is it ok to use spironolactone 5 % once a day?

[Guest]

or do you have to take it twice? what about the 2 % is it the same for it?

 

[CCS]

better than nothing, but you're follicles will be under attack the other half of the day. I don't know exactly how many hours.

 

[chino20]

But how long do androgen receptors stay blocked for? Maybe they stay blocked after the spironolactone has worn off.

Does spironolactone wear off at the same speed when applied topically as it would do internally?

 

[ANDREW_J_I]

college, how well does spironolactone actually work in terms of dht % blocked??

 

[Bryan]

But how long do androgen receptors stay blocked for? Maybe they stay blocked after the spironolactone has worn off.

Does spironolactone wear off at the same speed when applied topically as it would do internally?

I don't think anybody really knows for sure the answers to either of those questions. But this is where I traditionally step in and point out that in a couple of the well-known topical spironolactone studies with hamsters (Noto et al, Weissmann et al), the spironolactone was applied only once a day, and not at all on weekends in one of them (Noto). I maintain that it's not obvious why humans would respond any differently in that regard than hamsters.

Bryan

"Topical Canrenoic Acid", Noto et al, Int J Dermatol, November 1991, Vol. 30, No. 11.

"Antiandrogenic Effects of Topically Applied Spironolactone on the Hamster Flank Organ", Weissmann et al, Arch Dermatol 1985; 121:57-62.

 

[ANDREW_J_I]

^do u know how much dht spironolactone cuts out Bryan? approximately.
and whether its effective, because it isnt approved.

 

[Bryan]

^do u know how much dht spironolactone cuts out Bryan? approximately.

Can't say for sure, but in the two studies I posted above, topical spironolactone had about HALF the effect (roughly) of castration. I'm sure it's not even THAT strong, in humans. Nevertheless, there are at least a couple of human studies showing that it's helpful for hairloss.

Bryan

 

[ANDREW_J_I]

^thanks bryan, also, you would have to apply it perfectly to gain those results day in day out.

 

[Goingat20]

i think for spironolactone to be a effective it would have to be applied twice daily.

 

[chino20]

Well my experience with topical spironolactone is this: (Bear in mind i also used finpecia)

I used it twice a day from febuary until august, during that period of time i did see a few hairs come back where i was applying it (hairline and temples). I had to go on holiday for a week, and while there I didn't apply it at all, but continued with the finpecia. When I came back I noticed that several more hairs had come through on my left temple. Since then I have used it once per day, some days not at all, and have not lost any of those i saw come through.

I think spironolactone is not a topical you have to stick 'religiously' to, but it is helpful whenever you put it on, so probably the more the better. Although, I also think it MAY block pores which might explain why I saw those hairs come through after my hiatus from spironolactone, although I'm not sure what effect blocking pores has on hair growth.

Also, sometimes if i apply it in the morning, and at night rub an area I apply it to, I can smell the smell of the cream on my fingers... Not sure what that means.

 

[Dave001]

Given spironolactone's lipophilic character and molecular weight, its concentration probably builds up in the skin with repeated applications. It could degrade fast, I suppose, but it is fairly stable ex vivo.

It was applied once/day in the acute phase of that autoradiographic study in humans, IIRC. DHT-binding was reduced substantially in the tissue specimens.

Topical drug delivery is generally a "timed-release" phenomenon. This is especially true of lipophillic steroids and steroid-like molecules.