Doctor,
.........on my topical idea. I was looking at compounds that inhibited IGF-beta 1, protien kinease C, and TNF-one.
Apple B2 proanthocyandin inhibits PKC. By the way, apple cider vinegar smells when you put it on, but your scalp absorbs it. You cant smell it later on.
Barley extract has been shown to grow hair on mice at a pubmed link Ive posted a few various places. It worked in vitro on epilitheal cells. The scientists checked and found that TGF beta 1 was what the barley B-3 proanthocyandins were suppressing. It worked in mice to grow hair. Thats in vivo. 140 percent was the increased growth if I remember correctly.
I thought topical grape seed extract counteracted TNF alpha. I might have to recheck...............here is one source for TNF alpha here:
TNF-a down regulation- Curcumin, Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, Fish Oil, Borage Oil, Perilla Oil, and Topical Perilla leaf extract
Thats from male pattern baldness-research.org. I'd choose topical borage oil or topical curcumin or topical ginko biloba (a weak alpha five inhibitor) rather than topical green tea.
Green tea inhibits angiogeneisis. Thats why its a good cancer fighting compound. But you WANT angiogenesis with hair.
Riboflavin is a alpha five inhibitor also that would be easy to make.
I remember reading a recipe by Waseda on preparing topical grape seed proanthocyanidins and it was to get water, alcohol, and grape seed extract and boil. I dont think the oligomers would degenerate at 120-130 degrees.
Doctor,
If a man could make a topical that inhibited the three negative growth factors, perhaps with a tad of topical dht inhibition to be used before the shower/during the shower, with a little prox-n at night, he'd probably keep his hair for ages. Or at least unitl cloning comes out (Aderans is now recruiting for phase one tests here in America and phase two is underway in England as we speak-------I really expect this in less than ten years now, and possibly five somewhere on the earth).
I know you dont want to screw with your internal hormonal profile, and I dont disagree with that. Even though Ive never been bothered by finasteride, I'd rather handle this topically if I could.
The old beer and eggs shampoo rememdy thats been around for hundreds of years perhaps wasn't such a bad idea. I had found one website that had a recipe for this that was simple.........boil beer until it loses about a quarter of its volume (most of the water and alcohol) and mix it with any old cheapie shampoo. Suds up and leave in for a few minutes. The barley and hops proanthocyanidns should penetrate. Apple cider vinegar, grape pulp (native american indians) barley have all been used for ages for hair. We didnt stop using this stuff unitl scientists told us it was stupid and testosterone caused baldness back early last century. Maybe we should have trusted Grandma and not listened to them for a while. I would STRONGLY imagine that apple cider vinegar, barley malt, and grape seed pulp applied to the head with aloe vera juice and an anti-inflammatory essential oil like thyme or rosemary would have outperformed minoxidil over a long period of time because they counteract alot more of the bad stuff happening in baldness than minoxidil does.
Ive spoken half jokingly about the barley malt and beta sitosterol content in Bourbon and wondered aloud if Jack Daniels to the head could slow baldness a great deal. Ive tested (successfully to my own curiousity) whether the beta sis in pine oil could slow body hair growth, thus proving the beta sis therein really had a anti-androgenic effect (it did). I suspended that little experiment because Im satisfied with the result. Im currently putting latanaprost on one forearm and have started putting a little bourbon on one cheek. I'd like to see that if in a few weeks the untreated cheek grows beard stubble faster after a shave at a few days (thus showing me that there is enough beta sis in boubon to inhibit androgenic binding there). Im going to try to apply twice a day.
Thats about all the natural substances I can really think of that might help with hair. There is a particular melon native to france that has a high amount of superoxide dismutase naturally. Ive done a little pubmed research on antigens that get suppressed by blueberries. It does ALOT. Blueberries are in alot of folk remedies for hair. The anthocyandins therein might be the most powerful anti-oxidants known to man. Blueberries, pomegranates, and cranberries are considered "superfoods". All three help with BPH. There are proanthocyandins in cranberries.
Doctor, I feel we might have "cures" for baldness in some plants, but just dont know it yet. However, Im still just hoping for cloning so I can forget about this sh*t once and for all to be honest.
If you ever try a topical....................I'd still suggest prox-N from LifeExtension.org. Proctor is a smart guy and baldness is all he studies. I think his product is the best non-hormonal treatment for this stuff going personally. Dutasteride is probably the best overall, but even I didn't feel like myself on that.
