List Of All Available Treatments (help Appreciated)

[-Synergy-]

[QUOTE="-

Lemon - Contains hesperetin as its main flavonoid for inhibiting transforming growth factor beta (TGF-B)

what about drinking lemon juice everyday, or it have to be topical?
and which dose should it be?[/QUOTE]

The point of hesperetin is to help remove oxidative stress. Hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase is an enzyme that uses hesperidin and H2O to produce hesperetin. In lemons there is 18 mg of hesperidin.

This has a list of TGF-B inhibitors: https://selfhacked.com/blog/tgf/

This shows how much hesperidin was used orally to relieve oxidative stress: https://www.ncbi.nlm.nih.gov/m/pubmed/15683547/

https://www.google.com/amp/s/www.re...Mouse_Exposed_to_Partial_Body_g-Radiation/amp

Other resource: https://en.m.wikipedia.org/wiki/Hesperidin

I hope that answers your question you can also buy hesperidin in supplement form.

 

[-Synergy-]

So if animals were pretreated with hesperidin (100 and 200 mg per kg of body weight orally) and the average human weighs 150 pounds/68.0389 kilograms. You would need to consume roughly 10,200 mg of hesperidin lol or 566 lemons (18mg per 100g of lemon) if my math is right in a reasonable time period for a positive significant difference on oxidative stress. I mean a person could get squeezing now while there is still daylight or just go with topical. There would probably be a greater effect from localization. The head weighs 20 pounds/9.07185 kilograms on average so about 1,350 mg applied topically. That would mean the power of 75 lemons. Unless you went with 300g peppermint which contains 481 mg Hesperidin per 100g. Alternatively, you could probably dry out the lemon as a way to extract hesperidin, but using peppermint topically would probably be easier.

This is why I need to learn a thing or two about extraction in chemistry. It is no wonder why people feel their scalp cooling and breathing so much when they apply peppermint or menthol shampoo or oils. It is helping the scalp and follicles oxygen. However, the concentration of hesperidin could be better for more results if at the same time skin irritation could be avoided or kept a close eye on during use.

100 grams visually

 

[Armando Jose]

The point of hesperetin is to help remove oxidative stress. Hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase is an enzyme that uses hesperidin and H2O to produce hesperetin. In lemons there is 18 mg of hesperidin.

Interesting

https://read.qxmd.com/read/30872609...s-by-a-transient-endogenous-production-of-ros

The emerging variety of signalling roles for ROS in eukaryotic cells and tissues is currently a matter of intense research. Here we make use of ex vivo cultured single human hair follicles as an experimental model to demonstrate that a transient production of non-lethal endogenous ROS levels in these mini-organs promotes efficiently the entry into the growth phase (anagen). The stimulatory process implicates the specific activation of the hair follicle stem cell niche, encompassing the induction of stem cell differentiation markers (Ck15), overall cell proliferation and sustained growth of the tissue associated with expression of gen targets (Ccnd1) concomitant with the inhibition of Wnt signaling antagonists and repressors (Dkk1, Gsk3β) of Wnt signaling. As a whole, this observation indicates that, once activated, ROS signalling is an intrinsic mechanism regulating the hair follicle stem cell niche independently of any external signal.

 

[-Synergy-]

Awesome this is Reactive oxygen species?

https://en.m.wikipedia.org/wiki/Reactive_oxygen_species

Oh, yeah right here:
https://read.qxmd.com/read/27586523...ros-production-in-mammalian-cells-and-tissues

 

[BaldLion]

[QUOTE="-

I hope that answers your question you can also buy hesperidin in supplement form.[/QUOTE]

Yes, your answer have been very usefull,

i think you are right in many things

Do you think that inhibiting PGD2 could solve how many pourcent of the balding power? 5% 20% 40% 70% for a random male patern baldness? just to get an idea, thanks for your knowledge

 

[-Synergy-]

I think everyone's hair loss experience can be different. It seems like it begins slowly and mostly unnoticeable with the quality of the hair slipping and starting to appear frizzy (onset of very slight miniaturization like with age). As if in the beginning the cortex, cuticle, or keratin is sickened. This seems like the first stage when the frizz could be mistaken for dryness or split ends. Then at least for me, it gets worse with the addition of more oils being produced by the scalp. These oils are obviously from the sebaceous gland possibly coming into contact with inflammation and trying to soothe scalp inflammation that exists in the dermal layer of the skin, but we can't yet feel the inflammation in the early stages. I have read somewhere that a 3rd-degree burn is a burn that reaches the dermis. if this is true then the slightest inflammation can do a ton of harm to the dermal layer and hair follicle over the long haul. The damage of inflammation builds up as it harms the dermal layer, hair follicle, and arrector pili muscle causing more inflammation. This is probably when people start to notice aggressive hair loss that the rate of growth can't keep up with anymore. There will always be micro-inflammation, but with us, it gets out of control and causes permanent damage at the dermal layer we can't see. Why this inflammation starts could be from a combination of DHT and an autoimmune response. There is a study somewhere that shows 30% of those suffering from androgenetic alopecia tested positive for antinuclear antibodies (ANA). I wonder the degree of perceived scalp pain for that 30% though??? I ask this because I went to the doctor and had ANA tested during terrible scalp pain and it came back positive (previously had thick hair until inflammation and ANA positive). Now I could have something else besides androgenetic hair loss like lupus, or my MPH inflammation is registering like in the study I mention? What if we all are having an immune response only it can't be detected in everyone because it's weaker in some and stronger in others? Also, some people naturally have thicker hair or thinner hair so the autoimmune reaction could be very slight and still cause those with thinner hair to lose fast? In my opinion, inflammation is 30% of the problem, DHT is 40 - 50% and the lack of growth factors from inflammation and DHT is 20 - 30%. However, it would make sense for these numbers to be different for everyone especially when people report some treatments as a miracle and others report it as trash. Overall, it doesn't matter because inflammation definitely doesn't enhance cellular function. This post got way too long, but I was looking into Methylsulfonylmethane (MSM) and it seems to help inflammation and arthritis with a dose-response curve and well tolerated. I looked at the ingredients in Viviscal and L - Cysteine seems to be great for keratin formation. While shark cartilage has mucopolysaccharides and collagen to maybe help reduce oil production and dermatitis but has anyone ever heard of Foltene like in the study below?

MSM - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372953/
L - Cysteine - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017824/
Shark cartilage(mucopolysaccharides and collagen) - https://www.ncbi.nlm.nih.gov/pubmed/2978541 would have to find polydeox from some other source or just buy Folten maybe.