Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

[bekeero]

Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

/PRNewswire/ -- Kintor Pharmaceutical Limited (stock code 9939.HK, "Kintor Pharmaceutical" or the "Company"), a clinical-stage biotechnology company developing...

www.prnewswire.com

 

[Zon Ama]

Awesome, they are moving faster than expected

 

[Numerous_Bet_3027]

Amazing news especially for the younger folks. If it outperforms finasteride it will be a great product with almost no side effects. Probably won't do much in the regrowth department but Kintor sounds like the real deal. They are moving super fast, I just find it a bit strange that they compete with their own product (Pyrilutamide) but maybe the different mechanism from GT20029 is even better.

 

[Spanishboy97]

How is this action mechanism diferentent from their Pyralutamyde?

 

[Tom4362]

How is this action mechanism diferentent from their Pyralutamyde?

It destroys the receptor instead of binding to it to compete with the androgens (Pyrilutamide)

 

[trialAcc]

I'm pretty excited for this, but are the potential sides of this not going to be far greater then current topical AAs? Imagine this going systematic and degrading AR receptors in other tissues.

 

[clams]

Amazing news especially for the younger folks. If it outperforms finasteride it will be a great product with almost no side effects. Probably won't do much in the regrowth department but Kintor sounds like the real deal. They are moving super fast, I just find it a bit strange that they compete with their own product (Pyrilutamide) but maybe the different mechanism from GT20029 is even better.

I dont think it’s strange. This is cutting edge technology while Pyrilutamide is less so but is essentially guaranteed for success.

 

[orphanfunkhouser]

surprised this doesnt have that much hype around it, or does it? seems legit yet something like brotzu lotion gets 10x the hype as this lol

 

[Zon Ama]

Kintor seems to talk less than any other company in this field, they rather execute.

btw: anyone invested in Kintor? Their pipeline looks promising, the stock exploded since late 2020

 

[Numerous_Bet_3027]

Kintor seems to talk less than any other company in this field, they rather execute.

btw: anyone invested in Kintor? Their pipeline looks promising, the stock exploded since late 2020

I thought about it but it's hard to tell what drives the stock price. They have different products in the pipeline..

 

[trialAcc]

I thought about it but it's hard to tell what drives the stock price. They have different products in the pipeline..

It's their covid drug application right now.

 

[Pls_NW-1]

I'm pretty excited for this, but are the potential sides of this not going to be far greater then current topical AAs? Imagine this going systematic and degrading AR receptors in other tissues.

Someone already put some BroScience on it lol.

Due to it being a small molecule and having a bigger affinity and degrading properties, it attaches directly to the receptors, located in follicles and scalp, and because of that, there aren't many left-overs going further down the route. Other topical AA's would accumulate further into the body, as they get outcompeted by endogenous androgens to the AR and do not attach to direct AR's in follicles and scalp, but more-over to AR's less concentrated with androgens. We do know that hormones get synthesized in the follicle itself.

It sounds pretty logical, but it's purely speculation and not scientifically based.

 

[Tom4362]

surprised this doesnt have that much hype around it, or does it? seems legit yet something like brotzu lotion gets 10x the hype as this lol

Because it's only in phase I

 

[trialAcc]

Because it's only in phase I

Yup, if this shows promise/safety in a phase 2 study the hype around it will start to get pretty crazy. If the AR is responsible for keeping follicles dormant I wonder what type of growth reaction you could get in conjunction with wounding when the AR receptor no longer "exists".

 

[pegasus2]

Yup, if this shows promise/safety in a phase 2 study the hype around it will start to get pretty crazy. If the AR is responsible for keeping follicles dormant I wonder what type of growth reaction you could get in conjunction with wounding when the AR receptor no longer "exists".

The AR is not responsible for keeping them dormant. Castration after the onset of balding halts its progression but does not reverse it. The PRLR might be responsible for keeping stem cells dormant. It would be a possible explanation for why hair loss usually happens around age 40 when testosterone declines and prolactin increases, although DHT stays the same and I don't know about scalp dht/prl.

 

[NorwoodGuardian]

The AR is not responsible for keeping them dormant. Castration after the onset of balding halts its progression but does not reverse it. The PRLR might be responsible for keeping stem cells dormant. It would be a possible explanation for why hair loss usually happens around age 40 when testosterone declines and prolactin increases, although DHT stays the same and I don't know about scalp dht/prl.

Is it a consensus that hair follicles don't die but remain dormant in bald scalp?

 

[pegasus2]

Is it a consensus that hair follicles don't die but remain dormant in bald scalp?

Yes, but not forever or for everyone, but in most people for a very long time, decades even.

 

[Spanishboy97]

The AR is not responsible for keeping them dormant. Castration after the onset of balding halts its progression but does not reverse it. The PRLR might be responsible for keeping stem cells dormant. It would be a possible explanation for why hair loss usually happens around age 40 when testosterone declines and prolactin increases, although DHT stays the same and I don't know about scalp dht/prl.

I though that hair loss estabilishes usually in your 40s, although I know that is very variable

 

[soull]

Yes, but not forever or for everyone, but in most people for a very long time, decades even.

Hello Pegasus, I would like to know your opinion about this possible treatment in people with miniaturized or fuzzy hair. I have seen cases that with only dutasteride they have thickened part of their miniaturized hairs. Thanks.

 

[pegasus2]

Hello Pegasus, I would like to know your opinion about this possible treatment in people with miniaturized or fuzzy hair. I have seen cases that with only dutasteride they have thickened part of their miniaturized hairs. Thanks.

It could thicken existing hairs if they haven't lost more than half their DP cells. Otherwise, just like dutasteride it has to be combined with minoxidil and wounding to make smaller vellus hairs grow.