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L’oreal: Next Big Player In Hair Cloning

Discussion in 'New Research, Studies, and Technologies' started by RolfLeeBuckler, Mar 26, 2020 at 1:18 AM.

  1. RolfLeeBuckler

    RolfLeeBuckler Established Member My Regimen

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    Source: www.folliclethought.com

    Today, I’m happy to be sharing a “never seen online before” poster of a L’Oreal research project involving the creation of hair follicle organoids in a dish. This type of work is commonly referred to as “hair cloning” – the ability to create brand new hair follicles outside the body using various types of follicle cells and stem cells.

    For the past several years it’s been known that L’Oreal has embarked on a research collaborationwith the biopriting specialist company Poietis for the purpose of 3D-printing hair follicles.. Now, for the first time we are seeing the work that L’Oreal has been putting in on their end to develop a “hair follicle cultivation” model. And for those wondering, yes, the work below involves all human cells.



    D3D5F244-3CDE-4D55-9188-82A271126672.png


    The text on the poster is difficult to read unless you’ve enlarged the image by clicking on it. I’ll share the introduction of the poster here:

    “Mammalian hair follicle morphogenesis results of highly complex and coordinated interactions between epithelial and mesenchymal cells, which, when injected into mouse skin, conduct to hair follicle neo-genesis.
    Recently, several hair follicle organoids were reported:
    – in vitro 3D hair follicle germ structures from mouse embryonic cells were obtained and resulted in de novo hair follicles growth when injected (1).
    – Preliminary results showed that in vitro combinations of human outer root sheath keratinocytes and dermal papilla fibroblasts led to long rod organoid structures (2,3).
    – More surprisingly, hair shaft growths were produced in vitro from pluripotent stem cells derived from mouse embryonic cells (2).
    The challenge to produce such organoids from human adult hair follicle progenitor cells remains to be take up in the goal to pave the way of regenerative medicine. We developed new methods to amplify human hair follicle matrix cells and to produce neo dermal papilla spheroids. An original combination of both drives to the growth of hair organoids with K85 positive cells.”

    I believe the publishing of this poster may change the way people view “the race” to a hair cloning therapy over the next decade. It’s nice to have one of the largest companies in the world involved. We can be mostly sure there is still some work to be done in perfecting L’Oreal’s hair follicle culturing process, however, when it is ready, the idea of producing follicles with Poietis’ bioprinting is highly appealing. Without revealing any specific details at this time, L’Oreal’s Head of Advanced Research told me that the L’Oreal team will continue to put best efforts towards this project and hope to publish their work when ready.

    This poster has been previously shared at an American Hair Research Summit and a European Hair Research Society Meeting. Special thanks to Mickael Le Balch for sharing this work with the readers of Follicle Thought.
     
    Ollie, Ikkaku, Oueyy and 12 others like this.
  2. MeDK

    MeDK Established Member My Regimen

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    Not this site again.

    But nothing like a mouse study ! seems like we have seen those before. So we are still +10 years away from making this relevant to even thinking about market release.

    What is actually interesting with the whole "bio-printhing / 3D printing / 4D printing" it have many names, is that the process have been lower A LOT, so instead of our we talk about minute for printing a cubic centimetre.
     
  3. Joseph@FT

    Joseph@FT New Member

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    "But nothing like a mouse study !" - MeDK

    5th sentence of the article: "And for those wondering, yes, the work below involves all human cells." i.e. does not involve mice at all
     
    #3 Joseph@FT, Mar 26, 2020 at 10:16 AM
    Last edited: Mar 26, 2020 at 10:29 AM
    Marcaronii and pegasus2 like this.
  4. Derelict

    Derelict Senior Member My Regimen

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    Good news for those past the point of no return i guess, wish there was more coming out to help those who are not NW7 but it's still good news.
     
  5. disfiguredyoungman

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    I want to be excited but I kinda lost all hope.
     
  6. telogen

    telogen Established Member My Regimen

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  7. NoMoney

    NoMoney Established Member My Regimen

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  8. RolfLeeBuckler

    RolfLeeBuckler Established Member My Regimen

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  9. j4r0d

    j4r0d Member

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    This stuff should not be even mentioned... it might only be available for the next generation of balding men; ie 10years away if not more.
     
  10. MeDK

    MeDK Established Member My Regimen

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    ehm...

    Looks like a mouse study to me, just like others have used human cells in mice ... so... a mouse study
     
  11. MrV88

    MrV88 Senior Member My Regimen

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    Didn't knew that Tsuji has injected something in Humans...so? Just wondering when they're going to start trials and what their aim is... L'Oréal ain't small and has a lot of money, but France and Europe is pretty fucked up at the moment
     
  12. MeDK

    MeDK Established Member My Regimen

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    what are you talking about?

    Tsuji like all other preliminary studies have been done in mice
     
  13. MrV88

    MrV88 Senior Member My Regimen

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    That's what I'm talking about... The L'Oreal study ain't just a normal standard mice study.. it's more complicated and so on, but you have to try it on mice first, so no reason to panic because it's in mice like said before
     
  14. BaldAndBalder

    BaldAndBalder Established Member My Regimen

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    I'm sorry i just can't take L'oreal seriously, their whole business is built around selling sneak oil to middle age women.
     
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  15. Joseph@FT

    Joseph@FT New Member

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    Sure, I'll explain it to you.

    The first sentence of the introduction which talks about injecting into mouse skin is providing background context for their current research. It's alluding to studies which have been done in the past, not the actual study that this poster depicts.

    The 3rd sentence in which you highlighted mouse embryonic cells is also a preamble to their current research, that's why it has a little number "1" at the end of it. If you check the bottom of the poster under "References" and then the number "1" you can read about the mouse embryonic cells study done by another research group.

    The sentences you must be looking for are the last 2 sentences of the introduction. They go like this: "We developed new methods to amplify human hair follicle matrix cells and to produce neo dermal papilla spheroids. An original combination of both drives to the growth of hair organoids with K85 positive cells." Truly hope that helped. This gives me yet another chance to say "this study involves human cells only."
     
    RolfLeeBuckler likes this.
  16. Armando Jose

    Armando Jose Senior Member My Regimen

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    a 2015 video, .... any more recent?
     
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  17. norwood 11

    norwood 11 Experienced Member My Regimen

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    This bs has been around since 2017. Only thing L’Oréal is capable of doing is making my gal’s hair soft and perfume-y. Let it go, it isn’t happening.
     
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  18. Joxy

    Joxy Established Member

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    Mouse study yes, but with fully human stem cells. That is big advantage.
     
  19. Joseph@FT

    Joseph@FT New Member

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    No mice involved in this study whatsoever, just human cells in a petri dish. Hence no photos of hair growing on mice.

    My previous response explained quite a bit.
     
  20. Joxy

    Joxy Established Member

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    Neither scientific peer review article supporting their claims.
     

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