Is my skin gonna turn to sh*t?

[buzzmenot]

water retention, drink diuretics or cut the dose

 

[UK1]

As with most treatments, there are no guarantees, everyone is different, just get involved and work it out as and when it happens, I have been on the foam for 6 weeks now and have experienced nothing like this.. yet..

 

[UK1]

The deal is that you're an idiot, just persist with your treatment or be a bald one.

 

[wookster]

I don't know if this would cause wrinkly skin or not...

http://www.medscape.com/viewarticle/470297_5

Collagen Synthesis
Two groups have studied the effect of minoxidil on collagen synthesis. Murad and Pinnell[48] showed that minoxidil suppressed activity of the enzyme lysyl hydroxylase in human skin fibroblast cultures at concentrations down to 25 µmol L,-1 leading to production of a collagen deficient in hydroxylysine.[49] This appeared to be specific for lysyl hydroxylase as the activity of prolyl hydroxylase, which shares the same substrates and cofactors as lysyl hydroxylase, was unaffected. Minoxidil (0.5 mmol L-1) also suppressed collagen synthesis by rat vibrissae dermal papilla cells, both in monolayer cultures and in cells grown in collagen gels.[50] The concentrations of minoxidil used in these studies were quite high and the relevance of the results to hair growth is unknown.

 

[roki]

so it could have a bad effect...

 

[ShedMaster]

I don't know if this would cause wrinkly skin or not...

http://www.medscape.com/viewarticle/470297_5

Collagen Synthesis
Two groups have studied the effect of minoxidil on collagen synthesis. Murad and Pinnell[48] showed that minoxidil suppressed activity of the enzyme lysyl hydroxylase in human skin fibroblast cultures at concentrations down to 25 µmol L,-1 leading to production of a collagen deficient in hydroxylysine.[49] This appeared to be specific for lysyl hydroxylase as the activity of prolyl hydroxylase, which shares the same substrates and cofactors as lysyl hydroxylase, was unaffected. Minoxidil (0.5 mmol L-1) also suppressed collagen synthesis by rat vibrissae dermal papilla cells, both in monolayer cultures and in cells grown in collagen gels.[50] The concentrations of minoxidil used in these studies were quite high and the relevance of the results to hair growth is unknown.

what does this study mean? can anyone translate? Brian?

 

[Rob_x_22]

i have to admit since starting rogaine my face looks a lot worse 2 chins and bags under eyes and i'm really fit work out every day ...guess i need to drink more h2o

 

[Guest]

Someone on the other board(hairlosshelp.com) referred to rogaine as poison. I thought it was safe to use, what is the deal????

stop trolling

 

[hellohello]

been using rogaine for two years and out of all my mates i have probably the best skin

 

[wookster]

http://www.medscape.com/medline/abstract/15908192

Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: implications for collagen cross-linking and treatment of fibrosis.
Medscape Newsletters

Matrix Biol. 2005; 24(4):261-70 (ISSN: 0945-053X)
Zuurmond AM; van der Slot-Verhoeven AJ; van Dura EA; De Groot J; Bank RA
TNO Quality of Life, Biomedical Research, Department of Tissue Repair, P.O. Box 2215, 2301 CE Leiden, The Netherlands.

Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl hydroxylase activity minoxidil has been postulated to possess anti-fibrotic properties by limiting the hydroxylysine supply for hydroxyallysine cross-linking. However, to interfere with hydroxyallysine cross-linking specifically lysyl hydroxylation of the collagen telopeptide should be inhibited, a reaction predominantly catalysed by lysyl hydroxylase (LH) 2b. In this study, we demonstrate that minoxidil treatment of cultured fibroblasts reduces LH1>>LH2b>LH3 mRNA levels dose-and time-dependently, but has essentially no effect on the total number of pyridinoline cross-links in the collagen matrix. Still the collagen produced in the presence of minoxidil displays some remarkable features: hydroxylation of triple helical lysine residues is reduced to 50% and lysylpyridinoline cross-linking is increased at the expense of hydroxylysylpyridinoline cross-linking. These observations can be explained by our finding that LH1 mRNA levels are the most sensitive to minoxidil treatment, corroborating that LH1 has a preference for triple helical lysine residues as substrate. In addition, the non-proportional increase in cross-links (20-fold) with respect to the decrease in lysyl hydroxylation state of the triple helix (2-fold) even suggests that LH1 preferentially hydroxylates triple helical lysine residues at the cross-link positions. We conclude that minoxidil is unlikely to serve as an anti-fibroticum, but confers features to the collagen matrix, which provide insight into the substrate specificity of LH1.

This is a very good clue it seems. It appears that lysyl residues might build up around or in the follicles, impeding growth. There is a strong link between heart disease and baldness. Women generally don't suffer from heart disease or baldness until after menopause, then that is also when their estrogen levels drop and testosterone levels rise, precipitating the 5AR - DHT transformation.

So it appears that fibrosis and collagen crosslinks are forming around or in the hair follicle structures and that would be a cause of hair follicle miniaturization and the ...contact inhibition? along with higher scalp blood pressures...

 

[Pondle]

As long as you aren't applying minoxidil all over your face, surely you won't have a problem with wrinkles!

 

[dietcola]

NO HAIR LOSS TREATMENT IS VOID OF SIDE EFFECTS

i can't believe how many people want to treat hair loss but are so scared of taking medications or using treatments for fear of side effects.

go ahead and be scared of the side effects that you were unlikely to experience anyways.

do you cry when you drive your car for fear of an accident?