I know that some people swear by Nizoral and all but after all, it's just a shampoo. so use it as you would with a normal one. If I understood correctly, you were asking if Nizoral would be better absorbed if/when the pores were open? mm..your guess is as good as mine! but people do use it during the hot shower so it wouldn't really do any harm I guess. Do you use anything else for your hair loss by the way?