHT and the immune response/inflammation based on that unpublished abstract from the EHRS last year.
hh

 

[harold]

Little bit about oxidative stress and apoptosis.
hh

Biochem Pharmacol. 1999 Feb 1;57(3):231-45.
Reactive oxygen intermediates as mediators of programmed cell death in plants and animals.

* Jabs T.

Institute for Biology III, RWTH Aachen, Germany. THORSTEN.JABS@MSM.BASF-AG.DE

Programmed cell death (PCD) is a physiological process occurring during development and in pathological conditions of animals and plants. The cell death program can be subdivided into three functionally different phases: a stimulus-dependent induction phase, an effector phase during which the wide range of death-stimuli are translated to a central coordinator, and a degradation phase during which the alterations commonly considered to define PCD (apoptotic morphology of the nucleus and chromatin fragmentation) become apparent. Recent studies suggest that mitochondrial permeability transition is the central coordinator of PCD and deciding whether or not a cell will die. There is increasing evidence that reactive oxygen intermediates (ROI) serve as direct and indirect mediators of PCD in mammalian and plant cells. Overexpression of genes encoding pro- and antioxidant enzymes in transgenic animals and plants has been informative regarding the function of ROI. Recent data imply a dual role of ROI in the apoptotic process: first, as a facultative signal during the induction phase, and, second, as a common consequence of mitochondrial permeability transition leading to the final destruction of the cell. The present review discusses and compares new insights into the function of ROI during PCD in mammalian cells and in human and plant diseases.

 

[powersam]

funny that candida would come up now, as ive been reading a lot about male yeast infections in the last few days. coincidental.

theres supposed to be some very easy test for candida that you can do by spitting in a glass, but i cant remember the specifics. i'll try find it later on.

 

[So]

Yeah spit into a glass of water first thing in the morning and if your saliva grows legs and sinks to the bottom apparently that is a *sign*.

Of course how accurate a test this is remains to be seen!

 

[Rage]

Nizoral is very effective against yeast infections!