L'Oreals new patent for Alopecia...... | HairLossTalk Forums

L'Oreals new patent for Alopecia......

Discussion in 'Hair Loss and Alopecia Published Studies' started by michael barry, Oct 28, 2005.

  1. michael barry

    michael barry Senior Member

    Joined:
    Feb 24, 2005
    Messages:
    1,809
    Likes Received:
    12
    Dislikes Received:
    0
    L'OREAL PATENTS AN ORAL TAURINE NUTRIENT
    COMPOUND FOR THE TREATMENT OF
    ANDROGENIC ALOPECIA

    L'OREAL - A large cosmetic and hair care company based in France was recently issued a US Patent for an oral hair growth/hair loss prevention compound that utilizes the amino acid taurine in combinaton with certain catechins, polyphenols, and essential fatty acids. Of particular interest are the assertions and claims made for the oral administration of taurine in combination with polyphenols, catechins and EFA's and its implications for the treatment of hair loss.
    The usage of taurine at a dose of approximately 500 mg daily corrects what they term the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
    Additionally, it is claimed that specific oral extracts rich in polyphenols, proanthocyanidins, catechins, and essential fatty acids prevent the "cutaneous activation of testosterone and increases in sebaceous function, without sexual side effects". The specific compounds noted or grape seed extract, green tea extract, red wine extract (resveratol) in various milligram dosages that approximate what is already recommended in our protocol. The essential fatty acid compounds noted were a combination of omega 6 and omega 3 fatty acids. The omega 6 sources included Evening Primorose Oil, Borage Oil, and Black Currant Oil. The Omega 3 sources included fish and walnut oils.

    Below are excerpts from the patent itself:
    The use of taurine and/or hypotaurine and/or salts thereof that are acceptable in an oral composition, for the preparation of an oral composition that is useful for treating and preventing aging of the pilosebaceous unit and/or alopecia.

    The use as claimed in claim 1, characterized in that the oral composition is useful for reducing or preventing impairment of the hair follicle induced by rigidification of the connective sheath.

    The use as claimed in claim 1, characterized in that the daily dose of taurine and/or hypotaurine and/or acceptable salts thereof, as taurine equivalent, is between 10 and 500 mg/day

    The use as claimed in claim 1, characterized in that the taurine and/or hypotaurine and/or acceptable salts thereof are used in combination with at least one of the compounds chosen from fatty acids, polyphenols and extracts comprising the same.

    The use as claimed in claim 12, characterized in that the polyphenols are chosen from flavones, flavonols, isoflavones, anthocyanins, flavanols, proanthocyanidins and flavanones, and stilbenes

    The use as claimed in claim 16, for the preparation of an oral composition that is useful for reducing or preventing the impact of testosterone on the pilosebaceous unit.

    The use as claimed in claim 12, characterized in that the daily dose of polyphenols is from about 0.5 to 1000 mg/day

    A cosmetic process for treating and preventing disorders of the pilosebaceous unit via the oral administration of at least one fatty acid, one polyphenol or an extract comprising the same, optionally in combination with taurine and/or hypotaurine and/or acceptable salts thereof

    The present invention relates mainly to the use of taurine and/or hypotaurine in oral compositions for preventing and treating functional disorders of the pilosebaceous unit and especially for preventing and treating alopecia. The invention is also directed toward the use of fatty acid(s) polyphenol and/or extracts containing the same, optionally in combination with taurine in food supplements for treating and preventing these same disordersAmong the causes of alopecia, it has in fact been determined that impairment of the perifollicular connective tissue was reflected by rigidification of the connective sheath, which is thought to explain the miniaturization of the hair follicle, a sign of aging of the pilosebaceous unit.

    [0005] Furthermore, these impairments in the hair are often accompanied by impairment in the condition of the scalp, such as the abundant production of sebum. Hypersecretion of sebum or seborrhea and its consequences, for example acne, often appear during puberty, but may continue into adulthood, especially in women, for hormonal reasons.

    The Applicant has demonstrated, surprisingly, firstly that taurine is advantageous in regulating the impairment of the connective tissue of the hair follicle, and may thus be used advantageously in the treatment and prevention of aging of the pilosebaceous unit and/or of alopecia. Specifically, it has been possible to observe that taurine reduces the incorporation of proline without impairing that of leucine; this shows the advantage of taurine for specifically reducing the accumulation of collagen, without impairing the overall synthesis of proteins

    Moreover, the Applicant has noted that favoring an oral administration made it possible to obtain a hair-loss-preventing effect without inducing a stimulatory effect on the growth of the pilous system other than the hair system. It thus found that an oral administration of the active materials under consideration according to the invention was particularly effective for maintaining a good head of hair by acting on the hair density, i.e. the number of hairs per cm.sup.2 of scalp, and by reducing the heterogeneity of the hair diameters

    In one particular embodiment, the taurine, hypotaurine or acceptable salts thereof is (are) administered at a dose of from 0.5 to 4000 mg per day, as taurine equivalent, the fatty acid(s) is (are) administered at a dose of from 0.5 to 5400 mg/day and/or the polyphenol(s) is (are) administered at a dose of from 0.5 to 2000 mg/day.

    By way of example, mention may be made of an extract of grapeseed containing 40% PCO, an extract of red wine containing 30% total polyphenols and/or an extract of green tea containing 30% catechins

    The procyanidin oligomers (PCO) may be used at doses of from 0.5 to 1000 mg/day and preferably 20 to 250 mg/day. They may be provided by an extract of grapeseed, which is dosed according to its PCO content. By way of example, for an extract of grapeseed containing 40% PCO, above, a dose of 150 mg/day, i.e. 60 mg/day PCO, is used.

    [0052] Moreover, the catechins may be used at doses of from 0.5 to 1000 mg/day and preferably 20 to 300 mg/day. They may be provided, for example, by an extract of green tea containing 30% catechins, the extracted dose then being about 375 mg/day, i.e. 112.5 mg/day of catechins

    The Applicant has especially demonstrated that the oral administration of a dose of 37 mg/kg/day of a red wine concentrate, which is equivalent to a dose of 220 mg/kg/day for a person weighing 60 kg, had an efficacious effect on hair loss without showing any adverse side effects on the prostate. This is especially illustrated in the examples below

    9 FORMULATION OF SUGARCOATED TABLET TYPE mg/sugarcoated tablet Taurine 50 Grapeseed extracts (40% PCO) 100 Green tea extracts (30% catechins) 125 Zinc sulfate (22.75%) 22 Excipient for the core of the sugarcoated tablet Microcrystalline cellulose 70 Encompress .TM. 60 Magnesium stearate 3 Anhydrous colloidal silica 1 Coating agent Shellac 5 Talc 61 Sucrose 250 Polyvidone 6 Titanium dioxide 0.3 Colorant 5Example 21

    19 FORMULATION OF SUGARCOATED TABLET TYPE mg/sugarcoated tablet Taurine 50 Grapeseed extracts (40% PCO) 50 Green tea extracts (30% catechins) 125 Zinc sulfate (22.75%) 22 Excipient for the core of the sugarcoated tablet Microcrystalline cellulose 70 Encompress .TM. 60 Magnesium stearate 3 Anhydrous colloidal silica 1 Coating agent Shellac 5 Talc 61 Sucrose 250 Polyvidone 6 Titanium dioxide 0.3 Colorant 5

    [0169] This type of sugarcoated tablet may be taken 1 to 3 times a day.

    0066] The sources of .gamma.-linolenic acid will be chosen from plant oils (evening primrose oil, borage oil, blackcurrant pip oil and hemp oil), and extracts of spirulina, Spirula maxima and S. platensis.

    [0067] For the polyunsaturated fatty acids of the n-3 series, known as "omega-3" polyunsaturated fatty acids, the first is alpha-linolenic acid (18:3.omega.3); stearidonic acid (C18:4n-3) is also a fatty acid that is particularly advantageous in the invention.

    [0068] Plant oils from walnut (Juglans regia) and from soybean (Glycina max), for example, are rich in omega-3 polyunsaturated fatty acids in the same respect as fish oils.

    [0069] The .omega.3 polyunsaturated fatty acids are found, via the food chain, in zooplankton, crustaceans/molluscs and fish.

    [0070] Fish oils constitute the main industrial source of EPA (eicosapentaenoic acid=20:5 .omega.3) and DHA (docosahexaenoic acid=22:6 .omega.3). However, microalgal biomasses may also constitute a raw material for extraction of .omega.3 fatty acids.



    It is more than gratifying to see a major international corporation pursue a patent for some of the same recommendations we have been making for years. The mixing of taurine with varying combinations of these nutrients is essentially what has been patented. By reviewing the often confusing labyrinth of patent application text, one can decipher the ingredients used, and their dosages, and have "patent protected" information in hand that can be readily utilized long before a "patented" and often overpriced product becomes commercially available. In this case L'OREAL'S patented oral hair loss treatment can be easily formulated by using a combination of the disclosed ingredients.






    Featured Products

    Taurine Capsules -
    1000 mg, 50 capsules
    Price: $8.95 US
    Taurine is a conditionally essential amino acid produced from cysteine by the body and found abundantly in the body, particularly throughout the excitable tissues of the central nervous system, where it is thought to have a regulating influence. However, taurine is deficient in many diets and may not be sufficiently produced by the body in certain disease states. Researchers at L'Oreal have evidence showing that when it is used in a sufficient milligram dosage, it will prevent aging and rigidification of the pilosebaceous unit, thus correcting hair loss.

    Supplement Facts:
    Serving Size 1 capsule
    Servings Per Container 50
    Amount Per Serving
    Taurine 1000 mg
    Other ingredients: rice flour, magnesium stearate, gelatin, and water.
    This product contains NO wheat, yeast, gluten, corn or dairy. Contains NO sugar, artificial sweeteners, colors, flavors or preservatives.
    Dosage and Use:
    Take one to four capsules daily or as recommended by a healthcare practitioner.
    This product can be taken with or without food.




    Root Food
    120 capsules
    Price: $22.95 US

    Healthy hair needs proper nutrient raw materials. Durk Pearson and Sandy Shaw have designed Root Food® to provide increased levels of nutrients that hair requires for looking and growing its best. Root Food contains high levels of taurine and its precursor L-Cysteine, in addition to 5 alpha reductase inhibitors.

    Supplement Facts:
    Serving Size 1 capsule
    Servings Per Container 120
    Amount Per Serving:
    Vitamin A (100% as beta carotene) 1250 IU
    Vitamin C (as calcium ascorbate, niacinamide ascorbate, ascorbyl
    palmitate) 370 mg
    Vitamin D3 (as cholecalciferol) 50 IU
    Vitamin E (as DL-alpha tocopheryl acetate) 25 IU
    Thiamine (vitamin B-1) (as thiamine hydrochloride) 1.2 mg
    Riboflavin (vitamin B-2) 30 mg
    Niacin (as niacinamide ascorbate, niacin) 38 mg
    Vitamin B-6 (as pyridoxine hydrochloride) 1.3 mg
    Folic acid 100 mcg
    Vitamin B-12 (cyanocobalamin) 25 mcg
    Biotin 250 mcg
    Pantothenic acid (as D-calcium pantothenate) 20 mg
    Calcium
    (as calcium ascorbate, D-calcium pantothenate) 30 mg
    Zinc (as zinc gluconate) 3.3 mg
    Copper (as copper gluconate) 190 mcg
    Selenium (sodium selenite) 6.25 mcg
    Manganese (as manganese gluconate) 230 mcg
    Chromium (as chromium aspartate) 25 mcg
    L-cysteine (as L-cysteine hydrochloride) 175 mg
    Taurine 62.5 mg
    Inositol 25 mg
    Other ingredients: gelatin.
    This product contains NO wheat or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.
    Dosage and Use:
    As a dietary supplement, take one capsule with each meal and one at bedtime. (4 capsules daily)
    Caution:
    If you have kidney disease or the genetic metabolic defect 6-GPD deficiency, consult your physician before use.


    Grapeseed Extract with Resveratrol
    100 mg, 60 capsules
    Price: $36.00 US

    Life Extension's Grapeseed Extract with Resveratrol formula provides a concentrated blend of standardized proanthocyanidins found in grape seed and skins. The proanthocyanidins and flavonoids in this new formula are rapidly absorbed and distributed throughout the body, helping to eliminate free radicals while promoting healthy collagen formation.
    Unlike other products that contain only proanthocyanidins, this new blend also provides standardized resveratrol, the polyphenol in red wine that has shown so many health benefits. Researchers at L'Oreal contend that oral administration of this compound has been efficacious in treating hair loss.

    Supplement Facts:
    Serving Size 1 capsule
    Servings Per Container 60
    Amount Per Serving
    Vitamin C (as calcium ascorbate) 250 mg
    Calcium (as calcium ascorbate) 25 mg
    Proprietary Blend: 100 mg
    Oligomeric Proanthocyanidins1
    (from Masquelier's OPC2 grape seed extract) (Vitis vinifera) [98% average content of polyphenolic compounds, procyanidolic value 90%]
    Typical profile: (to equal 98% average content of polyphenolic compounds)
    Proanthocyanidins 65%
    OPC-precursors (catechin, epicatechin) 30%
    Gallic acid 3%
    Leucoselect®3 Grapeseed extract (Vitis vinifera)
    [standardized for 95% proanthocyanidins]
    Resveratrol [from whole red grape (Vitis vinifera) and Polygonum cuspidatum (root) extract] 20 mg
    Other ingredients: gelatin, magnesium stearate, brown rice flour.
    This product contains NO wheat, yeast, gluten, corn, or dairy. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.
    1-Oligomeric proanthocyanidins are powerful antioxidants that help protect cells and tissues from free radical-initiated damage.
    2- Masquelier's OPC Grape Seed Extract product is the original material, processed exclusively under French patent number 9408615.
    3- Leucoselect is a registered trademark of Indena U.S.A. U.S. Reg. No. 2294439.

    Dosage and Use:
    Take one capsule daily or as recommended by a healthcare practitioner.
    This product can be taken with or without food.



    Resveratrol
    60 capsules
    Price: $32.00 US
    Findings from published scientific literature indicates that resveratrol may be the most effective plant extract for maintaining optimal health.
    Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest, and other factors. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement. This whole grape extract contains a spectrum of polyphenols that are naturally contained in red wine such as proanthocyandins, anthocyanins, flavonoids, etc.
    The resveratrol used in these products is extracted from organic grapes and is in a natural matrix that includes many other polyphenols, and is the active ingredient in red wine extract.
    Supplement Facts:
    Serving Size 1 capsule
    Servings Per Container 60
    Amount Per Serving:
    Resveratrol (from 200 mg of whole grape extract) 20 mg
    Quercetin (as quercetin dihydrate) 120 mg
    Other ingredients: gelatin, rice powder, magnesium stearate.
    This product contains NO sugar, yeast, wheat, gluten, corn or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.
    Dosage and Use:
    One capsule daily with or without food.



    Mega Green Tea Extract (93%)
    725 mg, 100 capsules
    Price: $28.00 US
    Mega Green Tea Extract capsules contain an unprecedented 725 mg of either lightly caffeinated or decaffeinated 93% standardized green tea extracts, which makes it easy to obtain super-potent doses by taking only one of these low-cost capsules per day. Each Mega Green Tea Extract capsule provides 246.5 mg of EGCG.about ten times more than what is being put into commercial multivitamin supplements today. Green Tea Extract raises SHBG and lowers serum DHT, moreso when combined with soy isoflavones.
    EGCG functions as an antioxidant that is about 25-100 times more potent than vitamins C and E.16 One cup of green tea may provide 10-40 mg of polyphenols and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots, or strawberries.

    Supplement Facts:
    Serving Size 1 capsule
    Servings Per Container 100
    Amount Per Serving:
    Green tea, powdered extract (leaf) 725 mg
    Epigallocatechin gallate (EGCG) 246.5 mg
    Other polyphenols 427.75 mg
    Other ingredients: gelatin, magnesium stearate, rice flour.
    This product contains NO wheat, yeast, gluten, corn, or dairy.
    Contains NO sugar, artificial sweeteners, flavors, colors, or
    preservatives.
    The botanical extract in Mega Green Tea Extract has been concentrated and dual standardized to ensure the highest quality, consistency, and biological activity. This advanced 93/34 extract contains 93% total polyphenols (674.25 mg per capsule) and 34% Epigallocatechin gallate (EGCG) (246.5 mg per capsule).

    Dosage and Use:
    Take one capsule per day with or without food.
    Take early in the day if you find that the small amount of caffeine in Mega Green Tea Extract interferes with your sleep.

    Super EPA/DHA with Sesame Lignans & Olive Fruit Extract
    Price: $ 32.00 US

    Super EPA/DHA with Sesame Lignans & Olive Fruit Extract contains pharmaceutical-grade fish oil with a unique 35%/25% ratio of EPA/DHA. The premium fish oil in Super EPA/DHA with Sesame Lignans & Olive Fruit Extract has been tested for pollutants including dioxins, furans, PCBs and heavy metals. The oil is sourced from the purest wild sardine, anchovy, and mackerel fished in cold, pristine, deep waters off South America, where there are significantly less environmental impurities. Super EPA/DHA with Sesame Lignans & Olive Fruit Extract fish oil is the product of a healthy, fully sustainable fishery and is a renewable resource.
     Super EPA/DHA with Sesame Lignans & Olive Fruit Extract is manufactured to GMP (Good Manufacturing Practices) and HACC (Hazard Analysis and Critical Control Point) standards and are also in compliance with the Canadian Food Inspection Agency (CFIA) standards.
     Our fish oil supply is the first and only fish oil ingredient to achieve US Pharmacopoeia (USP) verification, which is the most rigorous quality assurance verification in the world. The U.S. Pharmacopoeia is the body that establishes the standards for the FDA.
     Direct access to the best fisheries in the world for manufacture of Omega-3 fish oil.
     Compliant with the Council for Responsible Nutrition's (CRN) Voluntary Monograph on Long Chain Omega-3 EPA and DHA - strict industry manufacturing standards, guaranteeing a high quality product.
    Life Extension has uncovered research that demonstrates that the addition of sesame lignans to fish oil enhances its beneficial effects. When fats are consumed, they are broken down into factors that either promote or suppress inflammatory reactions. Sesame lignans inhibit an enzyme (delta-5-desaturase) that causes dietary fats to be converted into arachidonic acid, a precursor to the toxic inflammatory factors prostaglandin E2 and leukotriene B4.
    Super EPA/DHA now has the nutrient powerhouses of sesame lignans and fortified extra virgin olive oil. To get this level of nutrients found in these high oils would require excessive consumption of the native oils adding many calories to the daily diet.
    Polyphen-OilT Olive Fruit Extract is a proprietary, fortified extra virgin olive oil complex developed by Life Extension. The naturally occurring polyphenol antioxidants are typically lost in olive juice discarded during olive oil pressing. Polyphen-OilT is highly enriched oil with olive juice extract standardized with these naturally occurring antioxidants.
    In his latest book, The Perricone Prescription, Dr. Nicholas Perricone dedicates a section to olive oil and refers specifically to hydroxytyrosol as its rare and most potent protective antioxidant. Dr. Perricone states that hydroxytyrosol slows the aging process in the skin by stabilizing the cell plasma membrane. He recommends daily olive oil ingestion for soft, shiny hair and strong nails.
    Only Life Extension's Super EPA/DHA contains the "healthy trio" of concentrated nutrients from fish oil, sesame seed oil and extra virgin olive oil.

    Supplement Facts:
    Serving Size 2 softgel
    Servings Per Container 60
    Amount Per Serving:
    Calories 22
    Calories from Fat 22
    Total Fat 2.2 g
    Cholesterol 8 mg
    Wild Fish Oil Concentrate 2000 mg
    Yielding:
    EPA (eicosapentaenoic acid) 700 mg
    DHA (docosahexaenoic acid) 500 mg
    Other Omega-3 fatty acids 100 mg
    Polyphen-OilT Olive Fruit Extract (Olea europa) 265 mg
    [standardized to 0.9% polyphenols (2.5 mg), 0.6% hydroxytyrosol (1.75 mg)]
    Sesame seed (Sesamum indicum) lignan extract 10 mg
    [standardized to 60% sesamin (6 mg)]
    Other ingredients: refined fish oil concentrate (anchovy,
    sardine, mackerel), gelatin, glycerin, colloidal silicon dioxide,
    lecithin, carob color, mixed tocopherols, and rosemary extract.
    Super EPA/DHA with Sesame Lignans & Olive Fruit Extract contains twice as much EPA and DHA as conventional fish oil capsules.

    Dosage and Use:
    Take two softgels twice daily with meals.
    Two softgels may be taken up to three times daily if so directed by a healthcare practitioner.
    Do not take with fiber supplements.
    The olive polyphenols in Polyphen-OilT protect against LDL oxidation, suppress free radicals, and stabilize cell membranes.
    Each serving of two softgels provides the amount of polyphenols equivalent to drinking two ounces of virgin olive oil.
    Caution:
    If you are taking anticoagulant drugs, use only under the supervision of your physician. Blood tests that measure clotting time can be used to ensure these nutrients are not reducing the clotting factors in your blood to abnormal levels.


    For questions concerning this update or anything related to hairloss treatment, call the toll free number below.
    These compounds can be obtained online through the male pattern baldness Buyer's Club at http://www.hairloss-research.org or by calling 1-888-577-4247.
    International: (321)733-2008.





    --------------------------------------------
    If you have subscribed to the http://www.hairloss-research.org Newsletter by accident or someone else has
    subscribed you without your permission, or
    if you ever want to remove yourself from the http://www.hairloss-research.org Newsletter
    simply visit http://www.hairloss-research.org/cgi-bi ... omcast.net
    and you will automatically be removed.

    --------------------------------------------
    --------------------------------------------
     
  2. sublime

    sublime Experienced Member

    Joined:
    Apr 11, 2005
    Messages:
    504
    Likes Received:
    1
    Dislikes Received:
    0
    :sobbing:
     
  3. jeffsss

    jeffsss Senior Member

    Joined:
    Aug 21, 2005
    Messages:
    1,436
    Likes Received:
    4
    Dislikes Received:
    0
    holy crap! you have the biggest regimine i've ever seen!
     
  4. sublime

    sublime Experienced Member

    Joined:
    Apr 11, 2005
    Messages:
    504
    Likes Received:
    1
    Dislikes Received:
    0
  5. sublime

    sublime Experienced Member

    Joined:
    Apr 11, 2005
    Messages:
    504
    Likes Received:
    1
    Dislikes Received:
    0
    I have already explained why I take Taurine and Carnisone. Everyone should be familiar with Flax and what it does to 5AR. I am also applying Emu Oil topically along with tricomin. I put a water filter in place to remove the chlorine and toxic flouride. Both of those to aggrevate hair loss and chlorine in large enough amounts will cause hair loss. Let me know if you have any questions.


    Mushroom Extract
    http://www.doctormurray.com/articles/pd ... takeBW.pdf

    Green Tea Extract
    The effects of tea polyphenolic compounds on hair loss among rodents.
    The objective of this study was to examine the effects of polyphenolic compounds, present in noncommercially available green tea, on hair loss among rodentts. In an experimental study, we randomly assigned 60female Balb/black mice, which had developed spontaneous hair loss on the head, neck and dorsal areas into two equal groups; A (experimental) and B (control). Group A received 50% fraction of polyphenol extract from dehydrated green tea in their drinking water for six months. Group B received regular drinking water. Both groups were fed regular rodent diets (Purina Rodent Chow 5001) and housed individually in polycarbonate cages. The results showed that 33% of the mice in experimental Group A, who received polyphenol extract in their drinking water, had significant hair regrowth during six months of treatment (p = 0.014). No hair growth was observed among mice in the control group, which received regular water.

    Beta Sisterol
    BACKGROUND: Androgenetic alopecia (Androgenetic Alopecia) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, Androgenetic Alopecia has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of Androgenetic Alopecia. OBJECTIVES: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of Androgenetic Alopecia. Subjects: Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate Androgenetic Alopecia. RESULTS: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit. CONCLUSIONS: This study establishes the effectiveness of naturally occurring 5AR inhibitors against Androgenetic Alopecia for the first time, and justifies the expansion to larger trials.

    Beta Glucan
    KOJAK encodes a cellulose synthase-like protein required for root hair cell morphogenesis in Arabidopsis.
    The cell wall is an important determinant of plant cell form. Here we define a class of Arabidopsis root hair mutants with defective cell walls. Plants homozygous for kojak (kjk) mutations initiate root hairs that rupture at their tip soon after initiation. The KJK gene was isolated by positional cloning, and its identity was confirmed by the molecular complementation of the Kjk(-) phenotype and the sequence of three kjk mutant alleles. KOJAK encodes a cellulose synthase-like protein, AtCSLD3. KOJAK/AtCSLD3 is the first member of this subfamily of proteins to be shown to have a function in cell growth. Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide. Consistent with the cell specific defect in the roots of kjk mutants, KOJAK/AtCSDL3 is preferentially expressed in hair cells of the epidermis. The Kjk(-) phenotype and the pattern of KOJAK/AtCSLD3 expression suggest that this gene acts early in the process of root hair outgrowth. These results suggest that KOJAK/AtCSLD3 is involved in the biosynthesis of beta-glucan-containing polysaccharides that are required during root hair elongation.

    Grape Seed Extract
    Nutraceuticals as anti-angiogenic agents: hopes and reality.
    Angiogenesis, the formation of new blood vessels from preexisting vascular network is a driving force of organ development in ontogeny, is necessary for ovulation and hair growth, and is prerequisite for proper wound healing. It is also a critical mechanism of numerous diseases, the most important of which are cancer and atherosclerosis. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant compounds, often referred to as nutraceuticals are recently tested for the potential clinical applications. Among the most frequently studied are resveratrol, a polyphenol present in red-wine and grape-seed, epigallocatechin-3-gallate (EGCG) from green tea and curcumin from Curcuma longa. It is also possible that components of other plants, including the constituents of local food diet may find application for modulation of angiogenesis, provided that their effectiveness will be confirmed in controlled, scientifically validated trials.

    Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo.
    For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds of plant extracts concerning growth-promoting activity with respect to hair follicle cells. After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (100%); and that proanthocyanidins possess remarkable hair-cycle-converting activity from the telogen phase to the anagen phase in C3H mice in vivo test systems. The profile of the active fraction of the proanthocyanidins was elucidated by thiolytic degradation and tannase hydrolysis. We found that the constitutive monomers were epicatechin and catechin; and that the degree of polymerization was 3.5. We demonstrated the possibility of using the proanthocyanidins extracted from grape seeds as agents inducing hair growth.
     
  6. JayB

    JayB Experienced Member

    Joined:
    Dec 1, 2004
    Messages:
    691
    Likes Received:
    8
    Dislikes Received:
    0
    Sublime
    with a regimen like yours, if you dont have a full head of hair with no signs of balding...its kinda ridiculous
     

Share This Page